Building Blocks

<p>5-Iodo-2-methoxypyrimidine is an enantioenriched, modular, polyfunctionalized, derivatized molecule that has been shown to be both antiproliferative and selective. It is synthesized in a two step reaction from acetate and 2-iodo-5-methoxypyridine via the use of a coupling agent, such as HATU. The synthesis proceeds with an arylation followed by a decarboxylative coupling reaction. This synthetic method produces 5-iodo-2-methoxypyrimidine in high yields with excellent enantioselectivity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,3-Dihydro-5(1H)-indolizinone (NU-120) is a quinoid compound that has been shown to have anti-oxidant and anti-inflammatory properties. The prodrug form of NU-120 is converted to the active n-oxide form in vivo by the enzyme cytochrome P450. This conversion takes place at an efficient rate with oral absorption between 0.2% and 2%. The drug has a crystalline structure and solvates readily in water.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

BIX is a redox potential-indicating reagent that has been used in the study of physiological effects and mechanisms. It is also an autophagy inducer and methyltransferase inhibitor. BIX has been shown to induce caspase-independent cell death in metastatic colorectal cancer cells. This agent has been used as an effective chemotherapy for hypoxic tumor cells and HIV infection, as well as for the treatment of plant physiology. BIX is a monosodium salt that is soluble in water and ethanol.

<p>2-[Benzyl(methyl)ao]propanoic acid is a glycine analogue that has been synthesized and characterized. It is an α-amino acid with the chemical formula C5H11NO2. The molecule has a chiral carbon atom at the center of the propanoic acid group and contains two asymmetric carbon atoms on the benzene ring, which enable it to exist in two stereoisomers. The compound has been shown to exhibit interligand interactions with copper as well as stereoselectivity in its interactions with l-amino acids. 2-[Benzyl(methyl)ao]propanoic acid also exhibits dichroism spectra, which are unique to these types of molecules.</p>

<p>4-(Iodomethyl)tetrahydro-2H-pyran is a synthetic cannabinoid that has been shown to bind to the CB2 receptor. It has been shown to have cannabimimetic properties and has been used as a research tool in drug product development. 4-(Iodomethyl)tetrahydro-2H-pyran has been found to have an EC50 of 2.6 μM for the CB2 receptor, which is higher than the EC50 for other synthetic cannabinoids (1.5 μM). This drug also binds to the cb1 receptor and can be used as a research tool in drug discovery.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>