Building Blocks

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-2-oxocyclohexanecarboxylate is a diterpene alkaloid that has been prepared by the Friedel-Crafts reaction of ethyl bromoacetate and cyclohexane. The product is an intramolecular arylation, which means that the two carbons in the ring are bonded to each other. This type of reaction usually produces a group specific functional group, such as an acid chloride or ester, but in this case it produces an alcohol. 3-Bromo-2-oxocyclohexanecarboxylate is used as a precursor for silver salts which are used to make photographic film.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Methyl-2-(trichloroacetyl)imidazole is a small molecule that is synthesized for the treatment of cancer. It interacts with dna and inhibits its function by binding to the minor groove in DNA, which causes conformational changes. 1-Methyl-2-(trichloroacetyl)imidazole has been shown to be effective against cancer cells that are resistant to other anticancer compounds. The molecular target for this compound is not fully understood, but it may work by inhibiting DNA synthesis or by inducing apoptosis. 1-Methyl-2-(trichloroacetyl)imidazole has shown some activity against leukemia and colon cancer cell lines in vitro and in vivo.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(3-Pyridyl)-2-thiourea is an organic compound that belongs to the thiourea functional group. It is a white crystalline solid that has orthorhombic symmetry. 1-(3-Pyridyl)-2-thiourea has a protonated nitrogen atom on its pyridine ring, which gives it a positive charge. This functional group interacts with other molecules due to the presence of lone electron pairs on the nitrogen atom and the carbonyl oxygen atom. Crystal x-ray diffraction studies have shown that 1-(3-Pyridyl)-2-thiourea crystallizes in the group p2 space group and is oriented along [001]. The ligand coordinates are nitrate and solvent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine is a group P2 molecule that diffracts well with x-rays. The compound has a molecular weight of 270.27 g/mol and the chemical formula is C12H11N5. 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine is soluble in acetonitrile but insoluble in water. The compound is stable at room temperature but will evaporate when heated to higher temperatures. 3,6bis(3,5dimethyl 1Hpyrazol 1yl) 1 2 4 5 tetrazine can be found in biochemical reactions as a nucleophile or can act as an inhibitor to enzymes such as cytochrome c oxidase or ATP synthase</p>