Building Blocks

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>1-(3-Nitrophenyl)-1H-pyrazole is a small molecule inhibitor of p38 kinase. It can be used to treat arthritis and other diseases that are caused by the overactivation of p38 kinase. 1-(3-Nitrophenyl)-1H-pyrazole also has the potential to be used as a combinatorial library for the discovery of new inhibitors for protein kinases.</p>

<p>3-isopropylpyrazin-2-ol is a volatile and catalytic compound that is used in the synthesis of methylated flavonols such as quercetin. It is a hydroxypyrazine that can be synthesized from the amino acid isobutylamine. 3-isopropylpyrazin-2-ol has been shown to inhibit o-methyltransferases and flavonol quercetin biosynthesis in tissues, and can be used for the production of other derivatives. This compound has also been shown to inhibit e coli growth, which may be due to its ability to inhibit enzymes involved in bacterial DNA replication.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Methyl cyclohex-2-enecarboxylate (MCHC) is a volatile compound that is found in actinomycetes and has been identified as the second major product of phenolic metabolism. MCHC is produced by the addition of an enolizable acetyl group to 2-cyclohexene-1-carboxylic acid. It can also be synthesized by the oxidation of cyclohexenyl alcohol, which is one of its main precursors. MCHC is a short-chain volatile compound that can exist as cis or trans isomers and has a boiling point of 136°C. The biosynthesis of MCHC occurs through a series of reactions that are difficult to identify because they have not yet been fully elucidated.<br>MCHC has been shown to cause cancer in animals, but it does not exhibit carcinogenic properties in humans because it does not bind well to DNA. The aromatic hydrocarbon content</p>

1-Benzyl-2-(bromomethyl)aziridine is a nucleophile that can be used as an intermediate in the synthesis of epoxides. It is used as a reactant in the formation of chiral epoxides, which are important for pharmaceuticals and agrochemicals. The addition of aziridines to activated esters provides the corresponding carboxylic acid. The reaction proceeds stereoselectively with 1-benzyl-2-(bromomethyl)aziridine, but not with other diamino compounds such as 1-benzyl-2-(chloromethyl)aziridine or 2-(bromomethyl)azetidine. Bromine is used to activate the carboxylic acid, which leads to a more reactive intermediate than other nonactivated forms.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>3,5-Dichlorophthalic acid is a divalent organic acid that is used as an intermediate in the production of other chemicals. 3,5-Dichlorophthalic acid is used as a regulator of plant growth and development. It can also be used to make different n-substituted compounds, such as naphthalene, phthalic anhydride, and 2,6-dichloro-pyridine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

4-Bromo-1,2-thiazol-3-ol is a palladium acetate catalyst that is used in the palladium-catalyzed synthesis of isothiazoles. It reacts with olefins to form (4-bromo)isothiazoles. 4-Bromo-1,2-thiazol-3-ol has been found to be effective for the synthesis of different types of isothiazoles.

<p>Pyrazolo[1,5-a]pyridine-3-carbonitrile is a crystalline solid in the form of an amorphous or polymorph. It has been shown to inhibit the kinase activity of protein tyrosine phosphatases and may be useful for the treatment of gastrointestinal disorders. The compound has also been shown to have antioxidant properties, which may be related to its ability to inhibit oxidative phosphorylation by inhibiting the mitochondrial membrane potential. Pyrazolo[1,5-a]pyridine-3-carbonitrile has also been shown to suppress proliferation and induce apoptosis in some types of cancer cells. This compound can serve as a nitrogen source for microbial growth and can inhibit bacterial growth by acting as an inhibitor of indolizine synthesis or nitrogen fixation.</p>

<p>Versatile small molecule scaffold</p>

<p>Bis[(6-methylpyridin-2-yl)methyl]amine is a monoxide that is used as an electrocatalyst for the reduction of nitrite to nitric oxide. Bis[(6-methylpyridin-2-yl)methyl]amine is able to catalyze the conversion of an electron from a proton donor to a sulfide substrate, which generates a geometrical change in the molecule. The bis[(6-methylpyridin-2-yl)methyl]amine molecule has acidic properties and can be used in coordination chemistry as it can coordinate with gold electrodes. This compound also has been shown to have nitrite reductase activity, which may be due to its ability to reduce molecular oxygen.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

2-Pentyl-2-cyclopenten-1-one is a stereoselective reaction product. It is synthesized by reacting cyclopentyl amines with sodium carbonate in acidic solution. The reaction is carried out at room temperature and the optimal reaction time appears to be 18 hours. This compound reacts with chloride to form an acid chloride, which undergoes dehydration to form the desired product. The resulting chemical structures are shown below.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>5-Methyl-1-phenylhexan-1-one is an antiviral agent that inhibits the infectivity of human immunodeficiency virus (HIV). It has been shown to be potent against HIV. The antiviral effect of 5-Methyl-1-phenylhexan-1-one is due to its ability to inhibit the action of HIV reverse transcriptase, which is an enzyme that catalyzes the synthesis of viral DNA from viral RNA. It is a 6 membered heterocycle with aspartyl and cyclopentyl rings. 5-Methyl-1 phenylhexan-1 one has not been tested for mutagenicity or carcinogenicity.</p>

Versatile small molecule scaffold

<p>8-Oxononanoic acid is a fatty acid that is found in the human body. It has been shown to have health effects such as decreasing the risk of cancer and lowering the rate of cardiovascular disease. 8-Oxononanoic acid is a coeluting compound, which means that it shares properties with other molecules. It has been shown to inhibit the growth of cancer cells by inhibiting tyrosinase, β-glucosidase, and lipid biosynthesis. 8-Oxononanoic acid also inhibits the production of lipids by blocking the enzyme acetyl-CoA carboxylase (ACCase). This enzyme catalyzes the conversion of acetyl-CoA into malonyl-CoA, which is then used in fatty acid synthesis.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Thiophen-3-amine hydrochloride is a heterocyclic amine that is structurally related to quinaldine. It has shown nitro transfer and nitroso transfer, which are mechanisms for the formation of nitro and nitrosamines. Thiophen-3-amine hydrochloride has low energy, which makes it an excellent candidate for rechargeable batteries. The amines in this compound have affinity for functional groups on the backbones of polymers and monomers, making them useful in research and optimization.</p>

Versatile small molecule scaffold

<p>2-(Carboxymethyl)-1H-pyrrole-3-carboxylic acid (CMPC) is an acid ethyl ester of 2-(carboxymethyl)-1H-pyrrole-3-carboxylic acid. CMPC is a reactive chemical that can be used as a raw material in the preparation of pharmaceuticals. It has anti-inflammatory properties and can be used in the treatment of inflammation, pain, and fever. Hydrolysis of CMPC with triethylamine and chloride yields the corresponding diester, which has anti-inflammatory properties. The hydrated form of CMPC reacts with ethylene to produce antiphlogistic effects, which may be due to its ability to inhibit prostaglandin synthesis.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>