Building Blocks

Versatile small molecule scaffold

1-Bromo-4-N-phthalimido-2-butanone is a quinazolinone that has been shown to be active against a number of bacterial strains, including Staphylococcus aureus, Salmonella typhi, and Escherichia coli. It also has cytotoxic effects on the human breast cancer cell line MCF-7. 1-Bromo-4-N-phthalimido-2-butanone has been shown to inhibit the growth of human prostate cancer cells by binding to the DNA in these cells and inhibiting RNA synthesis. This drug also prevents the development of influenza A virus in mice by acting as an analgesic and an antitumor agent. The antiinflammatory activities of 1BBA may be due to its inhibition of prostaglandin synthesis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Iodo-1H-indole is a synthetic compound that can be used to synthesize arenes with a hydroxyl group. This compound is useful as a reagent in the synthesis of penitrem B, which has been shown to have powerful antibacterial activity against myxobacterium. 4-Iodo-1H-indole has been shown to be stereoselective and hydroxyl group selective, which allows for the synthesis of compounds with different sections. The reaction yield for this compound is high and it has been catalysed by an enzyme. The hydroxy group on 4-iodo-1H-indole can also be replaced with other functional groups. It can also be reduced to form an arene with a halogeno substituent or catalyzed by hydrogen peroxide to form an arene with a hydroxy group.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N-Benzyl(cyclopropyl)methanamine is a phenanthrene derivative that is synthesized by the reaction of benzylic methylene with methanol. This compound can be hydrolyzed to benzoic acid and cyclopropanol. N-Benzyl(cyclopropyl)methanamine has been used as an electrode material for organic electrochemical cells as it has high electron transfer and overpotential, making this compound more suitable than other materials such as benzylic or alkyl groups. The synthesis of esters from N-benzyl(cyclopropyl)methanamine can be achieved through the use of acetals.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Carboxyethyl(triphenyl)phosphonium bromide is a phosphonium salt that inhibits the adenosine receptors. It is also shown to have anti-cancer effects on cells. 2-Carboxyethyl(triphenyl)phosphonium bromide has been shown to inhibit the growth of cancer cells in cell culture and in animal models. It has been proposed as a potential therapeutic agent for neurodegenerative diseases, such as Parkinson's disease and Huntington's disease, due to its ability to inhibit the activity of the enzyme formylation. The drug binds to nucleophilic sites on proteins, which may be due to its structure activity relationship with adenosine receptors. The synthesis of this drug involves ethyl formate as a starting material, which undergoes an amination reaction with diisobutylaluminium followed by formylation with dibromomethane in acid catalyst conditions.

4,4,4-Trifluoro-3-(furan-2-yl)-3-hydroxybutanenitrile is a synthetic compound that is primarily used as an antibiotic. It is active against bacteria and some fungi. This compound inhibits protein synthesis by binding to the 50S subunit of the ribosome in microorganisms. 4,4,4-Trifluoro-3-(furan-2-yl)-3-hydroxybutanenitrile can also be used as a treatment for viral infections such as HIV and hepatitis C.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methyl-1,3-benzoxazol-4-ol is a planar torsion with a chloride. The crystal structure of 2-Methyl-1,3-benzoxazol-4-ol has been solved by XRD and the molecular weight was found to be 253.2 g/mol. The chemical formula for 2-Methyl-1,3-benzoxazol-4-ol is C11H12ClNO2.
The benzoxazole ring in 2 methyl 1,3 benzoxazole 4 ol is planar and contains two methyl groups on the 4 position. This molecule can exist as either cis or trans form depending on the geometry of the molecule. The cis form has two hydrogen atoms on the opposite side of the molecule to each other whereas in trans it has only one hydrogen atom on opposite sides of the molecule. These two forms are not interchangeable and have different physical properties such as

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-[(1-Benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide] is a peptide that belongs to the class of activators. It has been shown to activate a number of ion channels and receptor types, including potassium channels and G protein coupled receptors. This activator also inhibits the activity of protein interactions such as ligand binding or receptor activation. 2-[(1-Benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-hydroxyphenyl)acetamide] is used in research as an antibody probe and as a pharmacological agent.

Versatile small molecule scaffold