Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-4-iodopyridine is a molecule that regulates the positioning of molecules. It has two different isomers, which have different conformational and intramolecular hydrogen bonding properties. 3-Bromo-4-iodopyridine is synthesized by reacting 3-bromopyridine with iodine monochloride in the presence of sodium hydroxide. This reaction produces a mixture of the two isomers, which can be separated using fractional crystallization or chromatography. 3-Bromo-4-iodopyridine has been shown to stabilize low efficiency solar cells.</p>

<p>4-Chloro-3-iodopyridine is a heterocyclic compound that has been used in the synthesis of tripeptides. 4-Chloro-3-iodopyridine can be synthesized by the cross-coupling of an unsymmetrical quinoline derivative and an iodide. This reaction is catalyzed by copper and produces a mixture of regioisomers. The isolated yield obtained from this synthesis was low, with only 3% being the desired product. The synthesis of 4-chloro-3-iodopyridine was also shown to have high yields when using anthracene as a starting material and halopyridines as coupling partners.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methyl-1,3-thiazole-5-carbohydrazide (MTZ) is a crystalline solid that has been shown to be stable in water and other polar solvents. It has been used as a precursor for the synthesis of sulfonyl chloride compounds. MTZ can be prepared by reacting benzenesulfonyl chloride with methyl iodide in the presence of potassium carbonate. This reaction results in an intermolecular S2 substitution on the benzene ring, which is stabilized by hydrogen bonding. MTZ reacts with Cl and Br to form chlorides and bromides respectively.</p>

<p>4-Amino-6-methylpyrimidine-2-thiole is a macrocyclic, polyhedra ligand that interacts with the extracellular domain of lipase. It has been shown to be bacteriostatic against Staphylococcus aureus and other bacteria. 4-Amino-6-methylpyrimidine-2-thiole can bind to the active site of the lipase and inhibit its function by preventing the release of fatty acids from chylomicrons and triglycerides. This drug also inhibits bacterial growth by binding to nucleobases, which are essential for DNA synthesis and transcription.</p>

<p>5,6-Dichloropyridazin-4-amine is an aminopyridazine that has been synthesized and studied as a potential therapeutic agent. It is a quinone with an azide group. The synthesis of 5,6-dichloropyridazin-4-amine can be achieved by reacting pyridazine with sulfuric acid, followed by the addition of chlorine and then ammonia. This reaction produces a mixture of the desired product, 5,6-dichloropyridazin-4-amine and other products such as 5,6-dichloroquinoxaline. This compound has shown to have antihypertensive activity in rats and may also have some medicinal properties due to its ability to inhibit the synthesis of betaines.</p>

<p>2-Sulfanyl-1,3-thiazole-4-carboxylic acid is a receptor binding compound that has been shown to bind to the prostaglandin E4 (EP4) receptor. This compound is an analog of prostaglandin F2α and has been shown to inhibit the binding of subtype EP4 receptors in a receptor binding assay. The structure activity relationship (SAR) of 2-sulfanyl-1,3-thiazole-4-carboxylic acid has been evaluated and optimized for maximum binding affinity with the EP4 receptor. These changes were found to be most effective in lowering blood pressure in rats.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>