Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,2-Dimethylbut-3-ynoic acid is an organic compound that can be synthesized from acetone. The chemical formula of this compound is C6H12O2. 2,2-Dimethylbut-3-ynoic acid has a boiling point of 157 degrees Celsius and a melting point of -87 degrees Celsius. It has the molecular weight of 136.19 g/mol and its density is 1.07 g/cm^3 at 25 degrees Celsius. This compound can be used as a precursor to other chemicals, such as butanediol or butyraldehyde, which are used in production processes for plastics and synthetic rubber.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(3-Nitrophenyl)acrylaldehyde is an organic compound that belongs to the class of aldehydes. It is used in the synthesis of halogenated compounds, such as dibromohexane, and in organic chemistry as a building block for the preparation of hydrophobic compounds. 3-(3-Nitrophenyl)acrylaldehyde reacts with benzene in an aldol condensation reaction to form 2,4-dinitrobenzaldehyde. This reaction may be catalyzed by acid or base. The efficiency of this reaction is increased when it is carried out at lower temperatures and higher pressures. The ring-opening reaction of 3-(3-nitrophenyl)acrylaldehyde with methanal also proceeds efficiently at lower temperatures and higher pressures.

Methyl 5-methyl-2-oxocyclohexane-1-carboxylate is a racemic compound with the chemical formula CH3(CH2)4CO2. The individual enantiomers are known as D and L methyl 5-methyl-2-oxocyclohexane-1-carboxylate. This compound is a sesquiterpenoid and has been found to inhibit the growth of certain bacteria, fungi, and parasites. The biological activity of this compound is due to its ability to interfere with protein synthesis by binding to the active site of enzymes that require a carboxyl group for their function. Methyl 5-methyl-2-oxocyclohexane-1-carboxylate can be found in nature as a mixture of two enantiomers, but it can also be synthesized in a racemic form.

2-Oxopyridin-1(2H)-yl)acetic acid is a colorless, crystalline solid that can be used as a reagent for organic synthesis. It has been shown to inhibit the growth of C. parapsilosis and T. tetracosane at low concentrations. 2-Oxopyridin-1(2H)-yl)acetic acid may have an inhibitory effect on the enzyme dehydrogenase, which catalyzes the conversion of hexadecanoic acid to hexadecenoic acid during lipid metabolism and is required for cell survival. This compound has also been shown to be effective against M. tuberculosis and M. avium complex, but not against other bacteria such as B. subtilis or S. aureus.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1H-Pyrazole-3,4-dicarboxylic acid is an organic compound that is a white solid. It is a proton acceptor and stabilizer in ammonium formate. In the presence of amide and cyanoformate, it has been shown to inhibit neprilysin activity. 1H-Pyrazole-3,4-dicarboxylic acid also has membrane properties and can be used as a viscosity modifier for polyphosphoric acid. This compound also has some acid moieties that can modulate its solubility in organic solvents.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-hydroxy-4-methoxy-2-nitrobenzoic acid is a synthetic antioxidant that is synthesised from α-tocopherol. It has been shown to be an effective scavenger of hydroxyl radicals and reactive oxygen species, which are involved in the oxidative degradation of biomolecules. 5-Hydroxy-4-methoxy-2-nitrobenzoic acid can be used as an antioxidant in food and cosmetics. This compound also reacts with linoleic acid, forming a phenolic product, which has antioxidant activity.

Benzofuran-5-ylmethanol is an aromatic ether that finds applications in various industries such as research chemicals, medicines, and catalysts. It is used as a building block for the synthesis of compounds like oxalyl glycine, aldehyde dimers, and trifluoroacetic acid. Benzofuran-5-ylmethanol also exhibits antiviral properties and has been studied for its potential in inhibiting viral replication. Additionally, it is a precursor for the synthesis of phenylethylamine derivatives and polyunsaturated fatty acids. With its diverse range of applications, Benzofuran-5-ylmethanol serves as a valuable compound in the field of organic chemistry and industrial processes.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Chloro-1-methyluracil is a nucleophilic acylating agent that reacts with primary amines to form N,N'-acylureas. It also reacts with chloride to form chlorinated derivatives. 6-Chloro-1-methyluracil has been shown to react with hydrogen peroxide in an acid solution to produce cyclen and aldehydes. The reaction scheme is shown below:

(1-Phenylcyclopropyl)methanol is an aromatic ketone that can be used in the synthesis of oxazaborolidines. It has been proven to be a good substrate for asymmetric syntheses, which are often used for the development of enantioselective reactions. The mechanism of this reaction is not yet fully understood, but it is thought that the C-O bond in (1-phenylcyclopropyl)methanol reacts with acetophenone to form an intermediate diketone. This intermediate then reacts with an electrophile such as sodium methoxide or methyl iodide to produce the desired product.

Methyl oxazole-2-carboxylate is a cyclic, chiral, methyl ester. It is a congener of the drug Valine and has been shown to have antitumor potential. The methyl oxazole-2-carboxylate is an amide with a cyclic peptide backbone and is synthesized from valine by way of an enzymatic reaction that converts the amino acid into a chiral, cyclic amide. This compound has demonstrated anticancer properties in vitro and in vivo. Methyl oxazole-2-carboxylate also has antiangiogenic activity which may be due to its ability to inhibit protein synthesis in tumor cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold