Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>YM-298198 hydrochloride is a novel allosteric modulator of metabotropic glutamate receptors, which are involved in the modulation of neuronal activity. It has been shown to inhibit the neurotransmitter release of dopamine and glutamate. YM-298198 hydrochloride has also been shown to have neuroprotective effects in models of Parkinson's disease and Alzheimer's disease. It inhibits the release of glutamate and dopamine, which may be due to its ability to bind to the metabotropic glutamate receptor by an allosteric mechanism.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 4-(2-phenylethynyl)benzoate is a quinoid compound. It has been studied for its electron, magnetic and crystallographic properties. The cyclic voltammetry of methyl 4-(2-phenylethynyl)benzoate shows a 1:1 square-wave voltammetry with a peak potential of 0.84 V vs. Ag/AgCl. The electronic structure of the molecule has been studied by means of resonance and one-electron reduction methods, which have shown that the molecule can be described as an analogous to benzene in terms of both spectra and nmr spectra.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4,6-Diamino-2-bromonicotinonitrile (DAB) is a chemical compound that inhibits phosphodiesterase enzymes. It has been shown to inhibit cyclic nucleotide phosphodiesterases, including PDE5, which is found in tissues and bronchial passages. DAB also inhibits the activity of phosphodiesterases in cells. The inhibition is reversible and uses hydrogenated fatty acids as substrates. This compound has been used as a cross-linking agent to induce antigenicity in proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Carbamoylamino)-4-methylpentanoic acid is an enzyme that catalyzes the hydrolysis of l-amino acids. It has a broad substrate specificity and is able to hydrolyze branched-chain and n-substituted l-amino acids, as well as D-amino acids. The active site of this enzyme includes a zinc ion coordinated by four amino acid residues, which are important for the stereoselective catalysis of these reactions. This enzyme also displays stereoselectivity in its reactions with L-amino acids over D-amino acids. The crystal structure of 2-(carbamoylamino)-4-methylpentanoic acid reveals that it belongs to the family of dipeptidases, whose members have a beta barrel fold common to many enzymes in this class.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Trichloroethanimidamide hydrochloride is a metal hydroxide with herbicidal activity. It is used as an intermediate for the production of herbicides and fungicides. The chemical composition of trichloroethanimidamide hydrochloride includes ammonium chloride, sodium chloride, potassium chloride, magnesium chloride, calcium chloride and iron chloride. This reagent can be used to isolate amines from other organic compounds. Trichloroethanimidamide hydrochloride has a boiling point of 161°C, which makes it useful as a solvent in organic synthesis reactions. Trichloroethanimidamide hydrochloride also reacts with toluenesulfonate to form an alkali metal salt, which can be isolated by vacuum distillation.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methylamino-3-nitrobenzaldehyde is a luminescent compound that can be used in the detection of oxidative metabolites. It is a mediator oxidation product of 4-methylaminobenzaldehyde and has been shown to be aerobic and phosphotungstic. This compound is recycled and does not interfere with other analytical methods. It can also be immobilized on a surface, such as silica gel or magnesium oxide, or immobilized in an acidic environment. The phosphotungstic acid used for this immobilization process is a biomimetic metal ion complex that has been modified to react with the triazole derivative.</p>

