Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Naphthalene-2-carboximidamide is a benzamidine derivative that interacts with the active site of serine proteases. It was shown to have potent inhibitory potency against a number of proteinases, including urokinase-type plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), and cathepsin G. The interaction of naphthalene-2-carboximidamide with uPA was specific and led to inhibition of its catalytic activity. Naphthalene-2-carboximidamide has been tested in clinical trials for the treatment of influenza.</p>

<p>Versatile small molecule scaffold</p>

<p>1-N-(methylsulfonyl)-4-piperidinone is a compound that belongs to the group of secondary organic amines. It can be used as an intermediate in the synthesis of p-hydroxybenzoic acid and hydroxyl group compounds. 1-N-(methylsulfonyl)-4-piperidinone has been shown to inhibit protein synthesis in cultured cells by blocking the formation of aminoacyl-tRNA and preventing translocation of peptide chain from ribosomes to the site of peptide bond formation. This process is essential for the production of proteins, which are necessary for normal cell function. The inhibitory effect on protein synthesis was also observed when 1-N-(methylsulfonyl)-4-piperidinone was incubated with human erythrocytes, an enzyme isolated from calf thymus, and a monoclonal antibody (mAb). This mechanism is believed to be due</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,4-Dimethoxyphenyl isothiocyanate (DMITC) is a molecule that has been shown to have pro-apoptotic activity against human colorectal carcinoma cells. It also inhibits the growth of the colon cancer cells by inducing apoptosis. DMITC has been shown to inhibit the synthesis of DNA and RNA in a dose-dependent manner. This molecule is efficiently synthesized by reacting an imine with an isothiocyanate. DMITC has cytometric analysis for mechanistic studies and can be used as a chemotherapeutic agent for cancer treatment.</p>