Building Blocks

Versatile small molecule scaffold

2-[Benzyl(methyl)ao]propanoic acid is a glycine analogue that has been synthesized and characterized. It is an α-amino acid with the chemical formula C5H11NO2. The molecule has a chiral carbon atom at the center of the propanoic acid group and contains two asymmetric carbon atoms on the benzene ring, which enable it to exist in two stereoisomers. The compound has been shown to exhibit interligand interactions with copper as well as stereoselectivity in its interactions with l-amino acids. 2-[Benzyl(methyl)ao]propanoic acid also exhibits dichroism spectra, which are unique to these types of molecules.

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Chloro-4-isocyanobenzene (1CI) is an organic compound that has been used as a chemical probe for the detection of amines and other molecules on metal surfaces. The frequency shift in Raman spectra, which is observed after the addition of 1CI to the metal surface, is used to detect amines. 1CI has also been shown to be a potent inhibitor of mitochondrial function. This molecule binds to nucleophilic sites on metal surfaces and forms covalent bonds with them, leading to a high degree of inhibition.
1CI can be synthesized in three steps from commercially available starting materials and is relatively easy to purify.

2-[3-(Propan-2-yl)phenoxy]acetic acid is a chemical compound that is used as an additive in benzene, and is a phytotoxic chemical. It prevents the formation of chlorophyll by blocking electron transport and inhibiting photosynthesis. 2-[3-(Propan-2-yl)phenoxy]acetic acid is used to induce callus tissue from lettuce, radish, and other plants. This compound also inhibits the growth of various bacteria including Escherichia coli and Pseudomonas aeruginosa.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,4-Dibromo-6-nitroaniline is a nitro compound that has been used in the production of dyes. It is also used as a component in the synthesis of other organic compounds. 2,4-Dibromo-6-nitroaniline can be produced by electrolysis of an acid solution containing radical cations and benzene. The radical cations are formed by proton transfer from the acid to the benzene, followed by electron transfer from benzene to the electrode. This process results in the formation of nitro groups on the benzene ring, which undergoes oxidation to form 2,4-dibromo-6-nitroaniline. The cyclic voltammetry shows that this process occurs via two pathways: one with a fast rate and one with a slow rate. The mechanism for this reaction is not yet known.

2-Phenyl-1,3,4-oxadiazole is a 2-phenyloxazole with an oxygen atom at the 1 position. It is a white crystalline solid that is soluble in water and has antibacterial properties. This chemical can be used as a catalyst for the synthesis of organic compounds. 2-Phenyl-1,3,4-oxadiazole reacts with nitro groups to form oxime derivatives and has been shown to inhibit the growth of fungi such as Candida albicans and Aspergillus niger. 2-Phenyl-1,3,4-oxadiazole can also be used as an antifungal agent against Trichophyton rubrum.
2-Phenyl-1,3,4-oxadiazole may be synthesized by reacting phenol with acetone in the presence of nitric acid or sulfuric acid. The structural formula for this compound is

Versatile small molecule scaffold

Tris(hydroxymethyl)propane is a diphenyl ether that has been shown to have an electrochemical impedance spectroscopy (EIS) spectrum in the human serum that is similar to those of other known antioxidants. Tris(hydroxymethyl)propane has been shown to protect against light-induced damage in human skin cells, and it also has radiation protective effects. Tris(hydroxymethyl)propane has also been shown to interact with trimethylolpropane, which is another antioxidant, and this interaction may affect the effectiveness of each agent. Tris(hydroxymethyl)propane inhibits lipid peroxidation by inhibiting the oxidation of fatty acids and hydroxyl groups on proteins.

Versatile small molecule scaffold

3-(1H-Tetrazol-5-yl)phenol is a coordination compound that belongs to the class of nitrates. It has magnetic properties and can be found in a number of architectures, such as frameworks and solid-state structures. 3-(1H-Tetrazol-5-yl)phenol can be synthesized in the form of single crystals using a combination of a nitrate salt, ammonium chloride, and sulfuric acid. 3-(1H-Tetrazol-5-yl)phenol has been used as an analytical tool for elemental analysis. This compound's luminescence properties have been studied extensively, with the use of different spectra such as UV/Vis absorption spectroscopy or emission spectroscopy.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Chloro-4-iodoaniline is an activated, synthetic chemical that is used in the preparation of a variety of chemicals. 3-Chloro-4-iodoaniline can be prepared by the reaction of chloroacetic acid with nitrobenzene and hydrochloric acid. The compound may be purified by vacuum filtration and recrystallization from water. It is also a precursor to other chemicals that are used in the production of polyhalogenated aromatic compounds. 3-Chloro-4-iodoaniline has been found to react with amines and form the corresponding amides, which may be useful for chemical synthesis.

Versatile small molecule scaffold