Amides

<p>Avanafil is a drug that can be used as a treatment for male erectile dysfunction. It works by inhibiting the production of PDE5, which is an enzyme that regulates the levels of cGMP in the penis. Avanafil has been shown to be effective when taken at a dose of 100 mg; this is because it takes about 30 minutes for avanafil to reach its peak level. Avanafil has a chemical stability that is greater than 12 hours, with an average lifespan of 24 hours. The drug also has no major drug interactions and does not inhibit any other drugs from working.</p>

2-(5-Bromo-1H-indol-3-yl)acetamide is a high quality, reagent, complex compound, useful intermediate and fine chemical. It is also a useful scaffold or building block for the synthesis of speciality chemicals. 2-(5-Bromo-1H-indol-3-yl)acetamide is used in research and development as a versatile building block for the synthesis of new compounds. The CAS number for this compound is 196081-79-5.

3-Cyanobenzamide is an organic compound with the formula CHC(N)NH. It is a white crystalline solid that can be obtained by reacting benzamide with cyanoacetylene. There are three possible isomers of 3-cyanobenzamide: 3-cyano-1-(substituted phenyl)benzamide, 3-cyano-2-(substituted phenyl)benzamide, and 3-cyano-3-(substituted phenyl)benzamide. The optimal reaction conditions for the synthesis of 3-cyanobenzamide are in the presence of hydrogen bonding, such as n-hexane, amide, and phase equilibrium. Studies have determined that 3-cyanobenzamide has the potential to cause cancer or liver toxicity in humans. In addition, this chemical has been shown to be an effective inhibitor of alpha glucosidase enzymes in vitro and in vivo.

<p>Morpholine-4-carboxamide is a polymerase chain inhibitor that inhibits the activity of DNA polymerases. It binds to the DNA template strand and prevents the enzyme from adding nucleotides to the primer strand, thereby inhibiting DNA synthesis. Morpholine-4-carboxamide has shown efficacy in treating hyperproliferative diseases such as cancer cells and psoriasis. This drug has been shown to inhibit caspase activation and histone protein acetylation, which may be related to its anti-cancer properties. Morpholine-4-carboxamide also binds to cannabinoid receptor 2 (CB2) and may have therapeutic effects on inflammatory diseases such as psoriasis and arthritis.</p>

<p>4-Hydroxy-3,5-dimethoxybenzamide is a phenolic compound that is soluble in organic solvents. It has been shown to bind to fatty acid sequences and neutral polypeptides in the presence of an acidic or basic environment. 4-Hydroxy-3,5-dimethoxybenzamide has also been shown to have catalytic activity, which may be due to its ability to form a polymeric matrix with other compounds.</p>

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<p>Rink amide-AM resin is a cation exchange resin that is used in peptide synthesis. It has an optimal pH range of 8-9. Rink amide-AM resin can be activated with trifluoroacetic acid or piperidine and washed with a mixture of water and methanol to remove the salt byproduct. The resin can then be used for peptide synthesis, which is typically done by adding the desired amino acids in sequence to the resin. The synthesis is stopped when the linear peptide reaches a desired length, typically 12-15 amino acids long. The linear peptides are then cleaved from the resin using trifluoroacetic acid or piperidine, depending on which activation reagent was used during synthesis. After cleavage, the linear peptides are precipitated from solution using ethanol or acetone and collected by filtration.</p>

Acetamide is an acyclic nucleoside phosphonate with a basic structure. Acetamide is metabolized to the corresponding ester hydrochloride, which has been shown to inhibit the polymerase chain reaction. This inhibition may be due to the effector proteins that are inactivated by acetamide, or it could be due to radiation-induced changes in the amide bond of the enzyme. Acetamide and its ester hydrochloride have been shown to inhibit skin cancer cells and carcinoma cell lines.

<p>Thioacetamide is a chemical compound that has been used as a model system to study apoptosis. It is also known to cause injury and biochemical changes in cells. Thioacetamide is metabolized by cytochrome P450 enzymes and conjugated with glucuronic acid, which prevents it from binding to DNA or protein. The oxidation of thioacetamide by cytochrome P450 enzymes leads to the formation of reactive oxygen species that may cause DNA damage. Apoptosis induced by thioacetamide has been shown to be mediated through the mitochondrial pathway, which involves the release of cytochrome C, activation of caspase-9, and cleavage of poly (ADP-ribose) polymerase (PARP). Thioacetamide also inhibits sorbitol dehydrogenase activity, which leads to an accumulation of sorbitol in cells. This accumulation can activate transcriptional factors such as nuclear factor kappa B (NF-κB), leading to</p>

