Building Blocks

<p>1,4-Dimethyl 2-hydroxy-2-methylbutanedioate is an allylating agent that modifies the amino acid lysine residues in proteins. It has been shown to be effective in the treatment of skin lesions caused by Staphylococcus aureus and other bacteria because it inhibits bacterial growth through an antimicrobial effect. 1,4-Dimethyl 2-hydroxy-2-methylbutanedioate also has been used as a precursor for the synthesis of vitamin D3. This compound is metabolized in mammalian cells to form cysteamine, which is further converted to S-(1,4-dimethylpentadienoyl)cysteamine (DMPE). The resulting product can be used as a functional group on collagen or malic acid. 1,4-Dimethyl 2-hydroxy-2-methylbutanedioate also is used for modifications of mucocutaneous tissues such as skin and oral muc</p>

<p>3-Chloro-1,2,4-benzotriazine is an organic compound that is used as an anti-cancer agent. It is a cytotoxin that inhibits the growth of cells by binding to DNA. The Suzuki reaction was used to synthesize this compound in high yields. 3-Chloro-1,2,4-benzotriazine has potential anti-cancer activity and can be used in conjunction with other cytotoxic agents to treat cancer. This drug has been shown to have cytotoxic effects on tumor cells by inhibiting DNA synthesis and cell division.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tert-butyl (2S)-2-aminohexanoate is an intermediate that is used in the synthesis of glycine by the reaction of benzyl bromide and tert-butyl amine. The stereospecifically incorporated tert-butyl group has a high degree of enantioselectivity, which makes this intermediate useful in the synthesis of glycine. Tert-butyl (2S)-2-aminohexanoate can be synthesized using lithium diisopropylamide and a tertiary amine as an alkylating agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-4H,5H-naphtho[2,1-b]thiophene-1-carbonitrile is a dihydronaphthalene compound that has been shown to be active against influenza viruses. It inhibits the virus by binding to the pyrimidine ring of the virus's RNA polymerase. This inhibits viral replication and reduces plaque formation. 2-Amino-4H,5H-naphtho[2,1-b]thiophene-1-carbonitrile has antiviral activity against influenza A and is effective in inhibiting h5n1 virus replication.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 5-oxo-3-thioxo-2H-1,2,4-triazine-6-carboxylate is an acid ethyl ester of the triazine compound ethyl 3,5,6,7,8,-tetrahydro-2H-[1]benzothiopyran-2,4(3H)-dione. It has been shown to inhibit bacterial growth by binding to the enzyme ribonucleotide reductase.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole is a recombinant protein that binds to the ribosomal protein L11. It has been shown to inhibit the biosynthesis of the bacterial cell wall and therefore inhibit replication of the bacterial genome. 3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole also inhibits the synthesis of proteins essential for cell division. This compound has been shown to bind to ribosomes in both prokaryotic and eukaryotic cells. It may have potential as an inhibitor of cancerous cells because it inhibits protein synthesis in mammalian cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>The synthesis of (2-bromophenyl)(phenyl)methanol is accomplished by the reaction of an aldehyde with bromine followed by an alkylation with magnesium. The product is obtained as a racemic mixture of enantiomers with a chiral center, which can be resolved by fractional crystallization or other separation methods. This method has been shown to be efficient for the synthesis of alcohols and carbinols, and stereogenic reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.</p>