Halogenated Compounds

<p>Applications 1-Bromotridecane-10,10,11,11,12,12,13,13,13-d9 is a useful isotopically labeled compound of 1-Bromotridecane (B688365)<br></p>

<p>Applications 2,4'-Dibromobenzophenone (CAS# 78281-59-1) is a useful research chemical compound.<br></p>

<p>Applications 1-(3-Chloro-2-hydroxypropyl)-2-nitroimidazole is an intermediate in the synthesis of 1-(2,3-Epoxypropyl)-2-nitroimidazole (B592583) which is an intermediate in the synthesis of Pimonidazole-d10 (P447814). Isotope labelled Pimonidazole (P447813) is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It abels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.<br>References Sato et al.: PLoS One 11 e0165946 PMID:(2016); Bennewith et al.: Cancer Res. 62 6827 PMID: 12460894, (2002)<br></p>

<p>Applications 4,5-Dibromo-2-benzoylpyrrole is used in preparation of 2,3-Dibromo-5-benzoyl Pyrrole via amidation of morpholine with Benzoyl Chloride, followed by Friedel-Crafts reaction with pyrrole and substitution with Br2.<br>References Yang, Q., et al.: Faming Zhuanli Shenqing, (2012);<br></p>

<p>Applications Ethyl 4-Chloroacetoacetate (E901800) is the parent compound for Ethyl 4-Chloro-2-ethyl-3-oxobutanoate. Ethyl 4-Chloroacetoacetateis used in the production of Ethyl (R)-4-Chloro-3-hydroxybutyrate. Also in preparation of Tricyclic substituted Piperidine dione comppunds useful for the treatment of diseases related to CRBN protein.<br>References Ding, X., et al.: Faming Zhuanli Shenqing, (2019); Luo, Y., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications 1-CHLOROHEXANE (cas# 544-10-5) is a useful research chemical.<br></p>

<p>Applications 4-((4-Chlorophenyl)(phenyl)methyl)-1,1-Bis(2-(2-hydroxyethoxy)ethyl)piperazin-1-ium Bromide is a useful research compound.<br></p>

<p>Applications 5-(4-Chloro-3-fluorophenyl)-2-furoic Acid is an impurity of 5-(3-Chlorophenyl)-2-furoic Acid (C378150); a reagent in the synthesis of Dantrolene (D185000) which has the potential to treat vascular dysfunction.<br>References Ellis, K.O., et al.: J. Pharm. Sci., 69, 327 (1980); Harrison, G.G., et al.: Brit. J. Anaesth., 60, 279 (1988); Murasawa, S., et al.: Bioorg. Med. Chem., 20, 6384 (2012)<br></p>

<p>Applications N-(2,4-Dichloro-5-methoxyphenyl)acetamide is a reactant used in the chlorination of acetanilides with benzyltrimethylammonium tetrachloroiodate(B316185).<br>References Kajigaeshi, S., et al.: Bull. Chem. Soc. Jpn., 63, 941 (1990)<br></p>

<p>Applications 5-FLUORO-2,3-DIHYDROBENZOFURAN (cas# 245762-35-0) is a useful research chemical.<br></p>

<p>Applications 1-Bromodecane-10,10,10-d3 (CAS# 284474-47-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2,4-Trichlorobenzene- 13C6 is the labeled form of 1,2,4-Trichlorobenzene (T774220). It is an intermediate in the synthesis of PCB 101-13C12 (P216628) which is a related compound of PCB 189-13C12(P216622), which is a flame retardant and a standard for environmental testing and research.<br>References EPA. Method 1668, (EPA 821-R-00-002) (1999)<br></p>

<p>Applications N-(2-Bromo-5-fluorophenyl)acetamide is a reagent in the preparation of fluorinated rhodacyanine analogues with antileishmanial properties.<br>References Lasing, T., et al.: Bioorg. Med. Chem., 28, 115187 (2020)<br></p>