<p>2,2'-(Diazene-1,2-diyl)bis(2-methylpropanimidamide) dihydrochloride (BPDC) is a synthetic compound that is used as an analytical reagent and a model system for oxidative injury. It has significant cytotoxicity on human cells in cell culture. BPDC induces oxidative damage to proteins and DNA by increasing the production of reactive oxygen species such as hydrogen peroxide, superoxide, and hydroxyl radicals. The mechanism of action is not well understood but may be due to Toll-like receptor signalling pathways. This compound has been shown to inhibit the activity of antioxidant enzymes such as glutathione peroxidase and catalase. It also inhibits the activity of proinflammatory cytokines such as IL-6 and IL-8. BPDC is being investigated for its potential use in bowel disease treatment.</p>

N-[2-Iodoethyl]trifluoroacetamide is a reactive alkylating agent that is used in the synthesis of biologically active molecules. It reacts with lysines, tryptic and other amino acids to form covalent bonds, which can be cleaved by hydrolysis. The compound also reacts with sulfhydryl groups to produce sulfonium ions, which react with the thiol group at position C6 on the sarcoplasmic reticulum Ca2+ -ATPase to inhibit muscle contraction. N-[2-Iodoethyl]trifluoroacetamide has been shown to cause allergic reactions in rats, mice, and guinea pigs. This drug has also been observed to have an effect on the central nervous system when administered at high doses.

<p>4-Benzylpiperazine-1-carboximidamide sulfate is a versatile building block that can be used in the synthesis of complex compounds. It is a useful intermediate that can be used in the production of research chemicals and speciality chemicals. 4-Benzylpiperazine-1-carboximidamide sulfate is also an excellent reagent for reactions involving complex substrates, such as high quality and useful scaffolds.</p>

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Benzoyl-L-tyrosine amide is a reaction intermediate that is a competitive inhibitor of serine proteases. It binds to the active site of the enzyme and inhibits the breakdown of proteins by blocking the access of other reactants. Benzoyl-L-tyrosine amide has been shown to inhibit proteolytic activity in subtilis, an enzyme isolated from Bacillus licheniformis. The amino acid composition and binding properties are similar to those found in natural substrates. Benzoyl-L-tyrosine amide has been synthesized and its binding affinity towards histidine residues has been determined by titration calorimetry and fluorophosphate assay.

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N-alpha-Benzoyl-L-arginine amide hydrochloride (BA) is a synthetic, noncompetitive inhibitor of phosphodiesterase. It has been shown to inhibit protease activity in vitro and rhizosphere enzyme activities in vivo. BA also inhibits the formation of hippuric acid from benzoic acid, which is a reaction catalyzed by the enzyme phosphatase. The kinetics of this inhibition have been studied using a number of different substrates and enzymes. BA binds to the catalytic site on the enzyme, sterically hindering binding of the substrate and preventing hydrolysis.

<p>AZD 1152 is an Aurora kinase inhibitor, which is a type of small-molecule therapeutic agent. It is derived from the pharmaceutical research conducted by AstraZeneca. Its primary mode of action involves the selective inhibition of Aurora B kinase, an enzyme crucial for the regulation of mitosis. By interfering with this enzyme, AZD 1152 disrupts the normal progression of cell division, leading to the inhibition of proliferation and induction of apoptosis in rapidly dividing cells.</p>

Labetalol is a β-blocker that is used to treat high blood pressure. Labetalol hydrochloride, the active form of labetalol, is a white, crystalline compound with a melting point of 200 °C. It is soluble in water and has an acidic pH of 2. Labetalol hydrochloride is synthesized by reacting methylbenzene with labetalol, which forms intermediates such as methyl 4-hydroxylbenzoate and methyl 3-hydroxylbenzoate in the process. The intermediates are then recrystallized to form the final product. Labetalol hydrochloride undergoes thermal analysis using thermogravimetry, calorimetry, and residue analysis to determine its purity. This product also undergoes carbonaceous and oxidative analysis by GC-MS for quality control purposes.

Eliglustat is an oral medication used as a substrate reduction therapy for Gaucher disease type 1, which is an inherited lysosomal storage disorder. This product is a small-molecule inhibitor derived via chemical synthesis. Its primary mode of action involves the selective inhibition of glucosylceramide synthase, an enzyme responsible for the first committed step in glycosphingolipid biosynthesis. By reducing the production of glucosylceramide, eliglustat decreases the substrate accumulation that contributes to the pathophysiology of Gaucher disease.

Please enquire for more information about (3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl)-N-(2-indol-3-ylethyl)formamide including the price, delivery time and more detailed product information at the technical inquiry form on this page