Building Blocks

<p>Versatile small molecule scaffold</p>

<p>2,2-Dimethylcyclobutane-1-carboxylic acid is a synthetic chemical that can be used as a biodiesel fuel additive. It is produced by the reaction of cyclohexanol and ethylene oxide. This compound has been shown to have redox potentials in the range of -0.03 V to -0.07 V, which makes it useful in synthesizing lipase and fatty acids. 2,2-Dimethylcyclobutane-1-carboxylic acid also has sulfonic acid groups that are reactive with metal surfaces, such as gold or silver electrodes and hydrochloric acid for pharmaceutical formulations. This compound has regulatory properties that can be used for preservatives or other functional purposes in pharmaceutical formulations. 2,2-Dimethylcyclobutane-1-carboxylic acid is also an acid catalyst in laboratory experiments involving regulatory pathways.br&gt;br&gt;<br>2,2-Dimethylcyclobutane</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Azocan-3-amine is a third-generation, small molecule inhibitor of the ErbB family of receptor tyrosine kinases. It was discovered by a team of scientists at AstraZeneca and has been evaluated in clinical trials for the treatment of various cancers. Azocan-3-amine inhibits the activity of EGFR and its two most common mutations, T790M and C797S. This drug is currently in Phase I/II trials for EGFR T790M mutation positive non-small cell lung cancer (NSCLC) and metastatic breast cancer patients with EGFR c797s mutation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Methylcycloheptanamine (NMCA) is a pyrimidine compound that has inhibitory activities against hexamethylenetetramine and aminopeptidase. NMCA also inhibits the immunosuppressive effect of cyclophosphamide, which is an anticancer drug. NMCA has been shown to be effective in treating autoimmune diseases and cancer. The inhibitory activity of NMCA on hexamethylenetetramine and aminopeptidase is due to its ability to react with these enzymes in nanomolar concentrations. Structural analysis has shown that NMCA binds to the enzyme by coordinating with the catalytic metal ions and the amino acid residues of the active site, forming a covalent bond with glutamic acid residue. This binding prevents substrate binding or product release, inhibiting enzyme activity.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2-aminophenoxy)ethanol (2-APOE) is an alkylating agent that has been shown to be mutagenic in bacterial strains. It is a direct-acting mutagen and can cause mutations by reacting with DNA bases or proteins. It also has the ability to cleave DNA chains, which may lead to carcinogenic effects. This product is not known to cause cancer in humans and has been found to be safe for use as a food additive at levels up to 0.1%. 2-APOE is used in the production of other chemicals and as an intermediate in chemical synthesis.</p>

<p>2-Acetyl-3-bromothiophene is a dihedral molecule that has been shown to have photovoltaic properties. The molecule has two primary amines, which function as electron donors and an interleukin, which functions as an electron acceptor. 2-Acetyl-3-bromothiophene also has a chalcone group, a carbonyl group, and yields of primary alcohols. In the experimentally determined vibration frequencies, the most intense peaks were found at 1760 cm−1 (vibrational) and 1128 cm−1 (rotational).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Benzyl-2-methylpropan-1-amine is a phosphorous acid regulator that is used as a moiety in the synthesis of debenzylated benzyl amines. It can be used to regulate the pH of alkali metal esters and metal halides. N-Benzyl-2-methylpropan-1-amine also has been found to enhance the rates of amine reactions and promote the formation of ketones. This compound is also an ammonium salt with an oxidative effect on most organic substances.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Allyl-2-bromobenzene is an organic solvent that is used in the synthesis of fatty acids and bromophenols. It is a gaseous liquid at room temperature and pressure, but it can be condensed to liquid form by cooling. 1-Allyl-2-bromobenzene reacts with polydimethylsiloxane to produce amides or chlorides. The reaction proceeds under conditions where there are no competing reactions such as alkylation or biomolecular oxidation. It has been used extensively in the synthesis of fatty acid esters, amides, and nitriles. This organic solvent is volatile at room temperature and pressure and its boiling point is below 100 degrees Celsius. 1-Allyl-2-bromobenzene has a low viscosity and high surface tension which make it useful for certain types of chemical reactions on surfaces such as in the production of reaction products from naphthalene.br&gt;br&gt;</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 2-methoxyethanecarboximidate hydrochloride is an amido amide with antibacterial activity. It is a carboxylic acid compound and an isomer of ethyl 2-methylpropanoate. This active form has been shown to inhibit bacterial growth by binding to the enzyme ribonucleotide reductase, which converts ribonucleotides into deoxyribonucleotides. The antimicrobial activity of this agent has been demonstrated in vitro against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, Streptococcus pyogenes, and Enterobacter cloacae. Ethyl 2-methoxyethanecarboximidate hydrochloride also inhibits the production of bacterial endotoxin and has shown antibiotic activity against Gram-positive organisms.</p>

<p>9-Oxo-9,10-dihydroacridine-2-carboxylic acid is a fatty acid oxidation product that has been shown to induce apoptosis in the mitochondria of tumor cells. This process is mediated by the release of cytochrome c from the mitochondria into the cytosol. It also binds to antigens in the extracellular matrix and induces autoantibodies against these antigens. 9-Oxo-9,10-dihydroacridine-2-carboxylic acid has been found to bind to caspase family members and potentiate their activity. 9oxoacridine 2 carboxylic acid is also a potential antitumor agent that shows histological evidence of tumor regression in rats injected with sarcoma 180 cells.<br> 9oxoacridine 2 carboxylic acid also binds to DNA and inhibits protein synthesis by blocking transcriptional initiation at G</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-5-nitronicotinic acid is an inhibitor of HIV-1 reverse transcriptase. It binds reversibly to the active site of the enzyme and blocks its ability to synthesize DNA, thus inhibiting HIV replication. 2-Chloro-5-nitronicotinic acid also inhibits the activity of wild type and mutant forms of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with high potency. This drug has been shown to be effective against nevirapine resistant HIV strains. The molecular modeling studies suggest that 2-chloro-5 nitronicotinic acid binds to a hydrophobic pocket in the active site of HIV reverse transcriptase, which is different from other inhibitors such as AZT, ddI, and ddC.</p>

<p>2-Chloro-5-hydroxynicotinic acid is a chemical compound that has been isolated from the bark of the plant Cinchona officinalis. It is an intermediate in the biosynthesis of quinine and other cinchona alkaloids. 2-Chloro-5-hydroxynicotinic acid is also used as an intermediate in the synthesis of other compounds, including herbicides and pesticides.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Benzofuran-2-carbohydrazide (1BFC) is an antibacterial agent that belongs to the class of nitrogenous compounds. It is a member of the benzofuran derivatives and has been shown to have significant antifungal activity against flavus, cleavage activity against s. aureus and staphylococcus, and hypoglycemic activity in mice. 1BFC has been found to be more active than fluconazole against Candida albicans, but less active than fluconazole against Saccharomyces cerevisiae.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>