Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,5-Dioxopyrrolidin-1-yl formate is a solubilized ATP analog that has been clinically developed for the treatment of cancer. This drug binds to cell membranes and causes alkylation of the acidic phospholipids in the membrane, leading to increased permeability of the membrane and release of intracellular components. 2,5-Dioxopyrrolidin-1-yl formate also interacts with lysosomes and increases their acidity, which may lead to an increase in lysosomal enzyme activity. This drug has been shown to inhibit tumor growth in a mouse model by binding to erythrocytes while it was being simultaneously administered intravenously. The chemical structures of this drug are closely related to those of phaseolus, which is known for its anticancer effects.

N,N-Dimethylcyclohexanecarboxamide is an acid salt of besylate that is used as a drug for the treatment of hyperglycemia. It has been shown to have a rapid onset and short duration of action. The chemical name for N,N-Dimethylcyclohexanecarboxamide is 1-[2-(2-methoxyethoxy)ethyl]-4-methyl-1,4-dihydropyridine 2,4-dicarboxylic acid methyl ester. This compound inhibits insulin release from the pancreas and stimulates glucagon release from the alpha cells in the pancreas. These effects lead to an increase in blood glucose levels.

Versatile small molecule scaffold

2-(Naphthalen-1-yl)ethanethioamide is a phytohormone that belongs to the class of ethylene. It is involved in the regulation of many processes, including apical dominance, peduncle elongation, leaf senescence, and fruit ripening. 2-(Naphthalen-1-yl)ethanethioamide is an active form of ethylene that binds to the receptor protein ETR1. This binding stimulates the synthesis of proteins that regulate these processes. It has been shown to be effective in treating flowers with inflorescence stems and fruits with peduncles. The transformation process may involve hydrocarbon molecules with long aliphatic chains.

5-(Trifluoromethyl)-2-furaldehyde is a trifluoroacetate that is used for the trifluoromethylation of organic compounds. It can be used to produce 5,5-difluoro-2-pentanol, which is an organic solvent. The reaction proceeds through an electrophilic substitution mechanism.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(4-Chlorophenyl)-1H-imidazole-2(3H)-thione is a crystalline solid that belongs to the class of imidazoles. It has been synthesized by reacting 1,2-dibromoethane with sodium methoxide in methanol. The compound was found to have a melting point of about 183°C and a molecular weight of 212.06 g/mol. This compound has been shown to interact with methanol, methoxide, and ethoxy groups. Crystallization occurs when the substance is heated to about 183°C in vacuum and then cooled slowly.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Benzyloxane-2,6-dione is a methyl ester that has been optimized for pharmacokinetic properties. It is an amide with a catalytic activity and has been shown to bind to phospholipids. This compound has been screened in high-throughput screening tests and has been validated by binding to brain tissue. The pharmacological effects of 4-Benzyloxane-2,6-dione have not yet been elucidated but it is believed that the compound may be able to inhibit the production of beta amyloid peptides in the brain, which are thought to play a role in Alzheimer's disease.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-bromo-2-methylpent-1-ene is an organic compound that belongs to the group of isopentenyl compounds. It is a synthetic compound that has been shown to be effective as an antimicrobial agent. 5-bromo-2-methylpent-1-ene has a copper complex which binds to the copper and diphosphate groups in bacterial DNA, preventing replication and transcription. This drug also inhibits the synthesis of proteins by binding to ribosomes, thereby inhibiting protein synthesis. The antimicrobial activity of 5-bromo-2-methylpent-1e is due to its ability to inhibit RNA synthesis and DNA synthesis in bacteria.

Versatile small molecule scaffold

Versatile small molecule scaffold

Nitrophenols, such as 5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ol (NPO), are a class of drugs that bind to the c1-6 alkyl receptor. This binding causes receptor desensitization and leads to the inhibition of the release of neurotransmitters such as acetylcholine, histamine, and serotonin. NPO is an excipient in some pharmaceuticals and may also be used for treatment of high blood pressure or damaged heart tissue. The carboxylic acid group on NPO can react with sodium ions to form a salt called sodium nitrophenolate. The residue from this reaction can be removed by adding a cationic polymer before use.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold