Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-[4-(Prop-2-en-1-yloxy)phenyl]acetic acid, also known as propacetamol, is a nonsteroidal anti-inflammatory drug. It is an analgesic and a weak dehydrating agent. Propacetamol is used to relieve moderate or severe pain, such as that caused by headache, migraine, dental pain, or neuralgia. The chemical structure of propacetamol contains an ester which can be hydrolyzed to give the corresponding carboxylic acid and alcohol. 2-[4-(Prop-2-en-1-yloxy)phenyl]acetic acid has been shown to have antiplatelet properties and has been used to prevent thrombosis in patients undergoing coronary artery bypass grafting surgery. This drug also has the ability to inhibit epoxidation reactions that are catalyzed by cytochrome P450 enzymes.</p>

<p>2-{4-[(Oxiran-2-yl)methoxy]phenyl}acetic acid is an organic compound with the chemical formula CH3COCH2CH=OCH2C6H5. This white solid is a derivative of phenylacetic acid. It is used as a building block for the synthesis of esters, amides, and other derivatives. It can also be used to synthesize epoxides and amines by epoxidation or amine, respectively. 2-{4-[(Oxiran-2-yl)methoxy]phenyl}acetic acid has been shown to inhibit the growth of Pseudomonas aeruginosa and Staphylococcus aureus isolates. The ester group on this molecule may contribute to its anti-bacterial activity.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>N-{[(4-Chlorophenyl)carbamothioyl]amino}-2-phenylacetamide is a small molecule that has been shown to be expressed in mammalian cells. It binds to the target enzyme and stabilizes the protein, which prevents it from denaturing. N-{[(4-Chlorophenyl)carbamothioyl]amino}-2-phenylacetamide has been shown to have beneficial effects on metabolic disorders such as aciduria and can be used as a chaperone when treating life threatening diseases. Structural analysis of this compound reveals coordination chemistry interactions with galactose.</p>

<p>1-{4-[(2-Methylphenyl)methoxy]phenyl}ethan-1-one is a small molecule that has been shown to inhibit the activity of ion channels. It binds to the receptor site, which is located on the outside of the cell membrane. This binding prevents the passage of ions through the channel, thereby preventing electrical signals from being transmitted by ligand gated ion channels. 1-{4-[(2-Methylphenyl)methoxy]phenyl}ethan-1-one is also an inhibitor of peptides and can be used as a research tool in cell biology and as an antibody in immunology.</p>

Versatile small molecule scaffold

2-(5-Chloro-2-nitrophenyl)acetonitrile is a n-oxide and carbanion that has been used as a model for the study of acrylonitrile. 2-(5-Chloro-2-nitrophenyl)acetonitrile can be synthesized by nitrating aniline with nitric acid, followed by oxidation with potassium permanganate. The resulting product is then reacted with acrylonitrile in the presence of an acid to form 2-(5-chloro-2-nitrophenyl)acrylonitrile. This compound is unstable and decomposes when it is heated to 150 degrees Celsius.

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

4-(2-Nitrophenyl)-2-oxobut-3-enoic acid is an asymmetric synthesis of benazepril, a drug used to treat congestive heart failure. It is synthesized from formate and formaldehyde. The synthesis of 4-(2-nitrophenyl)-2-oxobut-3-enoic acid has been shown to be effective in reducing the severity of congestive heart failure in rats by inhibiting the production of l-glutamate. This compound also inhibits transamination reactions and glutamate dehydrogenase, which are enzymes that are involved in ammonia detoxification.

<p>1-(Prop-2-en-1-yl)cyclohexane-1-carboxylic acid is a functionalized, chloride salt. It has been shown to be an allylating agent in the presence of ultrasonication.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Imidazol-1-yl-butyric acid is a coordination polymer with a carboxylate group. It can be synthesized by the reaction of butyric acid with isopropoxide in the presence of titanium tetrachloride and benzimidazole. The resulting product has a dimerization ability, which allows it to bind to metal ions. This binding leads to chelation and polymerization, which have been shown to have many applications, including pharmaceuticals and biomedicine.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>1-Benzylpyridin-4(1H)-one is an organic compound that belongs to the group of benzyl compounds. It is a colorless oil with a sweet, floral odor. 1-Benzylpyridin-4(1H)-one is used as an intermediate in organic chemistry and reacts with alkenes, sulfoxides, and sulfides to form intermediates. It also reacts with alkynes to form triflic acid esters. The hydrolysis of this compound produces pyridine and benzaldehyde. This compound has been used in the synthesis of sulfoxide antibiotics such as cefotaxime and ceftazidime.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Benzyloxy(methylidene)amine (BAM) is a selective and stereoselective mediator for the asymmetric synthesis of guanine. It is an amine that has been shown to cause carcinogenesis in rats. In addition, BAM is reactive and can be used at nanomolar concentrations in reactions to monitor the progress of the reaction. This mediator can form a radical coupling with piperidine, which produces a ferrocenyl-substituted guanosine.</p>

2-Chloro-6-methoxyphenol is an organic compound that is used as a sample pretreatment agent. It is used in the preparation of fatty acids, which are important in the production of polymers and other materials. The reactivity of this compound can be described by a reaction mechanism involving hydroxy groups, which allows it to react with water to form 2,4-dichlorophenol and hydrochloric acid. 2-Chloro-6-methoxyphenol has been shown to inhibit the growth of many bacterial strains, including those found in wastewater. This product is also nontoxic and nonflammable. It does not contain any toxic impurities or volatile organic compounds (VOCs).

<p>2,4-Dichloro-6,7-dimethoxyquinoline is a quinoline compound that has been used to investigate the enzyme methyltransferase. This chemical was found to bind to the quinoline site of the enzyme and had a high homology with other inhibitors of this type. 2,4-Dichloro-6,7-dimethoxyquinoline also showed potency against a number of methyltransferases and inhibited methylation reactions in vitro. The thermodynamic parameters for binding were determined using isothermal titration calorimetry.</p>

<p>Versatile small molecule scaffold</p>