Amides

<p>2-Amino-4-methylthiophene-3-carboxamide is a small molecule that is a potent inhibitor of the JAK2 kinase. This enzyme is associated with human fibrosis and has been shown to be involved in the development of liver fibrosis in rats. 2-Amino-4-methylthiophene-3-carboxamide inhibits the production of cytokines such as IL1α, IL6, and TNFα. It also blocks the activation of transcription factors such as NFκB, which are involved in inflammation. The compound has been shown to be orally active and has demonstrated efficacy in animal studies. Analogues have also been synthesized for this compound that show similar activity.</p>

<p>N-(2-Piperidin-4-ylethyl)methanesulfonamide hydrochloride (MSM) is a fine chemical that belongs to the group of useful scaffolds. It is used as a versatile building block in research and can be used as a reaction component for speciality chemicals. The compound has high quality and can be used as a reagent, which is an important tool for organic synthesis.</p>

<p>3,4-Dichlorobenzamide is a synthetic opioid analgesic that binds to the μ-opioid receptor. It has a side-effect profile that is similar to other opioids, with an addiction risk and potential for abuse. 3,4-Dichlorobenzamide has been used in the synthesis of new drugs, such as phenazepam (a benzodiazepine) and etizolam (a thienodiazepine). This drug is chiral and can be synthesized in two stereoisomeric forms: 3-(+)-chloro-N-(2-chlorophenyl)benzamide and 3-(−)-chloro-N-(2-chlorophenyl)benzamide. The former form is marketed under the trade name Analgin, while the latter form is marketed under the trade name Etilex. The (+) form of this drug has a higher affinity for μ receptors than the (−) form.</p>

<p>3,5-Dinitrobenzamide is a sulfa drug that inhibits the growth of bacteria by inhibiting 3-dehydroquinate synthase (EC 4.2.1.23) and 3-dehydroquinate dehydratase (EC 4.2.1.46). The enzyme catalyzes the conversion of 3-dehydroquinic acid to quinic acid, which is an intermediate in the biosynthesis of benzoic acid from glucose. This inhibition occurs because 3,5-dinitrobenzamide forms a glycosidic bond with Cys34 in these enzymes, which prevents their function. This drug has been shown to have significant cytotoxicity against human pathogens and model organisms such as Salmonella typhimurium and Escherichia coli, but not against Saccharomyces cerevisiae or Candida albicans.</p>

<p>Bifenthrin is a broad-spectrum, synthetic pyrethroid insecticide that has been used to control pests in the agricultural and residential sectors. It is applied as a spray or dust on plants and animals. Bifenthrin is highly toxic to mammals, with an oral LD50 of less than 10 milligrams per kilogram of body weight in rats and mice. The acute toxicity can be attributed to its ability to inhibit protein synthesis by binding to the cholinesterases, which are found in high concentrations in mammalian tissues.</p>

<p>N-(2,6-Dimethylphenyl)-1-piperazineacetamide is a byproduct of solvents and stabilizers. It has been found to be a crystalline solid with a molecular weight of 233.3 g/mol. The crystal structure was determined and found to be composed of two molecules of acetamide that are connected through hydrogen bonds. N-(2,6-Dimethylphenyl)-1-piperazineacetamide is soluble in ethanol and ether, but insoluble in water. This compound interacts with other substances, such as recrystallizing or substituting acetamides.</p>

<p>Non-steroidal androgen receptor antagonist</p>

<p>Rink amide PEGA resin is a cation-exchange resin that has been modified with poly(ethylene glycol) and poly(ethylene oxide). It binds to calcium ions, which are required for cell division. Activated resins can be used in animal diagnostic tests to measure blood glucose levels or as an adsorbent for the removal of heavy metals from drinking water. Rink amide PEGA resin can be used to modify polymer conjugates and assay biological properties, such as cancer cells or solid-phase synthesis.</p>

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<p>N-(Phenylsulfonyl)palmitamide is a versatile building block that can be used to create complex compounds for research. CAS No. is 527-87-2 and it is a reagent and speciality chemical with high quality. It is also useful as a reaction component in the synthesis of other compounds, or as a scaffold for the synthesis of new derivatives.</p>

<p>N,3-Diphenylacrylamide is an amide that has been shown to exhibit carcinoid syndrome in humans. It also inhibits the growth of some human pathogens, including viruses and bacteria, as well as some fungi. The compound is metabolized by a number of enzymes and can be found circulating in the blood. Magnetic resonance spectroscopy has been used to study the structure of this molecule, which is composed of a carbonyl group and hydrogen bond. The effective dose for N,3-Diphenylacrylamide is not known.</p>

<p>Homoveratramide is a synthetic drug that is used as an antibacterial agent. It has a broad spectrum of activity against bacteria, fungi, and protozoa. Homoveratramide has been shown to be effective against both Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Homoveratramide inhibits the synthesis of DNA by binding to the enzyme ribonucleotide reductase. This produces a bacteriostatic effect on the cell by halting DNA replication and transcription.</p>

<p>4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide is an amide that is used to treat HIV infections. It has been shown to have potent anti-viral activity against HIV infected cells in the laboratory and can inhibit the replication of HIV by interfering with the virus's ability to use the reverse transcriptase enzyme. 4ABAB has been shown to bind to the enzyme ribonuclease H (crth2), which is responsible for breaking down viral RNA. This binding prevents crth2 from cleaving viral RNA, thus inhibiting DNA synthesis and preventing cell death. 4ABAB also interferes with a hydrogen bond between ethyl group and the hydroxyl group on crth2, leading to a decrease in activity.</p>

