Building Blocks

Cyclopentyl isothiocyanate (CPITC) is an organic solvent that is used as a pharmaceutical preparation. It has antiviral activity, which may be due to its ability to inhibit the serine protease of the virus. The hydroxy group on CPITC can react with the amide nitrogen of glutamine residues in protein and form an amide bond. CPITC has shown anticancer effects and inhibits the growth of cancer cells by inhibiting cell division at the G2/M phase. CPITC also has anti-inflammatory effects, which may be due to its ability to inhibit prostaglandin synthesis by blocking cyclooxygenase activity.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 2-Cyclopentyl-2-oxoacetate is a cyanoformate with the chemical formula C5H6O4. It is used as a reagent in organic synthesis and has been shown to react with stannic chloride to form a phosphonium salt. This reaction is followed by the addition of phosphorous pentachloride and potassium benzoate, which yields the corresponding phenylmagnesium chloride. The process can be completed by adding zinc chloride, which forms the desired organometallic compound.

3-(2-Methoxyphenyl)propanal is a heterocyclic compound that has been shown to be an efficient modulator of population growth. It has been found to be active against mosquitoes and inhibits the activity of phosphine. 3-(2-Methoxyphenyl)propanal binds to the surface of the mosquito’s mouthparts and prevents it from feeding, leading to death. The long-term effect on mosquito populations is not yet known. 3-(2-Methoxyphenyl)propanal has also been shown to inhibit trypsin and crystal x-ray diffraction, with five-membered ligands.

2,5,5-Trimethylcyclohexanone is a chemical that is used in the production of other chemicals. It can be produced by a reaction of formaldehyde with malic acid and ammonium formate. The reaction is catalyzed by metal surfaces such as nickel or platinum plates. Malic acid acts as a conditioner agent for the reaction system and ammonium formate functions as a catalyst. To produce 2,5,5-trimethylcyclohexanone, an organic solvent like hexane or toluene is heated to above its boiling point. When heated, the reactants are mixed together and passed over the catalyst surface at high pressure and temperature. This process produces 2,5,5-trimethylcyclohexanone in a gaseous state that can then be condensed into liquid form.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Hydroxy-3-methylpiperidine (4HMPD) is a heterocyclic compound that has shown to be a potent inhibitor of influenza virus. 4HMPD can be used as a drug to treat influenza in humans because it has the ability to inhibit the replication of human influenza viruses and is not toxic to humans. 4HMPD targets the influenza virus by binding to the viral nucleoprotein and inhibiting its function. The molecular structure of 4HMPD is similar to that of piperidine, which is an amino acid found in proteins. This similarity may help explain why 4HMPD inhibits influenza virus replication because amino acids are necessary for protein synthesis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Indapamide is a potassium-sparing diuretic with antihypertensive properties. It prevents the reabsorption of sodium and chloride in the kidney, which leads to increased urine volume. Indapamide is used for the treatment of hypertension in patients who are unable to control their blood pressure with diet and exercise alone. Indapamide has been shown to be effective in lowering blood pressure in hypertensive patients who have not responded well to other therapies.