Building Blocks

<p>2',4'-Dichloropropiophenone is an organic solvent that is used in pharmaceuticals. It has been shown to be a versatile reagent for the synthesis of chalcones and other types of compounds. 2',4'-Dichloropropiophenone can be used in the cross-coupling reaction, which involves the coupling of two organic molecules using a metal catalyst (usually copper) to generate new compounds. The dehydrohalogenating reaction, which involves the conversion of epoxides into alcohols, can be performed with 2',4'-dichloropropiophenone. This compound also reacts with amines to form oximes or aziridines and with epoxy groups to form epoxy ethers. Finally, it is an oxidant that can react with benzene to produce phenols, biphenyls, or nitrobenzenes.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Quinoxalines are a class of heterocyclic compounds that is structurally related to the more common amino acid, tryptophan. They are typically synthesized by modifications of the quinoxaline ring system with epoxide, amine, or carbonyl groups. Quinoxalines can be analyzed using many different techniques including gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, and nuclear magnetic resonance spectroscopy. The most common modification is the addition of an aminoguanidine group that is used to distinguish between 2-ethyl-3-methylquinoxaline and 3-ethyl-2-methylquinoxaline. The reaction time between glyoxal and aniline to produce 2-ethyl-3-methylquinoxaline can be optimized by adding potassium dichromate as a catalyst.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>5,6,8,9-Tetrahydrobenzocyclohepten-7-one is a methylated analogue of benzocycloheptene. It is prepared by the reaction of dichlorocarbene (1) with 7-hydroxybenzocycloheptene (2). The deuterium isotope effect on the conformation of 5,6,8,9-tetrahydrobenzocyclohepten-7-one has been investigated using a spectroscopic technique. The reaction parameters have been optimized for this transformation to produce the desired product in high yield.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3H,4H-Pyrido[3,2-d][1,2,3]triazin-4-one is a heterocyclic compound that belongs to the group of endometriosis drugs. It has been shown to inhibit tyrosine kinase and thus has a proliferative effect on the skeleton. 3H,4H-Pyrido[3,2-d][1,2,3]triazin-4-one also has an antiangiogenic activity that prevents the formation of new blood vessels from pre-existing ones. This drug also inhibits tumor growth by blocking cell division and may cause cancerous cells to self destruct. 3H,4H-Pyrido[3,2-d][1,2,3]triazin-4-one can be used to treat symptom of endometriosis such as pain and infertility.</p>

<p>Ethyl 1H-pyrrole-3-carboxylate is a nitro compound that has been shown to be efficient and multisubstituted. It reacts with carbon monoxide to form a nitro group, which can then be reduced by reductive means. Ethyl 1H-pyrrole-3-carboxylate is also capable of forming vinyl or carbonyl compounds in the presence of appropriate reagents.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-4-ethynylpyrimidine is a chemical compound that belongs to the family of meridianins. It has been shown to have medicinal properties, and is used in the treatment of trypanosomiasis. This molecule also has physicochemical properties that warrant further investigation. Optimization studies have shown that 2-chloro-4-ethynylpyrimidine can be synthesized with yields of up to 76% using nitrosoarenes as reactants.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Nitro-3-(phenylsulfanyl)benzene is a compound that belongs to the class of organic compounds with a molecular formula C11H10O3S. It has a transmittance of 0.10 and a polycondensation value of 3.2. The conformation of 1-nitro-3-(phenylsulfanyl)benzene is linear, and it has an average refractive index of 1.5214. This compound has high stabilities, as well as being n-methyl-2-pyrrolidone and sulfur stable, with birefringence values of 0.0805 and -0.0125 respectively. The steric effect on this compound is negligible, with the refractive index being polarizable in optical activity experiments, with an average optical rotation value of -5°/Mol at 20°C (298K).</p>