Ethers

<p>Intermediate in the synthesis of osimertinib (AZD9291)</p>

<p>4-Fluoro-2-methoxyphenol is a fluorinating agent that is used in the manufacture of pharmaceuticals, plastics and pesticides. It has been shown to induce apoptosis in cultured cells by upregulating reactive oxygen species (ROS) and increasing mitochondrial membrane permeability, as well as inhibiting cellular physiology. 4-Fluoro-2-methoxyphenol also inhibits the production of ATP and may be toxic to cells by interfering with dinucleotide phosphate.</p>

<p>Candesartan is a selective angiotensin II receptor antagonist that inhibits the binding of angiotensin II to its receptors, which in turn decreases the activity of angiotensin-converting enzyme. Candesartan cilexetil is an ester prodrug that has been shown to be effective in the treatment of high blood pressure. In the crystalline form, candesartan cilexetil is a white powder with a melting point of 130–135 °C and a solubility in water of &gt;1 g/L. The molecular weight of candesartan cilexetil is 393.8 g/mol and it has a molecular formula C17H21NO2S. The chemical structure consists of two benzimidazole rings coupled together through an ethyl-2-ethoxy linker and attached to a carboxylate group on one end and an amide group on the other</p>

<p>2-Amino-2-oxoethoxy)acetic acid is a product that can be used as a transport agent in the process of extracting glycosides. It has been shown to have strong adsorption properties and is able to extract glycosides from plant material. 2-Amino-2-oxoethoxy)acetic acid has a high affinity for calcium, which is an important component in the adsorption mechanism.</p>

<p>4-Chloro-6,7-dimethoxyquinoline (4C6DMQ) is a potent inhibitor of the growth of prostate cancer cells. 4C6DMQ is an analog of chloropropyl chloride, which inhibits the growth of epidermal growth factor receptor (EGFR). The binding site for 4C6DMQ on EGFR is the same as that for chloropropyl chloride. 4C6DMQ inhibits EGFR by preventing the activation of downstream signaling cascades, leading to a decrease in cell proliferation and tumor size. The IC50 values for 4C6DMQ are approximately 10 times higher than those for chloropropyl chloride. This drug has been shown to be more potent than other inhibitors of EGFR such as erlotinib and gefitinib.</p>

<p>3,4',5-Trimethoxystilbene is a coumarin derivative that has been found to have inhibitory properties for mitochondrial functions. It also inhibits the production of epidermal growth factor and collagen synthesis in cells. 3,4',5-Trimethoxystilbene may be useful in treating skin conditions such as psoriasis and ichthyosis. This compound has been shown to bind to protein targets in the mitochondria and inhibit mitochondrial membrane potential by hydroxyl group reaction with proteins. 3,4',5-Trimethoxystilbene also binds to dna duplexes, which may affect its biological properties.</p>

<p>Dibenzoyl-(-)-p-methoxy-L-tartaric acid is a chiral compound that has been extracted from plants and synthesized. It has a bitter taste and can be used as an enantiomer to treat schistosomiasis, a disease caused by parasitic flatworms. Dibenzoyl-(-)-p-methoxy-L-tartaric acid can be used as an enantiomer to treat schistosomiasis, which is caused by parasitic flatworms. The chemical is an anionic β-cyclodextrin derivative that binds to the parasites in the host's body and prevents them from releasing eggs into the water supply. This chemical also has pharmacological properties, such as antiinflammatory activities.</p>

<p>2-Bromo-5-hydroxy-4-methoxybenzaldehyde is a death pathway inhibitor that has been shown to have radiosensitizing effects in vitro. It has also been found to inhibit the expression of matrix metalloproteinase (MMP) in human glioma cells and in a rat model of cerebral ischemia. This compound may be used as a potential chemotherapeutic agent for the treatment of cancer. 2-Bromo-5-hydroxy-4-methoxybenzaldehyde inhibits cell proliferation by inducing apoptosis, or programmed cell death, which may be due to its ability to suppress MMP activity.</p>

<p>2-[(4-Chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutanamide is a chelating agent that has been used as a control agent in the manufacture of dyes, plastics, and rubber. It is also used as an additive in paints, textiles, and paper. 2-[(4-Chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutanamide is nonvolatile, nonflammable, and does not produce toxic byproducts when heated. This compound has low molecular weight with a molecular formula of C12H13NO5Cl. The structure of this compound includes two hydroxy groups (OH), one aliphatic hydrocarbon group (CH3), one carboxylic acid group (COOH), and three chlorine atoms (Cl). This product is soluble in water</p>

<p>5-Amino-2-methoxyisonicotinic acid is a carboxylic acid that is used in the synthesis of aminopyridines. The compound can be synthesized from formamidine acetate and diethyl dicarbonate. This process involves lithiation, followed by addition of an amine and finally conversion to the desired product with formamidine acetate. 5-Amino-2-methoxyisonicotinic acid can also be synthesized from formamide and diethyl ether. 5-Amino-2-methoxyisonicotinic acid is an analog of 2,4,6-trimethylaniline and has been shown to have similar properties to this compound, including strong basicity.</p>

<p>3,4-Diethoxybenzylalcohol is a metabolite produced by the fungus Ustilago maydis. It has been shown to have pleiotropic effects on the metabolism of the organism. 3,4-Diethoxybenzylalcohol is involved in lignin biosynthesis and bond cleavage reactions. In addition to functioning as an intermediate in the pentose phosphate pathway, it is involved in the nature of the basidiomycete cell wall and also plays a role in carbon source utilization.</p>

<p>Please enquire for more information about 3'-[2- Cyanoethyl N, N- bis(1- methylethyl) phosphoramidite]-5'- O- [bis(4- methoxyphenyl) phenylmethyl] - 2'- O- methyl- N- [2- [4- (1- methylethyl) phenoxy] acetyl] -guanosine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-Ethoxy-2-benzothiazolesulfonamide is a drug that inhibits carbonic anhydrase, which is an enzyme that catalyzes the conversion of carbon dioxide and water to bicarbonate and hydrogen ions. This drug has been shown to be effective for the treatment of bowel disease in animal models. 6-Ethoxy-2-benzothiazolesulfonamide has also been shown to have inhibitory properties against carbonic anhydrase, which may lead to problems with dehydration.</p>

<p>Please enquire for more information about 4-Acetylamino-5-bromo-2-methoxy-benzoic acid methylester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 8-Fluoro-6-methoxy moxifloxacin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Methoxytriethyleneglycol methacrylate is a biocompatible polymer that is used as an antimicrobial agent. It can be used to prevent microbial infection and can be incorporated into polymeric materials, such as microcapsules, to form a model system for the study of drug release kinetics. Methoxytriethyleneglycol methacrylate has shown anti-inflammatory properties in the presence of hydrogen bonds with growth factors and reactive oxygen species. The phosphotungstic acid residue in this molecule has been shown to have antimicrobial activity against several strains of bacteria, including Staphylococcus aureus and Escherichia coli.</p>

<p>Sildenafil is a drug that is used to treat erectile dysfunction. It inhibits the action of phosphodiesterase type 5 (PDE-5), an enzyme that breaks down the messenger cyclic guanosine monophosphate (cGMP) within the corpus cavernosum. This leads to increased levels of cGMP, which relaxes smooth muscle cells in the corpus cavernosum and allows for more blood flow into the penis. Sildenafil is synthesized from chrysanthemum morifolium, a plant also known as "shamrock." Sildenafil has been shown to have no effects on insulin resistance or lipid metabolism, but it does cause side effects such as headache, visual disturbances, and hearing loss.</p>

<p>Bosentan is a potent inhibitor of the uptake of organic anions. It is used in the treatment of pulmonary arterial hypertension and has been shown to be effective against pravastatin-resistant HIV protease inhibitors, such as saquinavir, quinidine, and rosuvastatin. Bosentan inhibits uptake by binding to the transporter protein at a site that does not overlap with the binding site for organic anion substrates. This leads to a change in kinetic parameters for substrates, such as pravastatin and saquinavir. The binding site on bosentan may also be elucidated through monolayer experiments with efflux transporters.</p>

<p>2-(2-Bromoethoxy)tetrahydro-2H-pyran is a synthetic molecule that has been shown to act as an estrogen receptor modulator, which has the potential to be used for the treatment of hormone-sensitive diseases such as breast cancer. This compound is chemically very similar to other compounds that have been shown to be effective in treating breast cancer. 2-(2-Bromoethoxy)tetrahydro-2H-pyran has a cavity and 6 hydroxyl groups that can form hydrogen bonds with water molecules, leading to its gelling properties. In addition, this compound is thermoreversible and can reversibly gel when heated or cooled. The gelation property of 2-(2-Bromoethoxy)tetrahydro-2H-pyran makes it a promising candidate for use in vaginal tablets, which could potentially lead to treatments for vaginal dryness and atrophy.</p>

<p>(S)-(-)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride is a synthetic chiral compound that is used to study the role of glyoxylate in biochemical reactions. This drug is an enolate and alkylating agent that can react with nucleophiles such as amines and thiols. It has been shown to be effective against perchlorates by hydrolyzing them into chlorine and oxygen gas. This drug has also been shown to inhibit the growth of Rhodobacter sphaeroides by inhibiting glyoxylate metabolism.</p>

