Amines

<p>Applications Used for the preparation of dihydrouracils as anti-ictogenic or anti-epileptogenic agents.<br>References Akoulitchev, S., et al.: Nature, 377, 557 (1995), Marshall, N., et al.: J. Biol. Chem., 270, 12335 (1995), Marshall, N., et al.: J. Biol. Chem., 271, 27176 (1996), Shapiro, G., et al.: J. Clin. Oncol., 24, 1770 (2006),<br></p>

<p>Applications (1R)-2,3-Dihydro-N-2-propen-1-yl-1H-inden-1-amine Ethanedioate is an intermediate used in the synthesis of propargylated aminoindan derivatives via allylation, bromination, dehalogenation sequence.<br>References Phull, M., et al.: PCT Int. Appl., WO 2009081148 A1 20090702 (2009)<br></p>

<p>Impurity Tiamulin Hydrogen Fumarate Impurity C<br>Applications Reagent used in the addition of Thiobistriethylamine.<br>References Evers, M., et al.: Bioorg. Med. Chem. Lett., 13, 4415 (2003),<br></p>

<p>Applications N-(2-Chloroprop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine is related to the drug Rasagiline(R126030). Rasagiline is used to increase the availability of dopamine at striatal receptors as a method to treat Parkinson’s disease.<br>References Youdim, M.B.H., et al.: Br. J. Pharmacol., 132, 500 (2001); Finberg, J.P., Rambam Maimonides Med. J., 1 (2010)<br></p>

<p>Applications Methyl 2-Aminothiazole-5-carboxylate (cas# 6633-61-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Amino(3-​chlorophenyl)​acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.<br>References Hansch, C., et al.: J. Med. Chem., 13, 957 (1970); Holdrege, C. T., et al.: Can. (1975), CA 966853 A2 19750429;<br></p>

<p>Applications ethyl 3-aminobutanoate (cas# 5303-65-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 12-(tert-Butoxycarbonylamino)dodecylamine can be used to synthesize inhibitors of topoisomerase I for use as anticancer agents.<br>References Cinelli, M., et al.:Bioorg. Med. Chem., 17, 7145 (2009); Morrell, A., et al.: J. Med. Chem., 50, 2040 (2007)<br></p>

<p>Applications 4-Aminoindan is a reactant in the preparation of a UBLCP1 proteasome phosphatase inhibitor.<br>References He, Y., et. al.: Bioorg. Med. Chem., 23, 2798 (2015)<br></p>

<p>Applications Mono and dibasic phosphate esters are anionic surfactants which have the main feature of the stability in alkaline conditions over other surfactants. They have a wide range of properties including outstanding wetting, emulsification, lubrication, coupling activity and detergency.<br>References Ramirez, F., et al.: Tetrahedron, 35, 1581 (1979);<br></p>

<p>Applications 3-DI-N-PROPYLAMINO-1-PROPYNE (cas# 6323-79-1) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br></p>

<p>Applications O,O-Dibutyl Phosphorodithioate is an intermediate used to prepare oligodeoxyribonucleoside phosphorodithioates.<br>References Okruszek, A., et al.: J. Org. Chem., 60, 6998 (1995)<br></p>

<p>Stability Volatile<br>Applications In the presence of sugars, lysine, similarly to asparagine and phenylalanine, can undergo carbonyl-assisted decarboxylative deamination reaction to generate pent-4-en-1-amine, the counterpart of acrylamide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stadler, R., et al.: Chem. Res. Toxicol., 16, 1242 (2003), Stadler, R., et al.: J. Agric. Food Chem., 52, 5550 (2004),<br></p>

<p>Applications Used in the antileishmanial activity of lipidic amino alcohols.<br>References Coimbra, E.: Chem. Biol. Drug Des. 75, 233 (2010).<br></p>

<p>Applications 3-AZIDOPROPAN-1-AMINE (cas# 88192-19-2) is a useful research chemical.<br></p>

<p>Applications 6-Amino-1,3-dimethyl-5-nitrosouracil (cas# 3346-61-0) is a compound useful in organic synthesis.<br>References Varma, R., et al.: J. Ocular Pharmacol. Ther., 16, 571 (2000),<br></p>

<p>Applications 2-Amino-N-benzylbenzamide can be used for drug discovery and pharmaceutical manufacturing.<br>References Amini-Rentsch, L., et.al., Ind. Eng. Chem. Res., 58, 10164-10171, (2019);<br></p>

<p>Applications O-((Perfluorophenyl)methyl)hydroxylamine Hydrochloride functions as one of the substances used in the identification of stable cytotoxic factors in extracts of cigarette smoke and in the pharmacological characterization of their cytotoxicity.<br>References Noya Y., et al.: Toxicology, 314, 1 (2013)<br></p>

<p>Applications (2R)-1-(9H-Purin-6-ylamino)-2-propanol is a reagent for the synthesis of tenofovir disoproxil fumarate, a medication for the treatment of hepatitis B and to prevent and treat HIV/AIDS.<br>References Yan, N., et al.: Jingxi Huagong, 31, 983 (2014); Ripin, D. H. B., et al.: Org. Process Res. Dev., 14, 1194 (2010)<br></p>

<p>Applications 3-(methylamino)butan-1-ol (cas# 2704-55-4) is a useful research chemical.<br></p>

<p>Applications (3-Aminopropyl)trimethoxysilane is used in the synthesis of aspirin imprinted polymer on silica gel surface and appreciation on drug sustained release. Fluorine-doped; lectin functionalized ZnO nanoarrays as 3D nano-biointerface for bacterial detection.<br>References Lu, P., et al.: Gaofenzi Cailiao Kexue Yu Gongcheng, 33, 130 (2017); Zheng, L., Talanta, 167, 600 (2017)<br></p>

<p>Applications Clavulanic Acid 2-Amino-2,4,4-trimethylpentane Salt is an intermediate in the synthesis of Clavulanic Acid Potassium Salt (C563750), a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977); Ball, A.P., et al.: Lancet, 1, 620 (1980); Brogden, R.N., et al. Drugs, 22, 337 (1981)<br></p>

<p>Applications Ethyl (Z)-3-(Dimethylcarbamoylamino)-4,4,4-trifluoro-but-2-enoate is an intermediate in the synthesis of Tiafenacil (T436300), which is a uracil herbicide used as a pesticide for the prevention and control of plants.<br>References Peng, X., et al. Faming Zhuanli Shenqing, 68pp Patent 2018 CODEN:CNXXEV<br></p>

<p>Applications 2-Amino-4,5-dimethylthiophene-3-carbonitrile is a useful research chemical for organic synthesis and other chemical processes.<br>References Rahman, K. M. M., et al.: Pakistan J. Sci. Ind. Res., 46, 95 (2003); Madhavi, K., et al.: Res. J. Pharm. Biol. Chem. Sci., 8, 387 (2017)<br></p>

<p>Applications Tris(N,N-dimethylaminopropyl)amine has been used in the synthesis of nickel(II) and cobalt(II) complexes with the propylene-bridged tripod ligand tris(3-dimethylaminopropyl)amine (donor set N4).<br>References Morassi, R., Dei, A.: J. Chem. Soc., 12, 2024 (1971)<br></p>

<p>Applications N-Carbobenzoxy-1,4-diaminobutane HCl is used in the synthetic preparation of pyrazolyl glucopyranoside and galactopyranoside derivative inhibitors of human sodium-glucose cotransporter 1 (SGLT1) for preventives or therapeutics for diseases related to hyperglycemia or galactosemia.<br>References Teranishi, H.; et al.: PCT Int. Appl. 215 pp. Patent 2004 CODEN:PIXXD2<br></p>

<p>Applications 6-Amino-5-nitrouracil (cas# 3346-22-3) is a compound useful in organic synthesis.<br>References Graves, A., et al.: J. Mol. Biol., 377, 914 (2008),<br></p>

<p>Applications Phosphorylating reagent.<br>References Santner, T. et al.: Bioorg. Med. Chem, 20, 2416 (2012); Sun, D. et al.: ChemMedChem, 4, 1649 (2009)<br></p>

<p>Applications 2-((tert-bButoxycarbonyl)amino)-2-(hydroxymethyl)-4-(4-octylphenyl)butyl Acetate is the intermediate in the synthesis of Mono-O-acetyl Fingolimod TFA (F524600), which is an impurity of Fingolimod (F805000, HCl salt) which is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001). Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002). Mtaloubian, M., et al.: Nature, 427, 355 (2004)<br></p>

<p>Applications 2,2-Diethoxy-N-ethylethanamine is used in the preparation of 1-substituted-2-mercaptoimidazoles with antithyroid activity.<br>References Jones, R.G.J. Am. Chem. Soc., 71, 4000 (1949)<br></p>

<p>Applications 2-Amino-2-cyclopropylpropanenitrile, is an enamine building block that can be used in the synthesis of various chemical compounds, such as in synthesis of 5-substituted hydantoins, and Ketone-Derived Enamides.<br>References Murray, R. G. et al.: Organic &amp; Biomolecular Chemistry, Vol: 6, P: 988-99 1 (2008); Coussanes, G. et al.: euro. J. Org. Chem, Vol 2016, P: 4176-4188 (2016);<br></p>

<p>Applications Tetramethylammonium Hydroxide is used to prepare a new family of silicate/aluminosilicate mesoporous molecular sieves.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Beck, J., et al.: J. Am. Chem. Soc., 114, 10834 (1992).<br></p>

<p>Applications Methyl (2S)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoate<br></p>

<p>Applications A caged, photolabile Nitric Oxide donor that is useful for delivering nitric oxide into intracellular compartments in microsecond time scale without any cytotoxic effects.<br>References Namiki, S., et al.: Bioorg. Med. Chem., 7, 1695 (1999),<br></p>

<p>Applications Amino-peg1-t-butyl Ester is a reagent used in the preparation of β2 adrenergic receptor agonists and muscarinic receptor activity antagonists.<br>References Donald, D. K., et al.: PCT Int. Appl., WO 2011048409 A1 WO2010-GB51751 (2011)<br></p>

<p>Applications tert-Butyl 2-(3-Aminophenyl)acetate can be used as anti-heparanase to treat diseases and disorders associated with heparanase activity.<br>References Giannini, G., et.al.: PCT Int. Appl., 103, (2018);<br></p>

<p>Applications Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is used in the preparation of dendronized polymers. Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine can be used in the synthesis of optically degradable dendrons for temporary adhesion of proteins to DNA. It is also used in the preparation of tricylic polyamide receptor for carbohydrate recognition.<br>References Calderon, M. et al.: Macromol. Sym., 258, 53 (2007); Kostiainen, M.A. et al.: Chem. Eur. J., 16, 6912 (2010); Klein, E. et al.: Angew. Chem. Int. Ed., 44, 298 (2005);<br></p>

<p>Applications Ammonium Bromide is used as a bromide activated chloramine biocide for effective control of volatile fatty acids and catalase and biofilm elimination in paper making industry. Also applied in biopharmaceuticals and dosage form designs.<br>References Bharati, S., et al.: Appita J., 56, 426 92003); Torosian, G., et al.: Am. J. Hosp. Pharm., 30, 716 (1973)<br></p>

<p>Applications 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate (cas# 99-43-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethyl 2-(2-Aminothiazol-4-yl)glyoxylate is used in the synthesis of antibacterial compounds. Also used in the synthesis of antiallergic and antiinflammatory agents, as glycolic amide derivatives.<br>References Takasugi, H. et al.: J. Antibio., 36, 846 (1983); Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);<br></p>

<p>Applications N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide (cas# 10558-45-9) is a useful research chemical.<br></p>

<p>Applications 2-Benzylthio-5-amino-1,3,4-thiadiazole is used to study and investigate its antitumor activities against human cervix adenocarcinoma(HeLa), human liver cancer cell(SMMC-7721), human breast cancer cell(MCF-7) and human lung cancer cell(A549) lines that isfurther evaluated by CCK-8 assay.<br>References Zhao, J., et. al., Chem. Res. Chin. Univ.,30, 764-769 (2014)<br></p>

<p>Applications O-Cyclopropylmethyl-hydroxylamine, Hydrochloride (cas# 74124-04-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-phenylcyclohexanamine (cas# 19992-45-1) is a useful research chemical.<br></p>

<p>Applications (S)-2-Amino-3-(4-aminophenyl)propan-1-ol is derived from (2S)-2-Amino-3-(4-nitrophenyl)-1-propanol (A618365), which can be used as an intermediate in the synthesis of various pharmaceutical compounds. It is used in the preparation of a new series of 2-substituted thiazole carboxamides as potent inhibitors of Akt kinases.<br>References Shaohua, Ch., et al.: Bioorg. Med. Chem. Lett., 22, 1208 (2012);<br></p>

<p>Applications 6-​Amino-​5-​nitrochromen-​2-​one is a reagent used in the synthesis of pyranopyridinediones.<br>References Khan, M. et al.: J. Pure App. Sci., 22, 37 (2004);<br></p>

<p>Applications Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br></p>

<p>Applications 6-Aminohexanenitrile (cas# 2432-74-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4'-Dimethylaminophenyl acetylene<br></p>

<p>Applications 1-Phenyl-2-(p-tolyl)ethylamine is an intermediate used to prepare γ-nitroaldehydes with quaternary stereogenic centers.<br>References Angewandte Chemie, International Edition, 52, 7228 (2013)<br></p>

<p>Applications A reactant used in the preparation of (-)-Amathaspiramide F.<br>References Sakaguchi, K. et al.: Tetrahedron, 65, 10355 (2009); Sakaguchi, K. et al.: Org. Lett., 10, 5449 (2008)<br></p>

<p>Applications 4-​(Dimethyloxidoamino)​butanoic Acid Hydrochloride, is a metabolite of Lauramine Oxide (L178530), which is a frequently used amine oxide surfactant. It is strongly hydrophilic , and it forms normal micelles and normal liquid crystalline phases.<br>References Kocherbitov, v., et al.: J. Molec. Struct.: Theochem., 808, 111 (2007); Kocherbitov, v., et al.: J. Phys. Chem. B., 110 (27), 13649 (2006); Turan, T.S., et al.: Xenobiotica, 11, 447 (1981)<br></p>

<p>Applications 2-(3-Aminopropylamino)ethanol is the hydroxy analogue of WR-1065 (A576820), a metabolite of Amifostine (A576810). Amifostine is an organic thiophosphate that has the ability to protect a broad range of tissues from cytotoxicity (e.g. from chemotherapeutic agents) without inducing an antitumour response. 2-(3-Aminopropylamino)ethanol is also used as an nucleophilic tag in the detection of human butyrylcholinesterase adducts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Antonadou, D., et al.: Int. J. Rad. Oncol. Biol. Phys., 52, 739 (2002); Kemp, G., et al.: J. Clin. Oncol., 14, 2101 (1996)<br></p>

<p>Applications 4-Isopropyl-1,3-thiazol-2-amine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications O-Benzylmetaraminol is an impurity of M225565.<br></p>

<p>Applications 2-[6-(Acetylphenylamino)-1,3,5-hexatrienyl]-1,1-dimethyl-3-sulfobutyl-1H=-benz[e]indolium Inner Salt is a reactant used in the preparation of indocyanine green as an infrared probe.<br>References Suganami, A. et al.: Bioorg. Med. Chem. Lett., 22, 7481 (2012); Doi, T. et al.: Synlett., 23, 306 (2012);<br></p>

<p>Applications Used in the preparation of (R)-Sulforaphane (S699105).<br></p>

<p>Applications 2-Aminomethyl-1,4-benzodioxane is used in the synthesis of N-substituted (dihydrobenzodioxinyl)methylamine derivatives as D2 antagonists/5-HT1A partial agonists with potential as atypical antipsychotic agents in relation to affinity for α1 adrenoceptors.<br>References Birch, A. M., et al.: J. Med. Chem., 42, 3342 (1999);<br></p>