Amides

<p>Applications N-(4-Chlorophenyl)-2,6-Difluorobenzamide (cas# 122987-01-3) is a useful research chemical.<br></p>

<p>Impurity Atenolol EP Impurity A<br>Applications 4-(Hydroxyphenyl)acetamide (Atenolol EP Impurity A) is used as an intermediate for the synthesis of Atenolol (A790075) and various other organic compounds and pharmaceuticals. It is a process impurity for Atenolol (A790075)<br>References Inkum, R., et al.: Maejo Int. J. Sci. Tech., 6, 372 (2012); Pai, N.R., et al.: J. Chem. Pharma. Rsch., 4, 375 (2012); Moon, J.T., et al.: Bio-org. Medn. Chem., 20, 734 (2012);<br></p>

<p>Applications N-(3-(Dimethylamino)propyl)dodecanamide is used in the study of surface chemistry and colloids as a new surfactnt for hydrate anti-agglomeration in hydrocarbon flowlines and seabed oil capture.<br>References Sun, Minwei, Journal of Colloid and Interface Science, 402, 312-319, (2013)<br></p>

<p>Applications 2-Amino-N-benzylbenzamide can be used for drug discovery and pharmaceutical manufacturing.<br>References Amini-Rentsch, L., et.al., Ind. Eng. Chem. Res., 58, 10164-10171, (2019);<br></p>

<p>Applications N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide (cas# 10558-45-9) is a useful research chemical.<br></p>

<p>Applications N-{2-[(4-Hydroxyphenyl)sulfanyl]ethyl}acetamide (cas# 91281-32-2) is a useful compound for use as a skin-lightening agent; cosmetic applications.<br>References Parvez, S., et al.: Phytother. Res., 20, 921 (2006)<br></p>

<p>Applications tert-Butylsulfinamide can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. tert-Butylsulfinamide is also used as a reagent in the synthetic preparation of amide series as BACE1 inhibitor and potential anti-Alzheimer’s drug.<br>References Szallasi, A., et al.: Pharmacol. Rev., 51, 159 (1999), Montell, C., et al.: Mol. Cell., 9, 229 (2002), Ryu, C., et al.: Bioorg. Med. Chem. Lett., 14, 1751 (2004), Suh, Y., et al.: J. Med. Chem., 48, 5823 (2005); Woltering, T. J., et al.: Bioorg. Med. Chem. Lett., 23, 4239 (2013)<br></p>

<p>Applications N-BENZYLBENZAMIDE (cas# 1485-70-7) is a useful research chemical.<br></p>

<p>Applications N-Acetyl-N-(phenylmethyl)-propanamide is an intermediate in the synthesis of N-Ethyl-N-nitroso-1-propanamine-d4 (E817997) and isotope labelled version of N-Ethyl-N-nitroso-1-propanamine. N-Ethyl-N-nitroso-1-propanamine is a derivative of N-Nitrosodiethylamine (N525465),a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.<br>References Shirakami, Y., et al.: Bitamin, 87, 156 (2013); Fujii, Y., et al.: Toxicol., 305, 30 (2013); Uehara, T., et al.: Toxicol. Sci., 132, 53 (2013);<br></p>

<p>Applications 2,3-Dihydroxybenzamide is a disubstituted benzamide used in the preparation of a catechol metabolite of dilevalol. 2,3-Dihydroxybenzamide is also used in the preparation of iron chelating agents.<br>References Tulshian, D.D. et al.: Bioorg. Med. Chem. Lett., 3, 2073 (1993); White, G.P. et al.: Brit. J. Haematol., 33, 487 (1976);<br></p>

<p>Applications N-allyl-2-chloro-acetamide (cas# 13269-97-1) is a useful research chemical.<br></p>

<p>Applications 2-Isobutyryl-N-phenyl-3-phenylacrylamide is the labeled analogue of 2-Isobutyryl-N-phenyl-3-phenylacrylamide (I781040), an intermediate for the synthesis of Atorvastatin-d5 Sodium Salt (A791753), the labeled analogue of Atorvastatin (A791750) (1,2,3). Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993) (2) Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996) (3) Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)<br></p>

<p>Applications N-Cyclopropyl 5-bromonicotinamide<br></p>

<p>Applications 2-Hydroxy-5-nitrobenzamide is used in the synthesis of salicylamides and its nitro derivatives.<br>References Gupta, G. L.: J. Proc. Inst. Chem., 38, 165 (1966)<br></p>

<p>Applications 2-Amino-N,N-dimethylbenzenesulfonamide is an intermediate used to prepare LDK378 as potent and selective anaplastic lymphoma kinase inhibitor.<br>References Marsilje, T., et al.: J. Med. Chem., 56, 5675 (2013)<br></p>

<p>Stability Not stable in Strong Base<br>Applications 3-Hydroxyisothiazole-5-carboxylate (cas# 62020-63-7) is a compound useful in organic synthesis.<br></p>