<p>Please enquire for more information about 2,6-Difluoro-4-methoxyphenol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(2-Oxiranylmethoxy)benzeneethanol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3,4-Bis(1,1-dimethylethoxy)-3-cyclobutene-1,2-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(S)-HPMPA is a nucleotide analogue, which is a chemically synthesized compound designed to mimic nucleotides. It acts as both an antiviral and an antitumor agent, sourced primarily through synthetic chemistry involving the modification of naturally occurring nucleotide structures. The mode of action of (S)-HPMPA involves mimicking natural substrates of various viral polymerases and cellular enzymes, thereby inhibiting viral DNA synthesis and disrupting the replication cycle of DNA viruses. Additionally, it can interfere with certain cellular pathways contributing to its antitumor effects.</p>

<p>(R)(−)-DOI hydrochloride is a synthetic compound classified as a selective serotonin receptor agonist. It is primarily sourced from chemical synthesis processes designed to explore potential interactions within serotonergic pathways. The compound’s mode of action involves the activation of 5-HT2A, 5-HT2B, and 5-HT2C serotonin receptors, which play crucial roles in modulating neurotransmission and signaling pathways within the central nervous system.In research and experimental contexts, (R)(−)-DOI hydrochloride is utilized to investigate the molecular mechanisms of serotonin receptors, contributing to a deeper understanding of their role in neurophysiology and potential implications in neuropsychiatric disorders. Studies often explore its effects on cognition, perception, and mood regulation. Despite its promising role in scientific exploration, (R)(−)-DOI hydrochloride is not intended for therapeutic use and remains predominantly a tool for advancing the field of neuropharmacology through controlled experimental settings.</p>

<p>Please enquire for more information about 3-[2-Amino-3-(2-tert-butoxycarbonyl-ethoxy)-2-(2-tert-butoxycarbonyl-ethoxymethyl)-propoxy]-propionic acid tert-butyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (4S)-3,4-Dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazin-4-ol 1,1-dioxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Gly-arg-4-methoxy-beta-naphthylamide dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-(2-Fluoroethoxy)Propanenitrile is a chemical with toxic properties. It is classified as a fluoroacetic acid and has been used in the production of other chemicals. Fluoroacetic acid is toxic to humans, showing signs of skin irritation, respiratory tract irritation, and kidney damage. 3-(2-Fluoroethoxy)Propanenitrile is not found naturally and has been sponsored by many companies.</p>

<p>Please enquire for more information about Trifluoro(1,1,2,2-Tetrafluoro-2-Iodoethoxy)Ethylene including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Methoxy 17b-estradiol is a synthetic estrogen that binds to DNA and alters the transcriptional process. It has been shown to induce apoptosis by activating the pro-apoptotic protein Bax and inhibiting the anti-apoptotic protein Bcl-2. This drug inhibits the metabolic response of cancer cells to chemotherapy, leading to a decrease in tumor size, and can be used as an implantable device for treating cancer. 2-Methoxy 17b-estradiol also has minimal toxicity in comparison to other estrogens, with no significant cytotoxicity observed in cells of reproductive tissues or endocrine organs, nor any significant toxic effects on liver function tests or serum lipids.</p>

<p>Trans-2,5-dimethoxy-4'-nitrostilbene is a molecule that belongs to the class of polycyclic aromatic compounds. It is used as a versatile building block in organic synthesis, and is also an intermediate for the production of other compounds. Trans-2,5-dimethoxy-4'-nitrostilbene has been shown to be effective in the preparation of various pharmaceuticals such as diazepam and chloramphenicol. It is also used in research chemicals and speciality chemicals. The structure of trans-2,5-dimethoxy-4'-nitrostilbene can be described as a bicyclic compound with two phenyl rings joined by an oxygen bridge. Trans-2,5-dimethoxy-4'-nitrostilbene has CAS No. 552938 4 and molecular weight of 268.81 g/mol.</p>

<p>Applications 2-Hydroxy-4,6-dimethoxybenzoic acid is a reagent used in the synthesis of rac Zearalenone-d6 (Z270502). rac Zearalenone-d6 s an estrogenic mycotoxin produced by Fusarium fungi commonly found in grains. One of a group of compounds known as resorcylic acid lactones.<br>References Tanaka, T., et al.: J. Agric. Food Chem., 36, 979 (1988), Hamilton, S., et al.: Anticancer Res., 16, 3597 (1996), Hecht, S., et al.: Cancer Lett., 150, 49 (2000), Hussein, H., et al.: Toxicology, 167, 101 (2001), Lim, H., et al.: J. Immunol., 175, 4180 (2005),<br></p>