Building Blocks

1,4-Butanedisulfonic acid disodium salt is a calcium chelator that is used in the treatment of hypercalcemia and chronic renal failure. It binds to the calcium ion and prevents it from binding to bone, thus lowering the level of calcium in the blood. This drug has been shown to be effective against hepatitis when given orally and also has been shown to be safe for people with liver diseases. 1,4-Butanedisulfonic acid disodium salt also has transport properties and can be administered orally or intravenously.

<p>6-Bromo-2-(4-bromophenyl)-indole is a fine chemical with CAS No. 28718-96-9 that can be used as a versatile building block for the synthesis of complex compounds, useful scaffold for research chemicals, and reaction component for speciality chemicals. This compound has high quality and is a reagent in the synthesis of other compounds.</p>

<p>4-Hydroxymethylpiperidine hydrochloride is a fine chemical that has been used as a versatile building block for the synthesis of complex compounds. It is available for sale as a research chemical, and can be used as an intermediate or reagent in the synthesis of specialty chemicals. This compound is useful in the production of pharmaceuticals, agrochemicals, dyes, and fragrances. 4-Hydroxymethylpiperidine hydrochloride has been found to be useful in the manufacture of high-quality products.</p>

<p>6-Hydroxyquinoline-(1H)-2-one is an organic compound that has been shown to inhibit the uptake of carbostyril by bacterial cells. This inhibition causes increased uptake of xanthurenic acid and anthranilic acid, which are two compounds that are found in wastewater treatment. 6-Hydroxyquinoline-(1H)-2-one may be a potential anticancer agent, as it inhibits the growth of astroglia cells and bladder cancer cells. It also reacts with acylation reactions to form quinolinic acid, which has been shown to have anticancer effects.</p>

<p>Starting reagent for synthesis of P3HT; nanofibres used for preparation of OPTs</p>

<p>DL-Cysteine is a naturally occurring amino acid that is found in human cells and other living organisms. It has been shown to have antioxidant properties. DL-Cysteine has also been shown to be a cofactor for enzymes that synthesize proteins, DNA, and RNA. DL-Cysteine may also have the ability to regulate cellular iron homeostasis through its effects on the expression of genes that play a role in this process. This amino acid can also inhibit molecules that are involved in protein oxidation and provide biochemical properties for use as research tools.</p>

<p>2,4-Dihydroxybenzoic acid (2,4-DB) is a metabolite of salicylic acid. It is used as an intermediate in the production of various drugs and dyes. 2,4-DB has been shown to be effective against hepatic steatosis induced by hydrogen fluoride in mice. This drug also inhibits mitochondrial membrane potential and DNA binding activity in human serum. 2,4-DB can bind to the α subunit of mitochondrial ATPase and act as a competitive inhibitor for p-hydroxybenzoic acid which is essential for the activation of this enzyme. The x-ray diffraction data from crystalline 2,4-DB shows that this compound binds to dna with coordination geometry that resembles that of salicylic acid. The kinetic studies have shown that 2,4-DB reacts noncompetitively with nonsteroidal anti-inflammatory drugs (NSAIDs).</p>

<p>3,5-Dichlorosalicylic acid is a proton donor that is used to inhibit the 5-nitrosalicylic acid chain reaction. It has a high binding constant with the chlorine atom and can be used as a competitive inhibitor for the binding of 5-nitrosalicylic acid to its target enzyme. 3,5-Dichlorosalicylic acid inhibits the polymerase chain reaction by binding to DNA. This chemical also has biological properties that are similar to those of salicylic acid, including anti-inflammatory activities. 3,5-Dichlorosalicylic acid is not an effective anti-cancer agent because it does not form intramolecular hydrogen bonds or hydrogen bond interactions with DNA bases.</p>

<p>L-Homoglutamine is a non-essential amino acid that is an important part of the urea cycle. It also plays a role in protein synthesis, as well as in transfer reactions, such as the conversion of ammonia to urea. L-Homoglutamine has been shown to be an inhibitor of binding to collagenase, which may have therapeutic applications for diseases such as rheumatoid arthritis. This amino acid has been used in enzyme preparations and has been found to have biological properties that are similar to those of other carbonyl amino acids (e.g., L-glutamic acid).</p>

<p>2-Bromo-1H-imidazole is an environmental pollutant that has been detected in the atmosphere, water, and soil. It is used as a pesticide and has been found to be an impurity in biphenyl. 2-Bromo-1H-imidazole can be used as a substrate for the Suzuki coupling reaction or as a starting material for the synthesis of imidazole derivatives. The compound spontaneously fragments under acidic conditions to form nitric acid and hydrogen bromide. 2-Bromo-1H-imidazole has been shown to inhibit hepatitis C virus (HCV) replication and induce cancer cell apoptosis in vitro.<br>2-Bromo-1H-imidazole is also known to cause DNA fragmentation in cells through oxidation by reactive oxygen species or through spontaneous decomposition of the molecule into acid, bromine radicals, and ammonia.</p>

<p>4-Bromo-3-nitroacetophenone is a potent anticancer agent that has been shown to inhibit cancer cell growth by inhibiting the activity of dehydrogenase enzymes. It has been shown to be active against g1 phase cells, which are cells in the phase of cell cycle before mitosis. 4-Bromo-3-nitroacetophenone also has anti-inflammatory effects and can cross the blood brain barrier due to its hydrogen bond formation. This drug is selectively toxic to cancer cells while sparing healthy tissues and has been shown to be effective in treating inflammatory diseases, such as arthritis, by decreasing the production of proinflammatory cytokines.</p>

<p>2-Methyl-5-nitroimidazole-1-propanol (2MI) is a matrix effect correction reagent that can be used to reconstitute the original concentrations of drugs in plasma and urine samples. It is also used for sample preparation, validation and quality control. 2MI has been shown to bind with cervical cancer cells, which may be due to its ability to bind with drug receptors on the surface of these cells. A liquid chromatography-mass spectrometry (LC-MS/MS) method was developed to measure 2MI in plasma and urine samples. The method was validated using test samples and showed good agreement with the target concentration.</p>