Building Blocks

Versatile small molecule scaffold

2-Methylpropane-1-sulfonyl chloride is a ligand that binds to anilinoquinoline derivatives, such as the triazoles. It is also used in pharmaceuticals and as an antibacterial agent. 2-Methylpropane-1-sulfonyl chloride has been shown to inhibit Alzheimer's disease by preventing the accumulation of beta amyloid protein. This drug also inhibits bacterial growth by binding to the hydroxyl group on the outside of thiols, which are sulfur-containing compounds found in bacteria. 2-Methylpropane-1-sulfonyl chloride is structurally similar to pyridazine, a heterocyclic compound that acts as an inhibitor of DNA synthesis and protein synthesis in bacteria.

1-Hydroxy-benzocyclobutene is a molecule that has been isolated from the marine sponge, Tethya crypta. It is a thioether that has been shown to inhibit the growth of Clostridium perfringens. This effect may be due to 1-hydroxy-benzocyclobutene's ability to bind primary amines in the bacterial cell wall and prevent the formation of an enzyme-inhibitor complex with the enzyme cell wall synthesis required for cell wall biosynthesis. 1-Hydroxy-benzocyclobutene also has been shown to have antioxidant properties, which may be due to its ability to absorb uv radiation and form reactive oxygen species (ROS).

4-Bromo-2,5-dimethoxybenzoic acid (BDMA) is a chemical compound that has been used as an intermediate in the synthesis of pharmaceuticals. It is also used as a precursor for the synthesis of other compounds. BDMA has been shown to be toxic to both humans and monkeys, with toxic effects including convulsions, dyspnea, mydriasis, vomiting, and coma. The toxicological profile is not well understood because it has not been extensively studied. Studies have shown that BDMA undergoes oxidative deamination to form 4-bromo-2,5-dimethoxyamphetamine (DOB), which can cause hallucinations and nausea when ingested.