Building Blocks

<p>Versatile small molecule scaffold</p>

<p>2,4-Dichloroquinoline-3-carbonitrile is a nitrosourea compound that inhibits cancer cells. It is activated by the addition of a reducing agent such as triethyl orthoformate and then reacts with an amine to form the corresponding N,N'-dichloroquinoline. The product of this reaction inhibits cancer cells by binding to DNA and inhibiting RNA synthesis. 2,4-Dichloroquinoline-3-carbonitrile has been shown to be effective against leukemia cells in vitro.</p>

<p>Versatile small molecule scaffold</p>

<p>6-Hydrazinylpyridine-3-carboxamide is a coligand with high affinity for technetium, which is used in analytical chemistry. The compound has been shown to bind to the transcription-polymerase chain reaction (PCR) and monoclonal antibody binding sites of the human immunodeficiency virus type 1 (HIV-1). 6-Hydrazinylpyridine-3-carboxamide has also been shown to be an effective inhibitor of protein synthesis in animal cells and to inhibit tumor cell growth. Clinical trials have demonstrated that this compound can be used as an aneurysm sealant and as a cancer treatment.</p>

<p>3-Oxo-3-(3-thienyl)propanenitrile is a metabolite of 3-oxothiopropanal. It is an analog of prostaglandin, which has been shown to have antiinflammatory properties. 3-Oxo-3-(3-thienyl)propanenitrile has been used in the treatment of adjuvant arthritis and was found to inhibit the production of prostaglandins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Ethylamino)benzaldehyde (2-EABA) is a reactive, radiation-sensitive compound that can be used as a diagnostic agent. 2-EABA is the precursor of styryl dyes and coumarin derivatives. 2-EABA reacts with chloride to form an amide in the presence of hydroxyl groups. The amide reacts with aromatic hydrocarbons to produce cationic polymers. The reactive functional group of 2-EABA is an aldehyde group, which reacts with basic dyes to form diamines and diamides. In addition, it has been shown that 2-EABA can be used to detect chloride ions in water samples, owing to its high solubility in water.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Phenoxycyclobutan-1-one is a chemical compound that belongs to the group of sulfoxides. It is an intermediate in the synthesis of other compounds, such as methyl esters and sulfones. 3-Phenoxycyclobutan-1-one can be synthesized by coupling with phenol and cyclohexanone in the presence of a base. 3-Phenoxycyclobutan-1-one is also a precursor for the synthesis of other compounds, such as dyes and pharmaceuticals. The conversion to 3-phenoxycyclobutanones requires pyrolysis at temperatures greater than 300°C.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methoxy-2,5-furandione is a reactive functional group that belongs to the group of β-carboline alkaloids. It is used as a crosslinker in polyvinyl and iontophoresis applications, as well as a cross-linking agent for coatings or natural compounds. 3-Methoxy-2,5-furandione reacts with benzyl groups to form crosslinked products that are stable in acidic environments. This product is also used as an intermediate for the synthesis of tetronic acid (a coating) or reaction products.</p>

<p>2-Chloro-6-(2-methylpropyl)pyridine-3-carbonitrile is a naphthyridine that has been correlated to the ionization of the molecule. The substituent on the nitrogen atom is not ionized, while the nitrogens on the ring are. This difference in ionization constants allows 2CMP to be used as a research tool for studying nucleic acids and proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-[5-Methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]ethan-1-one is a nicotinic compound that has been synthesized. It is a thiosemicarbazide derivative that reacts with azide compounds to form pyridine derivatives. The reaction with halides and amines leads to the formation of pyridines and thiosemicarbazones, respectively. Phenylcarbamate can be formed by reacting phenols with this compound. Elemental analysis shows that 1-[5-Methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-- yl]ethan-1-- one is composed of hydrogen (H), carbon (C), nitrogen (N), and oxygen (O).</p>

<p>Versatile small molecule scaffold</p>

<p>5-tert-Butyl-1H-indole-2-carboxylic acid is an acidic, carboxylic acid that is synthesized from indole and benzene. It has a moiety of substituents on the phenyl ring. 5-tert-Butyl-1H-indole-2-carboxylic acid is synthesised by reacting indole with benzene in the presence of trifluoroacetic acid and sodium hydroxide. This reaction yields 5-(benzoyloxy)indole and 5-(benzoyloxy)indole carboxylic acid. The carboxylic acid can be obtained as a white solid that is soluble in water, ethanol, and ether. The brain membranes contain high concentrations of this compound, which can be used to study its function as a neurotransmitter or neuromodulator.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoic acid (EMSB) is a nitrogen and sulfonamide compound that belongs to the class of piperazine derivatives. It binds to the 50S ribosomal subunit in bacteria, preventing mRNA translation and inhibiting bacterial growth. EMSB has been shown to inhibit the growth of Mycobacterium tuberculosis and Staphylococcus aureus. EMSB also inhibits aminoacyl-tRNA binding and protein synthesis in bacteria. This drug has been shown to be active against methicillin resistant Staphylococcus aureus (MRSA) isolates in laboratory tests.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Bromophenyl)tetrahydrofuran is a heterocyclic compound that is a chiral molecule. The racemic mixture of 2-(4-bromophenyl)tetrahydrofuran exists as two enantiomers, which can be separated in a chiral column. This molecule has been studied for its mechanistic effects on focusing. A systematic study was performed to investigate the mechanism of 2-(4-bromophenyl)tetrahydrofuran and its analogs. The chemical structure of this molecule is similar to that of natural products such as lactones and enantioselectivity agents, which may be useful for the synthesis of new drugs.</p>