Building Blocks

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Bromoimidazo[1,2-a]pyridine is an inhibitor of the mitotic kinesin KIF5B. It is a bicyclic compound that has been shown to inhibit cellular activity and tumor growth in preclinical models. 5-Bromoimidazo[1,2-a]pyridine blocks the interaction between KIF5B and histone H3, preventing mitosis, which leads to cell death. This drug has also been shown to inhibit the proliferation of cancer cells in vitro and in vivo.</p>

<p>2,2,2-Trichloroethyl sulfamate is a reactive molecule that can be synthesized through the aziridination of 2-chloroethanol with sodium azide. It undergoes the reaction with sulfamic acid in the presence of copper to form a sulfamate. The chemical properties of this molecule have been studied using X-ray diffraction data and found that it has bioactive molecules and is a potential agent for kidney cancer treatment. 2,2,2-Trichloroethyl sulfamate also has transfer reactions with other compounds such as formaldehyde and amines. These reactions are influenced by factors such as the reaction time and the pH.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>6-Bromo-1,2,4-triazin-3-amine is an inhibitor of the c-MET kinase that can be used for the treatment of cancer. 6-Bromo-1,2,4-triazin-3-amine inhibits the activation of the c-MET and other kinases by interfering with their ability to bind to ATP. 6BTA inhibits tumor cell proliferation through inhibition of crosstalk between growth factor receptors and downstream signaling pathways. It has been shown to inhibit tumor growth in vivo and in vitro.</p>

<p>2-Methylthian-3-one is an alkylating agent that has been used to synthesize substituted pyridines. It is a six-membered ring with two methyl groups on the same side of the ring, which gives it its name. This compound has been shown to undergo stereoselective alkylation reactions at carbons adjacent to both the axial and equatorial positions with alkyl halides. The chemical shift for 2-methylthian-3-one is constant, at -1.6 ppm in chloroform solution and -0.5 ppm in DMSO solution. The parameters that affect the chemical shift are conformational and axial substituents on the ring, as well as substitution patterns on the other carbon atoms of the molecule.</p>

<p>3,6-Dibromoquinoline is a synthetic, kinetic isotope that has been used to assess the mechanistic effects of heterocycles in base catalysis. This research was conducted using deuterated 3,6-dibromoquinoline and assessing the isotope effects on kinetic isotopes. The kinetic isotope effects were measured using a gas chromatograph with a flame ionization detector (GC-FID) and a mass spectrometer (MS).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>