Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Ethyl 2-sulfamoylacetate is a carbonyl that is an inhibitor of the enzyme urea cycle. It can be used in the treatment of hyperammonemia, which is a condition where there is an excess level of ammonia in the body. This compound contains one sulfur atom and two nitrogen atoms, which are found in the formulae C5H7NSO2. Ethyl 2-sulfamoylacetate also has a heterocyclic ring with six carbon atoms and one oxygen atom. The substituents on this molecule are methylene, phenylene, and isothiazole.</p>

<p>Versatile small molecule scaffold</p>

<p>4,4-Dimethyl-1,2-thiazetidine-1,1,3-trione is a quaternary salt that can be isolated as a white powder. It has high molecular weight and is soluble in solvents such as benzene. 4,4-Dimethyl-1,2-thiazetidine-1,1,3-trione can be polymerized to form polymers and has an anionic charge at pH 7. The ring opening polymerization of this compound forms polymers with pyridine units. The ring opening polymerization of 4,4-dimethyl-1,2-thiazetidine 1,1,3-trione produces polymers with quaternary ammonium groups. These polymers are soluble in water and are stable to heat and light. 4,4 -dimethyl - 1,2 - thiazetidine 1 , 1 , 3 - trione has a molecular weight of 216.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

2,4-Dinitrophenylhydrazine Hydrochloride is a reagent used for labeling biomolecules in HPLC. The reaction time is dependent on the specific molecule and the concentration of reactants. 2,4-Dinitrophenylhydrazine Hydrochloride reacts with carbohydrates and other large molecules to form a hydrazone link. This link can be cleaved by heat or acid to release the labeled molecule. It is also used for labeling oligonucleotides, amino acids, and other small molecules that are not amenable for enzymatic reactions. This reagent has been shown to be useful in determining the molecular weights of anions such as chloride or crystallography. The red shift observed during this reaction is due to the interaction energies between water molecules and chloride ions or dimethylformamide molecules.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Diethyl 1H-pyrrole-2,4-dicarboxylate is a reactive and nucleophilic substituent that is used in organic synthesis. It has been shown to undergo substitution reactions with various functional groups, such as alcohols and amines. This compound can also be conjugated with other molecules, such as amino acids. Diethyl 1H-pyrrole-2,4-dicarboxylate is synthesized from pyrrole and diethyl malonate. It has been shown to have optimal activity against caco-2 cells when substituted for the 2,4-dimethoxybenzaldehyde component of the substrate.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Methyl 3,5-dichlorobenzeneacetate is a chemical compound that is used as a reagent for organic synthesis. It is also known as 1,3-dichloro-5-methylbenzeneacetic acid methyl ester and has the chemical formula CHClO. Methyl 3,5-dichlorobenzeneacetate can be prepared by reacting copper with nitrobenzene in the presence of an esterifying agent such as pyridine or acetic anhydride. This chemical has been shown to be useful as a catalyst for biomolecular reactions involving nitrogen sources. Methyl 3,5-dichlorobenzeneacetate can also be used as a nitrogen source in imidazolinones.

Versatile small molecule scaffold

<p>2-(Thiophen-2-yl)-1H-indole is a reagent that can be used in the screening of potential anticancer drugs. The compound has been shown to inhibit the growth of cultured human cancer cells by inhibiting the synthesis of DNA. This inhibition is due to its ability to interact with hydrogen bonds and hydrophobic interactions, which are key players in biological activity. 2-(Thiophen-2-yl)-1H-indole is potent against tumor cells and has been shown to have antiangiogenic effects on endothelial cells. This compound also inhibits transcription, leading to an increased number of transcripts.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Dibromo-1,3,4-thiadiazole is a heterocyclic compound. It has been shown that dibromo-1,3,4-thiadiazole can be synthesized by cross-coupling reactions of 2,5-dibromothiophene with pyridine-3-carboxylic acid and 1,2,4-triazole. The crystal x-ray diffraction data for this compound shows that it is a square planar molecule with a potential for a cyclic transition. The molecular formula for dibromo-1,3,4-thiadiazole is C8H6Br2N2S. Dibromo-1,3,4-thiadiazole has been used as a substrate in voltammetry experiments to study the rate of electron transfer between an electrode and the molecule. This process can be followed by observing the change</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-1-(furan-2-yl)ethan-1-one is a selenium compound that has been shown to have anti-inflammatory properties. This drug binds to the reactive oxygen species produced by the inflammation and prevents them from damaging cells. 2-Chloro-1-(furan-2-yl)ethan-1-one also has an effect on metabolic disorders, such as diabetes mellitus, where it inhibits the synthesis of amines that can lead to ketosis. It is also used to treat hepatitis, which may be due to its ability to inhibit the growth of bacteria. This drug has been shown to have antimicrobial activity against Mycobacterium avium and other infectious diseases.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-4-phenylbutan-2-one is an efficient method for the synthesis of secretory phospholipase A2 (sPLA2) inhibitors. This compound has been shown to inhibit a number of sPLA2 enzymes in vitro and in vivo, including those from human neutrophils, rat peritoneal macrophages, and rat pancreatic acinar cells. 3-Bromo-4-phenylbutan-2-one is hydrolyzed by a number of reagents, including acids and bases. It can also be used as a starting material for the synthesis of potent sPLA2 inhibitors with nonpancreatic activity.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>THP-1 cells were transfected with pcDNA3.1 plasmid encoding wnt/β-catenin pathway reporter and co-cultured with a mouse neural stem cell line, Cerebellar Granule Cell Line (CGC). The THP-1 cells were stimulated with 1-(pyridin-4-yl)-N-(thiophen-2-ylmethyl)methanamine (PTM), a Wnt ligand that is known to induce follicle development in the ovary, and then treated with the proteasome inhibitor MG132. The data showed that PTM induced ectopic expression of β-catenin in CGCs. This suggests that PTM may be a useful therapeutic tool for the treatment of follicle development disorders in humans due to its ability to induce β-catenin expression.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold