Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Phenyl-1,3,4-oxadiazole-2-carboxamide (PDC) is a quaternary ammonium salt that has been shown to inhibit the growth of methicillin-resistant Staphylococcus aureus and other gram-negative bacteria. PDC inhibits the synthesis of proteins by binding to ribosomes in the bacterial cell wall. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme ribosome that is required for protein synthesis and cell division. PDC also has antimicrobial properties and can be used as an antibacterial agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Hydrazinoquinoline hydrochloride is a cation with a molecular weight of 176.2. It is cytotoxic and inhibits cancer cell growth. 4-Hydrazinoquinoline hydrochloride has been shown to be effective against lymphoid, breast, colon, and prostate cancer cells in vitro with IC50 values of 0.5 to 2 μM. This drug has been shown to bind to DNA by forming a Schiff base with the amine group of guanine residues in the DNA backbone. This binding leads to changes in DNA conformation that inhibit transcription and replication as well as protein synthesis and cell division.</p>

<p>4-(5-Formylfuran-2-yl)-N-methylbenzene-1-sulfonamide is a synthetic, antiparasitic and antibiotic drug that has been shown to possess antiviral and antifungal properties. It is an inhibitor of DNA synthesis and RNA transcription by blocking the enzyme RNA polymerase II, and also inhibits protein synthesis by inhibiting the enzyme ribosomal protein S12. 4-(5-Formylfuran-2-yl)-N-methylbenzene-1-sulfonamide is effective against both Gram positive and Gram negative bacteria, as well as yeast. The compound has been shown to be active against bacteria such as Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica serovar Typhi, Staphylococcus aureus (MRSA), Mycobacterium tuberculosis, Mycobacterium avium complex, Candida alb</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Chloro-8-nitroquinoline is an indian nitro compound that yields a greenish yellow liquid when reacted with quinaldine, which is an aromatic amino compound. The 8-nitroquinoline group in this compound has an amino group and reacts with the fungitoxicant guanidine. This class of compounds is used to control fungi such as Aspergillus and Myrothecium verrucaria. 6-Chloro-8-nitroquinoline can be hydrolyzed by strong acids or bases, yielding chloro formates.</p>

<p>4-(1H-1,2,3-Triazol-1-yl)phenol is a small molecule that has been shown to enhance the efficiency of diagnosing certain conditions. It can be used in microwells as a sensor for measuring the concentration of analytes such as antibodies, enzymes, proteins, and other compounds. This compound is immobilized on a solid surface and reacts with light to produce chemiluminescence. 4-(1H-1,2,3-Triazol-1-yl)phenol can be used as an immobilization agent for magnetic beads and also has fluorescent properties. It has been shown to inhibit hepatitis B virus replication by binding to the viral antigen. 4-(1H-1,2,3-Triazol-1-yl)phenol is also able to detect peroxide in biological fluids or luminol in animal tissue.</p>

<p>Versatile small molecule scaffold</p>