Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,3-Dimethyl-1,4-dioxan-2-one (DMDO) is a chiral compound that is used in organic synthesis as a chiral auxiliary. This molecule has been shown to be useful for the stereoselective polymerization of lactones, enolates, amides and aldehydes. DMDO has also been investigated for its ability to form spindle-like polymers with glycolide and optical activity. 3,3-Dimethyl-1,4-dioxan-2-one is soluble in common organic solvents such as chloroform and dichloromethane at room temperature and can be used for the preparation of microparticles with a diameter up to 50 µm. The high yield of this compound makes it an attractive alternative to other synthetic methods.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-[(6-Amino-1H-purin-8-yl)amino]ethan-1-ol (6APA) is a prodrug that is metabolized by the liver to 6-mercaptopurine (6MP). It is an antiinflammatory drug that has been shown to suppress collagen synthesis and inhibit the activity of proteases. 6APA is also used as a diagnostic agent for systemic diseases, such as reactive arthritis and systemic lupus erythematosus. This compound can be used in the treatment of inflammatory diseases, such as rheumatoid arthritis and Crohn's disease, due to its ability to inhibit the production of inflammatory compounds. The drug binds to affinity ligands which are associated with various proteins, including collagen. This binding prevents the formation of new proteins, which leads to cell death by inhibiting protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1H-1,3-Benzodiazol-2-yl)-1-phenylethanone is an unsymmetrical phenacyl chloride that is used in the synthesis of drugs. The generation of acidolysis products and the formation of active methylene compounds are catalyzed by 2-(1H-1,3-benzodiazol-2-yl)-1-phenylethanone. This compound is also used for the preparation of chlorides and methylhydrazones. Preparative methods for this compound involve thionyl chloride, hydrochloric acid, and phenylhydrazone.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Cyclohexyl-1H-1,3-benzodiazole is a synthesized chemical compound belonging to the class of amide benzimidazoles. It has been shown to be an effective inhibitor of xanthine oxidase and an inducer of apoptosis in leukemia cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,2,3,4-Tetrahydroquinoline-2-carboxamide is a potent inhibitor of the enzyme histidine decarboxylase. It has been shown to have significant cytotoxicity against certain cancer cells and inhibit the proliferation of other cells in culture. 1,2,3,4-Tetrahydroquinoline-2-carboxamide has shown a potent inhibition of serotonin synthesis and significant anti-inflammatory effects in animal models. This drug also inhibits the production of retinoic acid by binding to the retinoic acid receptor subtype II receptor. In addition to its therapeutic effects on inflammation and bone mass, 1,2,3,4-tetrahydroquinoline-2-carboxamide has been shown to be effective in treating congestive heart failure and glomerulonephropathy due to its ability to inhibit angiotensin II type I receptors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,4-Dichloro-5H,6H,7H-cyclopenta[D]pyridazine is a quaternary ammonium salt that has been shown to be an effective antibacterial agent. It binds to the bacterial cell wall by competitive inhibition and prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. 1,4-Dichloro-5H,6H,7H-cyclopenta[D]pyridazine has also been shown to be effective against methacrylate microbeads in vitro. This drug is used as a disinfectant on polystyrene surfaces and can be used in combination with benzoyl peroxide or ethanol and benzoyl chloride to produce a disinfectant foam.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Oxo-3-(4-phenylphenyl)propanoic acid is a chiral molecule that can be synthesized from 4-bromocinnamic acid and 2,3-dichlorobenzoyl chloride in two steps. The first step is an acid dehydrogenation of the 4-bromocinnamic acid to form the corresponding enol form. The second step is an arylation using 2,3-dichlorobenzoyl chloride. This compound has been found to be highly efficient and selective in its chemoenzymatic synthesis. Promiscuity of this compound has also been observed, which allows it to be used for the synthesis of various other compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>