Building Blocks

<p>2-Oxo-2H-chromene-6-sulfonamide is a coumarin derivative that has been shown to have pro-apoptotic properties. It induces apoptosis, or programmed cell death, in hepg2 cells by inhibiting the synthesis of proteins that are necessary for the growth and survival of cancer cells. 2-Oxo-2H-chromene-6-sulfonamide also inhibits the function of annexin and mcf7, two proteins involved in apoptosis. This drug has been shown to be effective against breast cancer cells in vitro. In addition, 2-Oxo-2H-chromene-6-sulfonamide has been found to inhibit the growth of human ovarian cancer cells in vivo. The toxicity studies on this drug have not yet been conducted on humans; therefore, it is not approved for use as a therapeutic agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Phenyl-1,2,4-oxadiazole-5-carbohydrazide (POD) is a heterocycle that has analgesic properties. It is an analgesic agent that belongs to the group of arylidene hydrazides. POD binds to the opioid receptors in the brain, which causes pain relief. POD is structurally related to dipyrone and has similar pharmacological profile. The drug was shown to be effective in reducing constrictions in guinea pigs and rats.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(5-Bromo-2-methylphenyl)ethanone is an aldehyde that is used in the treatment of cancer. It has been shown to have cytotoxic effects on tumour cells by inhibiting the process of mitosis, which is required for cell division. 1-(5-Bromo-2-methylphenyl)ethanone binds to kinesin and prevents it from binding to microtubules, which are necessary for mitosis. 1-(5-Bromo-2-methylphenyl)ethanone also inhibits the production of ATP, which is needed for cellular energy. 1-(5-Bromo-2-methylphenyl)ethanone has not been shown to be mutagenic or carcinogenic.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methanesulfinylbenzoic acid is an active site molecule that catalyzes the demethylation of alkylamines, amides, and cyclic sulfur compounds. The enzyme has been shown to have monooxygenase activity and can be biotransformed by various reactions including n-oxide formation, hydroxylation, sulfoxidation, and deamination. 3-Methanesulfinylbenzoic acid is a bacterial enzyme that has been crystallized in the x-ray crystal structures of both oxidized and reduced forms. The enzyme functions as a homodimer with a molecular weight of approximately 67 kDa.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Ethynylbenzamide is a synthetic compound that serves as an antibiotic. It is biosynthesized from the amino acid phenylalanine and the polyacetylene 4-hydroxyphenylacetone. The antibiotic activity of 4-Ethynylbenzamide has been demonstrated against gram-negative pathogens. The antibiotic inhibits bacterial growth by binding to the ribosomal protein S12, preventing its association with the 30S subunit of the ribosome and blocking protein synthesis. 4-Ethynylbenzamide also inhibits cell wall synthesis in gram-positive bacteria by binding to penicillin binding proteins, inhibiting transpeptidation and cell wall biosynthesis.</p>

<p>Indolizine-1-carboxylic acid (IDCA) is an antimicrobial agent that inhibits bacterial growth by interfering with the synthesis of proteins. IDCA is a fluorescent compound that can be detected using fluorescence spectroscopy. This drug has been shown to have potent cytotoxic effects against cancer cells, as well as antibacterial activity against Staphylococcus aureus and other bacteria.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>