Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Spiro[3.4]octan-1-one is an organic compound that is a 2-chloroethyl ketone. It can be prepared by the reaction of dimethyl sulfonium iodide with 2-chloroethanol. This chemical has been used as a reagent in the synthesis of polymers and pharmaceuticals.</p>

<p>3'-Chloro-4'-methoxyacetophenone (3'-CMA) is a chalcone that is used as an inhibitor of the enzyme acetylcholinesterase. It has been shown to inhibit the activity of acetylcholinesterase, which is responsible for the hydrolysis of acetylcholine. This inhibition leads to an increase in acetylcholine levels and therefore to an increase in the response time of skeletal muscle. 3'-CMA has been shown to have potentiating effects on other compounds, such as phenoxy, which are also inhibitors of acetylcholinesterase.</p>

<p>3-(4-Chloro-phenyl)-prop-2-yn-1-ol is a compound that can be synthesized by the reaction of 3-(4-chlorophenyl)propanal and ammonia. The reaction has been carried out in the presence of ammonium acetate, which acts as a catalyst to promote the formation of this product. This compound may be used for the synthesis of isoquinolines, which are biologically active compounds. The microwave irradiation technique is used for this synthesis to increase yields and decrease time.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Acetyl-2H-pyrazole-3-carboxylic acid ethyl ester is a potent and selective inhibitor of the enzyme carboxamide ribonucleotide transformylase (CRT). The pharmacodynamic properties of this compound are still unknown. 5-Acetyl-2H-pyrazole-3-carboxylic acid ethyl ester has been shown to inhibit tumour growth in xenograft models, but not in mice. It was also found to inhibit the proliferation of myeloproliferative cells, but not normal cells, in vitro. Further research is required to elucidate its mechanism of action and potential clinical applications.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(1-Aminocyclohexyl)acetic acid is a molecule that has been shown to have high cytotoxicity in the presence of hydrogen peroxide. It has been shown to be an inhibitor of β-aminoacyl-tRNA synthetase and RNA polymerase, which leads to reduced protein synthesis. The conformational properties and flipping of the cyclohexane ring have been studied using NMR spectroscopy.<br>(1-Aminocyclohexyl)acetic acid is also known as 1-aminocyclopentane carboxylic acid or ACPA.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Azepane-2,5-dione is a dopamine antagonist that blocks the activity of dopamine receptors by binding to them. It has been shown to antagonize the effects of dopamine in the brain and may be used for treatment of schizophrenia.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>