<p>Applications N-(4-Bromo-2-picolinoylphenyl)-2-chloroacetamide is a derivative of 2-(2-Amino-5-bromobenzoyl)pyridine (A601785); an intermediate in the preparation of Bromazepam (B678500).<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998); El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001); Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005)<br></p>

<p>Applications Used in the preparation of antifungal agents.<br>References Del Poeta, M. et al.; Antimicrob. Agents Ch., 42, 2495 (1998)<br></p>

<p>Applications Methanesulfonamide is used in biological studies to predict binding affinity and binding mode of protein ligand complexes.<br>References Raha, K., et al.: J. Med. Chem., 48, 4558 (2005)<br></p>

<p>Applications exo-2,3-Norbornanedicarboxylic Acid Monoamide is an impurity in the synthesis of Lurasidone (L474920) an antipsychotic used for treatment of schizophrenia.<br>References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007), Cole, P., et al.: Drugs of the Fut., 33, 316 (2008),<br></p>

<p>Applications 5-Amino-2-chlorobenzenesulfonamide (cas# 2015-19-2) is a compound useful in organic synthesis.<br>References Somers, F., et al.: Pharm. Pharmacol. Commun., 6, 89 (2000), D'Ambrosio, K., et al.: J. Med. Chem., 51, 3230 (2008),<br></p>

<p>Applications 2-(2-hydroxyphenyl)acetamide (cas# 22446-40-8) is a useful research chemical.<br></p>

<p>Applications N-(2-(1,3-Dioxoisoindolin-2-yl)ethoxy)benzamide is an intermediate in the synthesis of Fluvoxamine Maleate (F603500), a selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.<br>References Claassen, V., et al.: Br. J. Pharmacol., 60, 505 (1977); Koran, L.M., et al.: J. Clin. Psychopharmacol., 16, 121 (1996); Ware, M.R., et al.: J. Clin. Psychiatry, 58, Suppl. 5, 15 (1997); Inazu, M., et al.: Neurochem. Int., 39, 39 (2001)<br></p>

<p>Applications N-Isobutylsorbamide shows antitubercular activity towards mycobacterium strains. It is a derivative of Sorbic Acid (S676890), a naturally occurring organic compound first isolated from unripe berries and used as a food preservative and as an inhibitor of Clostridium Botulinum bacteria in meat products.<br>References Gupta, O. et al.: Bull. Med. Ethno-Bot. Res., 1, 99 (1980); Van, M.C., et al.: Int. J. Food. Microbiol., 160, 124 (2012); Li, J., et al.: J. Am. Soc. Mass. Spec., 23, 1625 (2012);<br></p>

<p>Applications N-(2-aminoethyl)benzamide (cas# 1009-17-2) is a useful research chemical.<br></p>

<p>Applications N,N-Diethyl-p-toluamide, is a buildig block used in the synthesis of phthalocyanines. It can also be used in preparation of new insect repellents.<br>References Liang, J., et al.: Nongyaoxue Xuebao, Vol. 16,P: 644-650 (2014);<br></p>

<p>Applications 3,5-Di-tert-butyl-4-hydroxybenzamide is used in the preparation of 2-(3,5-di-tert-butyl-4-hydroxyphenyl)oxazoles as anti-atherosclerotic agents.<br>References Steinberg, et al.: Am. J. Cardiology, 57, 16 (1986), Reaven, et al.: Arteriosclerosis and Thrombosis, 12, 318 (1992),<br></p>

<p>Applications Tosyl Brinzolamide is a derivative of Brinzolamide (B677601) which is a carbonic anhydrase inhibitor and an antiglaucoma agent.<br>References Silver, L.H., et al.: Am. J. Ophthalmol., 126, 400 (1998);Davies, N., et al.: Clin. Exp. Pharmacol. Physiol., 27, 558 (2000); Stave, J., et al.: Ophthalmologe, 99, 276 (2002);<br></p>

<p>Applications 4-Nitrobenzenesulfonamide (cas# 6325-93-5) is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of nitro substituted quinazolones.<br>References Tobe, M., et al.: Bioorg. Med. Chem., 11, 3869 (2003), Chinigo, G., et al.: J. Med. Chem., 51, 4620 (2008),<br></p>

<p>Applications N-(1-Chloro-2-oxo-2-phenylethyl)benzamide is an amidophenacylating reagent used in various organic reactions, e.g. in the synthesis of thiohydantoin derivatives.<br>References Balya, A.G., et al.: Russ. J. Gen. Chem., 78, 1427 (2008); Belyuga, A.G., et al.: Zhurnal Organichnoi ta Farmatsevtichnoi Khimii, 2, 25 (2004)<br></p>

<p>Applications N-(3-Morpholinopropyl)-2-(p-tolyl)benzo[d]imidazo[2,1-b]thiazole-7-carboxamide is a useful synthetic intermediate in organic synthesis and pharmaceuticals.<br></p>