Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Bromo-3-iodonitrobenzene is a pyrrole derivative that yields 4-bromo-3-iodobenzene upon treatment with palladium. It is a precursor to other products, such as 3-iodo-4-(pyrrolidinomethyl)benzoic acid and 4-(pyrrolidinomethyl)benzoic acid. This compound can be used in the synthesis of biomolecules, such as nucleosides, nucleotides, amino acids, peptides, and proteins. The synthesis of this compound involves deuterium exchange between the bromine and the hydrogen on the nitrogen atom. For example, if 4-bromo-3-iodonitrobenzene reacts with sodium methoxide in methanol it will produce 4-(methylamino)-3-(iodomethyl)aniline hydrochloride. The reaction yield of this

Versatile small molecule scaffold

4-(4-Methylphenyl)-3-thiosemicarbazide is a carbonyl compound. It has been shown to be an inhibitor of acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine, which is involved in muscle contraction. This inhibition causes paralysis and death in insects. 4-(4-Methylphenyl)-3-thiosemicarbazide has also been shown to be active against gram-negative bacteria. The structure of this molecule was determined by its vibrational spectra and multinuclear NMR data. 4-(4-Methylphenyl)-3-thiosemicarbazide stabilizes the dihedral angle between two nitrogen atoms, which are necessary for formation rate.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(3-Methylfuran-2-yl)ethan-1-one is a heterocyclic compound that can be found in the leaves and tubercles of Bignoniaceae plants. It is structurally related to an oxygen heterocycle, which is a class of organic compounds with oxygen in their molecular structures. 1-(3-Methylfuran-2-yl)ethan-1-one has been isolated from the leaves of Blechnum pennaefolium and the tubers of Tuberculosa leontopodioides by alkaline hydrolysis. It has shown antimicrobial activity against Gram positive bacteria. The diacetate form was isolated from the leaves of Bignonia colemanii and shown to have antiviral properties. Formylation reactions are also possible with this compound, as it has been shown to react with sodium methoxide or dimethyl sulfoxide to produce formaldehyde and methanal respectively.

2-Ethylbut-2-enedioic acid is an aliphatic hydrocarbon that has a particle size of about 1 micron. It is a monocarboxylic acid that is commonly used as a precursor to the synthesis of polycarboxylic acids. 2-Ethylbut-2-enedioic acid can be activated by reacting with tertiary amines or phosphines and subsequently reacting with alcohols or thiols. The latter reaction will produce esters or ethers, respectively. This compound has been shown to have antiinflammatory effects in models of autoimmune diseases, such as arthritis and colitis, which are due to its ability to inhibit the production of proinflammatory cytokines.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Amino-4-bromobenzamide is a ring-opening reaction system that is used in the synthesis of isatins. It has been shown to be an efficient and rapid method for the synthesis of this class of heterocyclic compounds. The oxidative nature of this reaction makes it useful for generating reactive intermediates, which can be used for further transformations.

Versatile small molecule scaffold

Versatile small molecule scaffold

1,2-Thiazinane-1,1-dione is a short-chain alkylating agent that has been shown to have neuropathic and inflammatory pain relief. It binds to a number of halides and inhibits their action, including the inhibition of angiotensin I-converting enzyme (ACE), which is an antihypertensive agent. 1,2-Thiazinane-1,1-dione also inhibits the production of epoxides in c1-4 alkyl groups. This drug also has antibacterial properties and can be used as a chemical probe for ligand binding studies.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N-(2-Hydroxy-2-methylpropyl)acetamide (HMPA) is a molecule inhibitor that inhibits the activity of inflammatory bowel disease (IBD)-associated kinases. HMPA is a member of a family of molecules that are inhibitors of IBD-associated kinases, which may be useful for the treatment of IBD. HMPA has shown in vitro inhibition against two kinases, JNK1 and p38 MAPK, which are both important mediators in the progression of IBD. This drug may be used to inhibit inflammation in the digestive tract by blocking these inflammatory pathways.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Methylphthalic Acid is a chemical that is used in the production of polyvinyl chloride. It is produced by the dioxygenation of phthalic anhydride and methanol, which produces 3-methylphthalic acid as well as 1,1-dichloroethane. The chemical can be used as a surfactant in polyvinyl chloride and styrene production processes. 3-Methylphthalic Acid has been shown to have adverse health effects on laboratory animals, including polyvinyl chloride workers who are exposed to it for prolonged periods of time. The chemical can cause irritation and corrosion to skin and eyes, as well as damage to the liver and kidneys.