Building Blocks

2-(Piperidin-4-yl)ethan-1-amine is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzyme pancreatic lipase. This inhibition of lipases leads to the decrease in triglycerides and phospholipids in the blood, which prevents inflammation. 2-(Piperidin-4-yl)ethan-1-amine has been shown to have antibacterial and antifungal properties. It has been used for the treatment of infections caused by Mycobacteria sp., including Mycobacterium tuberculosis, M. avium complex, and M. kansasii. It also has been used for the treatment of orlistat induced side effects such as steatorrhea and diarrhea. The use of this drug is limited because it can cause liver toxicity or gastrointestinal ulceration at high doses.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Bromocyclohexane-1-carbonitrile (1BCC) is an orthogonal alkylation agent that can react with a wide variety of functionalized organic halides. It reacts with the carbon atom in the organic halide, forming a new carbon-carbon bond. This reaction is highly selective and does not require any protecting groups or activation by copper. 1BCC also has high activity with nitroalkanes, which makes it a useful reagent for synthesizing diamines. 1BCC can be used as an efficient synthetic method for aromatic and nonaromatic diamines.

Versatile small molecule scaffold

Versatile small molecule scaffold

N-(1,3,4-Thiadiazolyl)nicotinamide is an intracellular drug that inhibits the release of a growth factor, which may be involved in the development of migraine. It has been shown to inhibit the activity of the enzyme VEGF and reduces infarction volume in rats. N-(1,3,4-Thiadiazolyl)nicotinamide also has a neuroprotective effect by reducing reactive astrocytes and inhibiting fibrillary acidic protein expression in the cerebral cortex of rats. This drug is osmotically active and can induce neuronal damage due to brain swelling. N-(1,3,4-Thiadiazolyl)nicotinamide is also used as a stain for neurons in histological studies.

Versatile small molecule scaffold

Versatile small molecule scaffold

2,4,6-Trichlorobenzenesulfonyl chloride is a sulfonylating agent that is used to treat metabolic disorders and iron metabolism. It is also used as an x-ray contrast agent for the detection of certain types of cancers. In addition, 2,4,6-trichlorobenzenesulfonyl chloride has been shown to have anti-inflammatory properties in chronic inflammatory diseases. This drug can be used to inhibit the synthesis of hepcidin by blocking the catalytic activity of ferrochelatase. 2,4,6-trichlorobenzenesulfonyl chloride may also be able to reduce inflammation by its ability to form reactive chlorides that react with alcohols and aldehydes. This can lead to deficiency symptoms such as chronic inflammatory disease or alcohol intolerance.

5-(4-Hydroxyphenyl) tetrazole is a hydrophobic ligand that has been shown to bind to cisplatin and therefore may have potential use in cancer therapy. It has also been used as an anti-inflammatory agent with the potential to inhibit prostaglandin synthesis. 5-(4-Hydroxyphenyl) tetrazole binds to hydrogen peroxide, which is a strong oxidizing agent and produces reactive oxygen species (ROS). ROS can cause DNA damage and lead to cell death by apoptosis or necrosis. 5-(4-Hydroxyphenyl) tetrazole reacts with cisplatin, which is a chemotherapeutic agent that is used in the treatment of various types of cancer. Cisplatin binds to DNA and prevents replication, leading to cell death. Hydrophobic ligands such as 5-(4-Hydroxyphenyl) tetrazole are able to bind more tightly than other ligands because

Versatile small molecule scaffold

Versatile small molecule scaffold