Building Blocks

Versatile small molecule scaffold

BG45 is a mutant strain of the bacterium Lactobacillus plantarum that has been modified to express a protein that inhibits the growth of tumor cells. The BG45 bacterium is capable of inducing an inhibitory effect on cancer cell growth in vitro and in vivo. This inhibitory effect is due to the immunomodulatory effects of the bacterium, which are mediated by suppressing genes that are involved in immune response and lipid metabolism. Furthermore, BG45 has significant cytotoxicity when cultured with human cancer cells and suppressed tumor growth in murine xenografts. This bacterium also has lysine residues that can be used as an indicator for identifying nutrient-poor environments such as microenvironments, suggesting that it may have potential use as a probiotic for patients with gastrointestinal disorders. In vitro assays have shown that BG45 produces fatty acids, which may be responsible for its activity against tumors.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Iodo-2-methoxypyrimidine is an enantioenriched, modular, polyfunctionalized, derivatized molecule that has been shown to be both antiproliferative and selective. It is synthesized in a two step reaction from acetate and 2-iodo-5-methoxypyridine via the use of a coupling agent, such as HATU. The synthesis proceeds with an arylation followed by a decarboxylative coupling reaction. This synthetic method produces 5-iodo-2-methoxypyrimidine in high yields with excellent enantioselectivity.

2,3-Dihydro-5(1H)-indolizinone (NU-120) is a quinoid compound that has been shown to have anti-oxidant and anti-inflammatory properties. The prodrug form of NU-120 is converted to the active n-oxide form in vivo by the enzyme cytochrome P450. This conversion takes place at an efficient rate with oral absorption between 0.2% and 2%. The drug has a crystalline structure and solvates readily in water.

2-[Benzyl(methyl)ao]propanoic acid is a glycine analogue that has been synthesized and characterized. It is an α-amino acid with the chemical formula C5H11NO2. The molecule has a chiral carbon atom at the center of the propanoic acid group and contains two asymmetric carbon atoms on the benzene ring, which enable it to exist in two stereoisomers. The compound has been shown to exhibit interligand interactions with copper as well as stereoselectivity in its interactions with l-amino acids. 2-[Benzyl(methyl)ao]propanoic acid also exhibits dichroism spectra, which are unique to these types of molecules.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold