Building Blocks

<p>N-(3-Cyanophenyl)acetamide is a hydrogen-bonding molecule that has been detected in the gas phase. It has also been observed to interact with water, forming hydrogen bonding interactions and solvatochromism. The equilibrium of N-(3-cyanophenyl)acetamide can be shifted by changing the solvent conditions and pH. This molecule has three conformations when it is in the gaseous phase, including a planar conformation. In addition, N-(3-cyanophenyl)acetamide can be used as a probe for determining hydrogen bonding interactions and conformations due to its ability to form hydrogen bonds with other molecules.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2,2-dimethylhex-5-enoic acid is an organic compound that belongs to the class of aldehydes. It can be synthesized by decarboxylation of 2,2-dimethylhexane. The selectivity is high and the functional groups are already present in the molecule. This reaction is a decarboxylative annulation and it requires a catalyst. This synthesis has been shown in chemistry textbooks as an example of a functional group transformation.</p>

<p>Versatile small molecule scaffold</p>

<p>Spiro[1,3-dioxolane-2,8'-pentacyclo[5.4.0.0²,⁶.0³,¹⁰.0⁵,⁹]undecan]-11'-one is an organic compound that has a ketal group in its structure. It is also a hydrogen bond donor and a reductive coupling agent with properties of intramolecular hydrogen bonding and dimerization. The intramolecular hydrogen can be found in the ring of the spiro[1,3-dioxolane-2,8'-pentacyclo[5.4.0.0²,⁶.0³,¹⁰.0⁵,⁹]undecan]-11'-one that is bonded to the ketal group as well as on the benzene ring on the other side of the molecule when it is bound to another spiro[1</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Depramine is a monoamine reuptake inhibitor that inhibits the reuptake of norepinephrine, dopamine and serotonin by blocking their respective transporters. Depramine has been shown to have therapeutic potential in the treatment of cancer. It has also been shown to be effective in the prevention of symptoms of depression. Depramine is not active against iontophoresis, which may be due to its insoluble nature and lack of film-forming properties.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>4-Formyl-N,N-dimethyl-benzamide is a potent tyrosine kinase inhibitor. It is a pyridine derivative that binds to the ATP binding site of the enzyme and inhibits its activity. This results in decreased cellular proliferation and lower levels of protein synthesis. 4-Formyl-N,N-dimethyl-benzamide has shown to be effective at inhibiting the growth of tumour cells when combined with chemotherapy, but has not been evaluated for efficacy in treating other diseases. The pharmacokinetic profile of this drug is not well known, as it has not been studied in humans.br&gt;</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Butyl chloromethyl carbonate is a nitro-substituted aliphatic hydrocarbon that is metabolized by the body to form an active compound. It has been used in the treatment of infectious diseases, such as HIV or cancer. Butyl chloromethyl carbonate inhibits the growth of bacteria and viruses, and has been shown to be effective against human immunodeficiency virus (HIV) and papilloma virus. This drug binds to pyrimidine compounds and heterocycles, which inhibit the synthesis of DNA and RNA. The pharmacokinetics of this compound are dependent on its metabolism by carboxylates and aromatic hydrocarbons.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Ethyl 2-anilino-4-oxo-4,5-dihydro-3-furancarboxylate is a reactive compound that inhibits the mitochondrial membrane potential. It also has anti-tumor and anti-proliferative activities. This compound's membrane potential inhibitory effect is due to its ability to generate reactive oxygen species (ROS) in a mitochondria membrane. ROS are toxic and can lead to cell death. The anti-proliferative activity of ethyl 2-anilino-4-oxo-4,5-dihydro-3-furancarboxylate may be due to its ability to activate caspase 3.

<p>Versatile small molecule scaffold</p>

Ethyl isethionate is a chemical compound that belongs to the group of ethyl esters. It has been used as an additive in food, and it has also been shown to be effective against L1210 and other cancer cells. Ethyl isethionate has been shown to have anti-inflammatory properties and can inhibit prostaglandin synthesis. The linear regression analysis demonstrated that fatty acids can react with anions to form esters, which may be the mechanism by which ethyl isethionate was formed. Ethyl isethionate also reacts with fluorine, which results in the formation of fluoroethyl esters. This reaction may lead to the formation of busulfan, a chemotherapy drug used for treating leukemia and Hodgkin's disease. Another possible route for the synthesis of ethyl isethionate involves alkylation of long-chain chlorides with fatty acids or trifluoromethanesulfonic acid.

<p>4-Amino-N-(2-aminophenyl)-benzamide (4ANAP) is a small molecule that inhibits inflammatory bowel disease. It has been shown to have anti-inflammatory effects and to be a potential biomarker for colorectal adenocarcinoma. 4ANAP binds to the EGF receptor on the cell surface, which prevents its activation by EGF and thereby blocks cellular proliferation. 4ANAP has been shown to bind with high affinity to other receptors such as those found in autoimmune diseases and cancer cells. The anti-inflammatory properties of 4ANAP are due to its ability to inhibit the production of proinflammatory cytokines such as IL1β, IL6, TNFα, and IL8. This drug also inhibits the production of reactive oxygen species in neutrophils and macrophages, thereby reducing oxidative injury in inflamed tissues.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>