<p>3-Aminobenzamide is a drug that has been shown to be effective in the treatment of temozolomide-induced neuronal death. 3-Aminobenzamide inhibits the synthesis of ATP and blocks its binding to the atp-binding cassette transporter, which prevents the transport of this nucleotide into cells. This results in cell death due to insufficient energy metabolism and inability to repair DNA damage. 3-Aminobenzamide also increases production of reactive oxygen species, which are involved in reperfusion injury and myocardial infarcts. 3-Aminobenzamide is used as a model system for studying DNA repair and energy metabolism.</p>

L-Aspartic acid beta-naphthylamide is a dietary amino acid that is metabolized to oxaloacetate in the liver. This metabolite is then converted to aspartate and glutamate, which are both important for brain functions. L-Aspartic acid beta-naphthylamide has been shown to have regulatory effects on peptide hormones, such as inhibiting the synthesis of angiotensin II and vasopressin in rats. L-Aspartic acid beta-naphthylamide also has anti-cancer properties, which may be due to its ability to inhibit the growth of cancer cells by hydrolyzing proteins and enzymes involved in fatty acid synthesis.

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<p>N-[2-Iodoethyl]trifluoroacetamide is a reactive alkylating agent that is used in the synthesis of biologically active molecules. It reacts with lysines, tryptic and other amino acids to form covalent bonds, which can be cleaved by hydrolysis. The compound also reacts with sulfhydryl groups to produce sulfonium ions, which react with the thiol group at position C6 on the sarcoplasmic reticulum Ca2+ -ATPase to inhibit muscle contraction. N-[2-Iodoethyl]trifluoroacetamide has been shown to cause allergic reactions in rats, mice, and guinea pigs. This drug has also been observed to have an effect on the central nervous system when administered at high doses.</p>

<p>Chemically a chlorinated salicylanilide, niclosamide is clinically used as an anthelmintic agent. The action of niclosamide has been proven to proceed by inhibiting the STAT3 signaling pathway. Recently, niclosamide, has been considered as an antiproliferative agent in cancer treatment, e.g. melanoma and colorectal cancer. In 2021, niclosamide has been tested for the treatment of COVID-19 patients.</p>

<p>2-Chloro-N-(4-chlorophenyl)acetamide (2CPA) is an antimycobacterial agent that inhibits the growth of Mycobacterium tuberculosis. The antimycobacterial activity of 2CPA has been demonstrated in a dilution method, where it reduced the number of viable cells in cultures of M. tuberculosis and Mycobacterium smegmatis. The antimicrobial activity of 2CPA was confirmed using a fluorescence assay, which showed that this compound is active against M. tuberculosis H37Rv and M. smegmatis at concentrations above 0.1 mM. 2CPA also has a potent bactericidal effect on Staphylococcus aureus with an MIC value of 0.06 mg/mL at 30 minutes and is active against Enterococcus faecalis with an MIC value of 4 mg/mL at 30 minutes.</p>

<p>Phenylmethanesulfonamide is a chemical compound that has been shown to inhibit the proliferation of cancer cells in vitro. This drug has also been shown to be effective in reducing inflammatory diseases, such as arthritis and asthma, which may be due to its ability to inhibit prostaglandin synthesis. Phenylmethanesulfonamide has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>2,2,2-Trifluoroacetamide is a chemical compound that is stable under normal conditions and can be stored for long periods of time. The compound has been shown to react with trifluoroacetic acid and in the presence of an electrochemical probe to give a redox reaction. This reaction mechanism has been studied by using pharmacokinetic properties of 2,2,2-trifluoroacetamide and its metabolites. The compound is not active against infectious diseases but may be used as a reagent in analytical methods. 2,2,2-Trifluoroacetamide has also been investigated for its ability to bind hydrogen atoms and form intramolecular hydrogen bonds with tryptophan residues in proteins.</p>

<p>Clofenamide is a drug that is used to treat insulin resistance. It is an at1 receptor antagonist that blocks the action of histamine, which stimulates the release of insulin from the pancreas. Clofenamide has been shown to reduce systolic blood pressure in patients with autoimmune diseases and cardiac hypertrophy. It is also used for treating infectious diseases, such as pneumonia and tuberculosis. Clofenamide reduces inflammation by inhibiting inflammatory enzymes, such as butyric acid. This drug has been found to have anticancer activity in cell-based studies by inhibiting cellular proliferation and inducing apoptosis in cancer cells.</p>

<p>4-Chloro-3-nitrophenylacetamide is a chemical compound that can be used as a reagent, useful scaffold for research, and a high quality research chemical. CAS No. 5540-60-3, this versatile building block is useful for the synthesis of complex compounds and fine chemicals.</p>

<p>4-Cyanobenzamide is a naphthalene derivative that is both reactive and intramolecular. It has been shown to react with the amino group of peptides, forming a ruthenium complex. The functional groups are acceptors and donors that can be used in assays for the detection of anions or cations. 4-Cyanobenzamide reacts with water to release hydrogen gas, which can be used to measure its hydration ability. This compound has been synthesized using solid-phase synthesis and it has amide bonds that vibrate at a specific frequency.</p>

<p>(+/-)-tert-Butylsulphonamide is a synthetic molecule that is a functional group with two aryl halides. It has been shown to inhibit the mitochondrial protein synthesis by preventing the nitrosylation of tyrosine residues in proteins. This inhibition prevents the production of growth factors and other bioactive molecules, leading to an increase in the cell's sensitivity to genotoxic agents. (+/-)-tert-Butylsulphonamide has also been shown to inhibit viral replication and infectivity by targeting viral RNA polymerase, which is responsible for viral transcription. The chloride anion present in (+/-)-tert-butylsulphonamide may have an inhibitory effect on viruses with a low pH environment, such as naphthalene or carbonic acid; however, it does not affect viruses with a neutral pH.END&gt;</p>

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