<p>Racemic 2-aminocycloheptanol is an organic compound with a molecular formula of C7H14Cl2NO and a molecular weight of 206.24 g/mol. It is classified as a substituted cycloheptane and has the IUPAC name rac-(1R,2R)-2-aminocycloheptan-1-ol. Racemic 2-aminocycloheptanol can be synthesized by the substitution of chlorine atoms for hydrogen atoms on the benzyl group in benzoic acid. This reaction requires catalytic amounts of sodium hydroxide to hydrolyze the benzoic acid, forming sodium chloride and racemic 2-aminocycloheptanol. Racemic 2-aminocycloheptanol is used in the synthesis of antidepressants such as amitriptyline and nortriptyline. These drugs are believed to have their therapeutic effects through inhibition of norepinephrine reupt</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2-[(1S)-1-Hydroxyethyl]-1,4-dihydroquinazolin-4-one is a quinazoline type compound that has been found to be an inhibitor of the type II fatty acid synthase (FAS II). The FAS II enzyme catalyzes the production of fatty acids and their derivatives by converting acetyl-CoA into malonyl CoA. The inhibition of FAS II leads to a decrease in the production of lipids, which are important components of bacterial cell membranes. This compound also inhibits the growth of fungi such as Monascus purpureus, Fusarium sporotrichioides, and Fusarium avenaceum at high concentrations. 2-[(1S)-1-Hydroxyethyl]-1,4-dihydroquinazolin-4-one was found to inhibit the growth of these fungi by binding to their elongation factor 1 alpha (EF-1α) and preventing</p>

<p>N-(3-Thienyl)acetamide is an aromatic aldehyde that is used in the synthesis of carbamates. It has been shown to be brominated, acetylated, and aminated. N-(3-Thienyl)acetamide can undergo dehydrogenation and heterocyclic amine formation during cooking. It also has electrophilic properties, which allow it to react with nucleophiles such as amines or thiols to form diazonium salts. This compound is a substrate for transamination and dihydropyridines.</p>

<p>8-Nitroquinolin-5-amine is a quinoline derivative that undergoes electrophilic substitution reactions with nucleophiles. This drug reacts with hydrogen chloride to give the corresponding 8-nitroquinolinium chloride. Reaction of this compound with imines gives the corresponding imine derivatives. Reaction of this compound with chlorides gives the corresponding 8-nitroquinolinium salts. The reactivity of this compound is similar to that of quinones, but it does not have a conjugated system and is not redox active.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Aminoquinolin-4-ol is a reactive nitrogen molecule that can be transformed into quinoline derivatives by reaction with methylene, amines, and primary amines. 2-Aminoquinolin-4-ol can also react with paraformaldehyde to form pyrimido compounds. These reactions are thermally induced. 2-Aminoquinolin-4-ol is nucleophilic and undergoes conjugation with aminoquinolines.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Benzyl-1,3-oxazolidin-2-one is a nonsteroidal antiinflammatory drug that acts as an analgesic and antipyretic. It inhibits the enzyme cyclooxygenase to reduce prostaglandin synthesis. 5-Benzyl-1,3-oxazolidin-2-one is a prodrug that is metabolized to its active form by hydrolysis of the ester linkage. The hydrolysis of this bond requires the presence of acid such as carbonic acid or trifluoromethyl acid. This drug also has antiinflammatory properties and has been shown to be effective in the treatment of muscle pain.<br>5-Benzyl-1,3-oxazolidin-2-one binds to phenoxy and aralkyl groups in proteins, which may account for its analgesic effects.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 5-aminosalicylate is a molecule that belongs to the class of nonsteroidal anti-inflammatory drugs. It is used for the treatment of bowel diseases and has been shown to inhibit inflammation in neurodegenerative diseases. Methyl 5-aminosalicylate can be converted from salicylic acid by aminopropionase, which converts choline into methylmalonyl CoA. The molecule is cytotoxic and has been shown to activate microglial cells in vitro. Methyl 5-aminosalicylate is also a dietary carbon source for some organisms.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tetrahydro-1-benzofuran is a heterocyclic compound with the chemical formula C4H6O. It is a furan derivative, and is classified as an alkylene. Tetrahydro-1-benzofuran has been shown to have anti-amnesic properties in animal studies for Alzheimer's disease. It also has been found to be useful as a reagent for organic synthesis. Tetrahydro-1-benzofuran can be used as a starting material for the synthesis of other heterocyclic compounds such as pyrrole and furanosesquiterpenes.</p>

<p>Versatile small molecule scaffold</p>