Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Miltefosine is a cell-toxic agent that is used to treat leishmaniasis. Miltefosine has been shown to be active against the promastigotes and intracellular amastigotes of Leishmania infantum. It also has antileishmanial activity against L. major, L. tropica, and L. mexicana, as well as against the human parasite Leishmania donovani. Miltefosine is an analog of 2-(hexyloxy)ethanol that can be conjugated with a variety of functional groups for use in drug delivery systems, such as liposomes and polymeric micelles. This agent exhibits hemolytic activity when introduced into erythrocytes in vitro, which may be due to its ability to inhibit protein synthesis at the ribosome level by binding to the 50S subunit of the ribosome's large subunit and inhibiting peptide

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 2-[(2-phenylethyl)amino]acetate is a prodrug of prostaglandin E2. It is used as an anti-inflammatory agent and has been shown to have both anti-inflammatory and analgesic effects. The drug binds to the prostaglandin E receptor, which in turn activates certain enzymes that cause the production of prostaglandin E2. Prostaglandin E2 is a hormone that plays an important role in inflammation, pain, and fever. It also causes blood vessels to open wider and stimulates the release of histamine from mast cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Benzyl(ethoxy)amine is a pyrimidine compound that is used as a pharmaceutical preparation. Benzyl(ethoxy)amine has been shown to be beneficial in the treatment of tuberculosis, syncytial virus infection, and congestive heart failure. It is synthesized by reacting benzyl alcohol with ethylene diamine. The two functional groups of benzyl (ethoxy)amine are hydroxybenzoic acid and the amine group. The amine group is responsible for receptor agonism, cell apoptosis, and inhibition of viral replication. The hydroxybenzoic acid group has been shown to inhibit the growth of bacteria such as Streptococcus pneumoniae and Mycoplasma pneumoniae. This drug also inhibits HIV-1 reverse transcriptase activity.<br>END&gt;</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>5-(1H-Benzimidazol-2-yl)pyridin-2-ol is a proapoptotic agent that is synthesized from the reaction of benzimidazole with 2-chloroacetic acid. This compound was found to be cytotoxic and proapoptotic in ovarian cancer cells, as it inhibits DNA polymerase activity and induces apoptosis. 5-(1H-Benzimidazol-2-yl)pyridin-2-ol has been shown to activate caspase 3, which may lead to the activation of downstream events such as mitochondrial membrane permeabilization, cytochrome c release, and caspase 9 activation. The mechanism of action for this drug is still under investigation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

N-(2-aminoethyl)prop-2-enamide hydrochloride is a monomer that has a molecular weight of about 146.1 g/mol and a chemical formula of C5H14N3O3Cl. It is synthesized through an experimental process involving the reaction of propanoyl chloride with 2-aminoethylamine. The chemical structures of this monomer are shown in Figure 1, which also reveals its resonance, kinetic, and magnetic properties. N-(2-aminoethyl)prop-2-enamide hydrochloride has a viscosity of about 0.7 mPa·s at 25°C and is soluble in water, ethanol, chloroform, ether, and benzene.

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Methyl 2-methylazulene-1-carboxylate is a natural product that is found in the leaves of the "Mentha" species. It has shown anti-inflammatory, analgesic and antipyretic properties. Methyl 2-methylazulene-1-carboxylate is a cost effective analog of azulene and is used in medicinal preparations. It can be obtained by thermolysis of an ether or vinyl ether with a lactone. This compound has been shown to have optical (light) activity when cycloaddition reactions occur at the double bonds of the molecule. Tropolones are related compounds that also show this optical property.

<p>1-(4-Methoxyphenyl)pyrrolidine is an amide that is structurally related to buspirone and diazepam. It has been shown to have a high affinity for serotonin receptors. 1-(4-Methoxyphenyl)pyrrolidine has been found to be an antagonist of diazepam in the brain, and it also inhibits the binding of lidocaine to the sodium channel. In addition, 1-(4-Methoxyphenyl)pyrrolidine has pharmacological properties similar to those of procaine and lidocaine, which are used as local anesthetics. This drug was found to be acutely toxic in rats, but not at levels that would be harmful for humans.</p>

<p>2-(Pyrrolidin-1-yl)pyridine is a chiral compound that belongs to the group of nucleophilic compounds. It can be synthesized in two different configurations, as either the erythro or threo isomer. The synthesis of 2-(pyrrolidin-1-yl)pyridine requires an asymmetric synthesis and involves the reaction of an acyl chloride with 2,6-dichloropyrimidine. The erythro isomer has been shown to have receptor activity at cb2 receptors and has been shown to reduce inflammation in animal models. The threo isomer has been shown to have reduced activity at cb2 receptors and does not show anti-inflammatory properties.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2-Tributylstannylthiophene is a molecule that is used in organic synthesis. It is synthesized by the cross-coupling of 2-bromothiophene and tributyltin chloride. This molecule has been shown to be thermochromic, meaning that it changes color with a change in temperature. The color changes from yellow at lower temperatures to red at higher temperatures. 2-Tributylstannylthiophene has been shown to have optical properties, such as fluorescence and absorption, which are dependent on its molecular structure. It also has chemical properties, such as acidity, which can be altered by substituents on the carbon atoms of the molecule. 2-Tributylstannylthiophene can be used as a monomer for an organic material with constant optical properties because it does not undergo any reactions when exposed to inorganic acids or bases.</p>

<p>N-(1,3-Thiazol-2-yl)pyridin-2-amine is a tyrosine kinase inhibitor that can be used to treat cancer. It was found to inhibit the growth of tumor cells by interfering with their ability to make new proteins. The drug also has a low molecular weight and a high solubility in water, which makes it suitable for intravenous administration. N-(1,3-Thiazol-2-yl)pyridin-2-amine inhibits protein kinases through competitive binding to the ATP binding site on the enzyme's active site. It has an analog profile that includes low molecular weight and high solubility in water, making it suitable for intravenous administration. Additionally, it has been shown that this drug is selective for receptor tyrosine kinases over other types of protein kinases (e.g., serine/threonine), while still exhibiting cross covalent coupling with piperazine</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>