Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Methoxy-2-nitro-phenyl)-acetonitrile is an analog of β-unsaturated ketones and has been synthesized from phenylmagnesium bromide, amido acid, and α-(chloromethyl)benzene. The reaction was stereoselective with the formation of a single diastereomer. 5-Methoxy-2-nitro-phenyl)-acetonitrile is a chiral compound with two asymmetric carbon atoms. The synthesis of this compound was efficient, requiring only four steps to complete the entire process.</p>

<p>Versatile small molecule scaffold</p>

<p>5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline is a crystalline organic solvent that is used industrially as a precursor to the benzyl group in organic synthesis. It can be used to synthesize lifitegrast through catalytic elimination of butyl lithium. 5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline has two crystalline polymorphs: form I and form II. Form I has a melting point of 191°C and form II has a melting point of 190°C. The industrial scale production of 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline is typically achieved by hydrogenation of the corresponding nitro compound.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Thiazol-2-yl)ethanol is a molecule that belongs to the class of thiazolines. It has been shown to have a physiological effect on probiotic bacteria and is used as a prebiotic. 2-(Thiazol-2-yl)ethanol can be synthesized by coupling the corresponding acid chloride with an alcohol in the presence of an acid catalyst. This molecule is being investigated for its potential use as a therapeutic agent against infectious diseases, such as colitis. 2-(Thiazol-2-yl)ethanol also affects enzyme activities, regulatory proteins, and transcriptional regulation in model systems. This molecule may play a role in energy metabolism and protein synthesis through its interaction with enzymes, regulatory proteins, or transcriptional regulators.</p>

<p>5-Formylthiophene-3-carboxylic acid is an inhibitor of the cycloaddition reaction between azomethine and enamines. It has been shown to be diastereoselective, inhibiting the formation of the undesired enantiomer. The synthesis and characterization of this compound has been used in process research for drug discovery.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>9-Bromo-1-nonene is a hydroxy group, halide, and solute. It has been shown to undergo reductive elimination with cyclodehydration to form 9-bromononane. 9-Bromo-1-nonene has also been used as an actuator in phase liquid chromatography (also called high performance liquid chromatography). It is stereoselective and exhibits inhibitory activities against anomala, glycosidases, and magnetic particles. This compound is also soluble in diethyl ether.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>