Building Blocks

<p>2-Bromo-3-pyridinemethanol is a heteroaryl compound that contains a pyridine ring. It is synthesized by the lithiation of 2-bromopyridine followed by intramolecular bromination with 3-bromopyridinemethanol. The methodologies for this synthesis are similar to those used in the synthesis of quinolines and pyridines. Lithiation of 2-bromopyridine at low temperature (0°C) led to the formation of 2,6-dibromopyridine, which was then reacted with 3-bromopyridinemethanol in a sequence similar to that described for the synthesis of quinoline and pyridine. This reaction yielded 2,6-dibromo-3-(2'-pyridinyl)-N,N'-dimethylethanamine. The desired product was obtained after cyclization with potassium tert</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-5-(bromomethyl)thiazole is an industrial chemical that belongs to the tribromide class of compounds. It is used as a solvent in organic reactions and can be prepared by reacting sodium borohydride with 2-bromothiazole. The preparation process includes recrystallization from acetonitrile and dihedral rotation with potassium carbonate and phthalimide.<br>2-Bromo-5-(bromomethyl)thiazole has been shown to react with fluoride ions to form a borohydride ion, which is then able to abstract a hydrogen atom from a molecule of water to produce hydrogen gas.</p>

<p>2-bromo-1,3-thiazol-5-yl)methanamine is a ring system that contains a phthalimide and thiazole. It has a planar molecular geometry. The methoxy group is located on the left side of the molecule, which creates a dihedral angle of about 60°. The two bromine atoms are on opposite sides of the molecule and are separated by 2.6 Å. This ring system reacts readily with nucleophiles to form covalent bonds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Hydroxy-3-phenylpentanamide is a chiral molecule that has been found to produce neurotoxic effects in rats. 3-Hydroxy-3-phenylpentanamide binds to the benzodiazepine binding site on the GABA receptor and produces a neurotoxic effect. The neurotoxicity of this drug was studied using x-ray crystallography and it was found that 3-hydroxy-3-phenylpentanamide binds with high affinity to the gamma amino butyric acid (GABA) receptor, which causes an increase in chloride ion flow into the neuron and can lead to death of the neuron. This compound also has a halogen substituent at C3, which may be responsible for its toxicity. 3-Hydroxy-3-phenylpentanamide is an enantiomer that is not present in nature and is produced synthetically by reacting phenylacetonitrile with hydroxylamine followed by chlorination. It has</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-1H-indole-3-carbonitrile is a nucleoside analog used as a precursor for the synthesis of other biologically active compounds. 2-Amino-1H-indole-3-carbonitrile has been shown to be capable of forming hydrogen bonds with nucleic acid bases, which can lead to changes in conformation and chain length. This leads to changes in the spectra of these compounds, allowing them to be identified.<br>2AICC is prepared from indolium salt and carbon tetrachloride by reaction with ammonia gas. The reaction takes place in an ice bath with stirring and produces a white solid that can be purified by recrystallization or column chromatography.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>