Building Blocks

Versatile small molecule scaffold

3,5-Dimethyldodecanoic acid is a fatty acid with high densities that has potential use in pest control. It is synthesized by the enantioselective addition of malonic acid to oleic acid and it has been shown to be a potent attractant for the target pest. The stereoisomers of 3,5-dimethyldodecanoic acid are active against different pests, which may be due to their ability to bind to specific receptors on the insect's antennae. This compound could also be used as a chromatographic stationary phase for separating stereoisomers.

Versatile small molecule scaffold

2,3-Dihydroxypropyl 4-hydroxybenzoate is a hydrolysis product of the parabens and is an intermediate in the synthesis of 4-hydroxybenzoic acid. The transesterification reaction involved in this process requires glycerol as a byproduct. The chemical stability of 2,3-Dihydroxypropyl 4-hydroxybenzoate has been evaluated using spectroscopy to determine if it can be used as a medicinal preparation. The hydrolysis of this compound occurs at pH values between 6 and 8, with a half-life of 1.2 hours at pH 7.5 and 50°C. This compound is stable when heated to 100°C for 10 minutes or when subjected to light for 3 hours. It also shows no mutagenicity under conditions that induce gene mutation in bacteria (Ames test).

4-[(1S)-1-Hydroxyethyl]phenol is a compound that is metabolized to 4-hydroxymandelic acid and 4-hydroxyphenylglycine by microbial metabolism. This chemical has been shown to be a substrate for the enzyme dehydrogenase, which may be flavoprotein or polyacrylamide gel. The regiospecificity of the reaction was determined through enantiomer analysis of vanillyl alcohol as the product. Enantiomers were separated using a short-chain alkyl ester, although other solvents such as acetone may be used. The eugenol isomers are present in the reaction products and they can be determined by gas chromatography or liquid chromatography with a mass spectrometer detector. 4-[(1S)-1-Hydroxyethyl]phenol has an optimum pH of 7 and its reactivity increases at pH values below 6.5 or above 8.5.

5-Chloro-7-methyl-1,3-benzoxazole-2-thiol is a benzoxazole that has been shown to have high binding affinity for the 5HT3 receptor in the distal colon. It has been proposed as a potential therapeutic agent for irritable bowel syndrome (IBS). This compound may be useful for treating IBS because it has been shown to act as an antagonist of the 5HT3 receptor, which is involved in the regulation of visceral pain. 5Chloro-7-methyl-1,3-benzoxazole-2-thiol does not bind to other receptors and does not show any agonist activity.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Amino-4-bromobenzene-1-thiol is a semiconducting polymer that can be used in devices such as solar cells, transistors, and sensors. It has electron deficient properties and is therefore able to form the backbone of a polymer. 2-Amino-4-bromobenzene-1-thiol is an electron donor that can be used for polymerization reactions with electron acceptors such as indigoid compounds. This compound has been shown to have optical absorption bands in the near infrared region, which are suitable for solar energy conversion applications.