Building Blocks

<p>Versatile small molecule scaffold</p>

<p>5-Amino-1H-pyrazole-3,4-dicarbonitrile is a nucleophilic compound that is used for the synthesis of other compounds. It reacts with anilines in the presence of silver ions and hydrogen chloride to form 5-aminopyrazoles. This reaction can also be reversed, forming pyrazoles from 5-aminopyrazoles. The product has been shown to have antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA), as well as being able to inhibit the growth of Mycobacterium tuberculosis and Mycobacterium avium complex. The product also has an effect on the central nervous system, producing sleepiness and sedation. These effects are due to its ability to inhibit brain monoamine oxidase (MAO) enzymes and block postsynaptic receptors in the central nervous system.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-oxo-cyclohex-1-enecarboxylate is a catalytic and enantioselective dienophile that has been synthesized for use in the synthesis of carboxylic esters. It can be used as a switchable skeleton, which allows for both enantiomeric forms to be produced from the same starting material, thereby increasing efficiency. Methyl 3-oxo-cyclohex-1-enecarboxylate is also useful in affinity chromatography because it binds with high affinity to carboxylic acids. The mechanism of this reaction involves an E2 elimination reaction followed by a 1,2 addition of water to form an enolate intermediate. This intermediate then reacts with the dienophile to form the desired product.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 4-pyridylacetate is an organic compound that is soluble in solvents. It has a functional group that consists of a covalent bond and a hydrogen atom. This compound can be used as a colloid, assembled, or solvents and it can be used for recycling catalytic functionalities. Multilayer dendrimers are made from ethyl 4-pyridylacetate and have been shown to have photocatalytic properties. The multilayered structure of the dendrimers provides the opportunity for the synthesis of scalable materials with desired functions.</p>

<p>Versatile small molecule scaffold</p>

<p>The chemical compound 2-(Pyridin-2-ylmethoxy)benzaldehyde is a titration indicator that changes color from yellow to red as the pH increases. The anion of this compound is spirolactam, which is an endogenous substance. The sensor yields fluorescence when excited with light in the near infrared region at 710 nm. This emission can be enhanced by nitrosohydroxylamine, which is a fluorophore. When excited in the visible region of the spectrum, 2-(Pyridin-2-ylmethoxy)benzaldehyde emits red light. It has been shown to have biomolecular applications, including quantum yields that are important for understanding how enzymes function in living systems.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Oxo-2,3-dihydropyridazine-4-carboxylic acid (3ODPCA) is a molecule that is used to treat endometriosis. It has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit the production of prostaglandin E2 and nitric oxide. 3ODPCA binds to DNA with high affinity and interferes with transcription by inhibiting the binding of RNA polymerase II and III, preventing the synthesis of mRNA. This drug also inhibits protein synthesis in cells by inhibiting ribosome translocation on mRNA. 3ODPCA has been shown to be an effective treatment for endometriosis in rats and mice models.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Bromo-2-methylquinoline is a molecule that has been synthesized by the reaction of 2-methylquinoline with trifluoroacetic acid. The acid group of 5-bromo-2-methylquinoline is an important component in the synthesis of various heterocycles, and can be used to form compounds with a variety of different functional groups. 5-Bromo-2-methylquinoline is also effective in catalyzing reactions that involve carbonylation, vinylation, dehalogenation, and alkylhydroxylamine formation. This molecule has been shown to be useful for the synthesis of many organic compounds, including benzene derivatives.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1H-Pyrrolo[2,3-c]pyridin-2(3H)-one (1) is a synthetic compound that has been extracted from coal tar. It is the product of nitro reduction and transfer hydrogenation. 1H-Pyrrolo[2,3-c]pyridin-2(3H)-one is an unactivated heteroaromatic base with a phenyl ring and a pyridine ring. This compound has been used in experimental studies as a biomolecular research tool and medicinally as an oxindole. The synthesis of this compound requires two cyclization steps, one of which can be achieved by hydrogenation.</p>

<p>1-Cyclohexylethylamine is a small molecule that belongs to the group of amines. It has an enantiopure structure, meaning that it has only one type of chiral centre. 1-Cyclohexylethylamine is a hydrogen bond donor and can form hydrogen bonds with the O atom in the hydroxyl group of citric acid. It has been shown to have anticancer activity against cancer cells in vitro and in vivo. The biological properties of this compound are incompletely understood due to its lack of study. 1-Cyclohexylethylamine crystallizes as a racemic mixture, which means that it contains both enantiomers. Crystallography studies show that the two enantiomers have different physical properties, including melting point and density.</p>