Building Blocks

{Bicyclo[6.1.0]non-4-yn-9-yl}methanol is a chemical compound that has been shown to enhance the activity of albumin in cell culture, which may be due to its ability to bind to the serum albumin and form a stable complex. {Bicyclo[6.1.0]non-4-yn-9-yl}methanol has also been used as a labeling agent and photophysical probe, with classically labeled compounds being more sensitive than residues or amides. This chemical can also be used as a substrate for genetically engineered synthetases that are useful in studying lysosomal degradation pathways and protein synthesis in cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Chloro-3-(4-fluorobenzenesulfonamido)benzoic acid (CAS No. 729561-80-2) is a custom synthesis chemical that has been modified to include fluorine, methylation, and click chemistry. It is a white solid with a melting point of 103°C. This compound is an oligosaccharide and polysaccharide that can be used in the synthesis of complex carbohydrates. This chemical is also useful for the modification of saccharides, sugars, and monosaccharides.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Acetamides are a class of organic compounds that are used as solvents and pharmaceuticals. They have been shown to have diastolic pressure-lowering effects, with the mechanism of action being inhibition of the enzyme activity that produces prostaglandin E2. Acetamides also have chemoattractant properties, which may be due to their ability to inhibit the production of chemokines. Acetamides are also known to exhibit antiinflammatory activity and can be used in experimental models for neurodegenerative diseases such as Alzheimer's disease. Acetamides can also lower collagen synthesis in fat cells, which may be useful for the treatment of obesity. Acetamides have been shown to bind to glucocorticoid receptors and regulate gene expression by affecting transcriptional factors such as NF-κB.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Ethyl-4-methylaniline is a potent antibacterial agent that is used to treat infections caused by staphylococcus. 3-Ethyl-4-methylaniline inhibits the growth of bacteria by binding to the enzyme polymerase, which is needed for DNA replication. This binding prevents the polymerase from reading the genetic code and synthesizing new proteins. The alkylation reaction also inhibits s. aureus, an organism that causes tooth decay and other diseases in humans. 3-Ethyl-4-methylaniline has been shown to be a byproduct of demethylation reactions and can inhibit organisms such as subtilis and Klebsiella pneumoniae.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Oxa-3,9-diazaspiro[5.5]undecan-2-one is a carbamate that has shown to be an antagonist of the androgen receptor. In vitro studies show that 1-Oxa-3,9-diazaspiro[5.5]undecan-2-one inhibits the proliferation of cells in hyperproliferative disorders. This compound has been shown to have antiviral effects against herpes simplex virus type 1 (HSV1) and 2 (HSV2). The antiviral potency of this drug is increased by template mutation in the viral genome.

5-Bromo-2-methyl-1-benzofuran is a phenyl ring with a furan moiety. The molecule has an average length of 1.5 Å and contains dihedral angles that are close to 90°. 5-Bromo-2-methyl-1-benzofuran is stabilized by two substituents on the phenyl ring, which are methyl groups on the benzene rings. This molecule can form hydrogen bonds with water molecules, as well as other polar molecules such as alcohols and acids. The crystal structure of this molecule is also stabilized by interactions between the phenyl and benzofuran moieties.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold