Amides

<p>Beta-alanine amide HCl is a research chemical that belongs to the class of beta-amino acid derivatives. Beta-alanine amide HCl is an activator of nucleophiles and can be used in analytical chemistry as an indicator for chloride ions. It has been shown to react with asparagine, yielding beta-alanine and ammonia. The reaction system can be analysed by measuring the elimination of a hydrogen chloride ion from the beta-alanine amide HCl molecule and the subsequent increase in pH. The analytical method has also been used to measure concentrations of deamination reactions and redox potentials at high concentrations.</p>

<p>L-Serine amide hydrochloride is a synthetic, anti-HIV drug that is used as an antiviral agent. It inhibits the viral life cycle by inhibiting the activity of acyclic nucleoside phosphonates, which are vital to viral DNA synthesis. L-Serine amide hydrochloride binds to the cyclopentane ring of guanosine and prevents its interaction with the enzyme ribonucleotide reductase. This binding prevents the conversion of guanosine into GTP, thereby preventing HIV from using this molecule in their life cycle. L-Serine amide hydrochloride is not active against cellular proteins or prostaglandins.</p>

<p>N'-Hydroxycyclopropanecarboximidamide (N-HCPC) is an alkoxycarbonyl-containing heterocycle that is structurally related to the benzodiazepine class of drugs. It has been shown to have depressant activity in animal models and may be useful as a treatment for epilepsy, but it also has psychoactive properties. N-HCPC can cause epileptic seizures in humans, although this effect appears to be dose dependent. It may also have potential use as a treatment for Alzheimer's disease and depression due to its ability to bind to the benzodiazepine receptor. The drug binds with high affinity to muscle tissue, which may explain its effects on muscle control and movement.</p>

<p>N-Bromoacetamide is a reactive chemical that can react with the sodium channel to produce a postulated effect. It has been shown to inhibit the kinetics of the sodium channel in whole-cell voltage clamp experiments. This inhibition is reversible and does not depend on the pH of the solution. Bromoacetamide has been shown to have an irreversible inhibition on potassium channels, which may be due to its ability to form covalent bonds with sulfhydryl groups. Bromoacetamide also inhibits voltage-gated calcium channels, but at a slower rate than it does for sodium channels. N-Bromoacetamide has been shown to be effective in pharmacological treatments for epilepsy, myasthenia gravis, and multiple sclerosis.</p>

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<p>Oxamide is a chemical compound with the molecular formula CHNO. It is a white solid that is moderately soluble in water and alcohol, but not in ether. Oxamide has been shown to have antioxidative properties and to inhibit the formation of reactive oxygen species. This drug also has an effect on thermal expansion and on the blood flow rate in human serum.</p>

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N-Phenylpropanamide is a chemical inhibitor that has been shown to have a protective effect against the light-induced degradation of drugs in urine samples. The compound also inhibits the hydrolysis of amides by hydrochloric acid and hydrogen bonds with the receptor binding site on human liver cells. N-Phenylpropanamide has been shown to affect cardiac function, as well as growth factor production.

<p>N-[4-(1-Allyl-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)phenyl]acetamide (NUAA) is an antiinfective agent that has been shown to be effective against typhimurium. It inhibits bacterial growth by binding to the light chain of the monoclonal antibodies. NUAA is also able to inhibit uptake of iron in E. coli K12 and human cells. The mechanism for this inhibition is not well understood but may be related to its ability to bind iron homeostasis proteins or its oxidation catalyst activity.</p>

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<p>N-Acetylglycinamide is an amide that is structurally similar to the amino acid glycine. It has been shown to have anti-inflammatory properties by inhibiting prostaglandin synthesis in vitro. In vivo, N-acetylglycinamide is metabolized and excreted as the non-polar solvents n-acetylglycine and chloride. This amide is soluble in non-polar solvents such as chloroform, dichloromethane, or ether. N-acetylglycinamide also has a pairwise orientational order with respect to solvent molecules and exhibits a low degree of hydrogen bonding interactions with water molecules.</p>

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<p>L-Phenylalanine b-naphthylamide is a phenylalanine derivative that can be used as an indicator for the detection of Clostridium, 2-naphthylamine, and other anaerobes. This compound is a chromogenic substrate that reacts with amino groups in amino acids and amides in peptides to form a variety of color products. The condensation of phenylalanine with 2-naphthylamine is catalyzed by enzymes found in clostridia. When L-phenylalanine b-naphthylamide is incubated with tissue from animals or humans, it produces a pink coloration that indicates the presence of clostridia. The aerobic conditions necessary for this reaction are also found in the environment and within the body.</p>

<p>2-Oxo-3-hydroxy-N-methyl-N-propyl D-lysergamide (2OMD) is a metabolite of the drug lysergic acid diethylamide (LSD). It can be detected in urine, blood, and saliva. The detection time in urine is approximately 3 hours after ingestion. 2OMD can be found by chromatography techniques, such as thin layer chromatography or high performance liquid chromatography. It can also be detected using mass spectrometric techniques, such as gas chromatography/mass spectrometry or liquid chromatography/mass spectrometry. 2OMD can also be detected in urine samples by calibrations with standards of known concentration and by the use of analytical methods such as gas chromatography/mass spectroscopy.</p>

N-Cyanobenzenecarboximidamide hydrochloride (NCBCH) is an intermediate for the synthesis of azomethine dyes. It can be used to produce azo dyes with a methoxy group at the 3 position and a hydrogen atom at the 4 position. NCBCH is also an excellent substrate for chemical reactions involving fragmentation, extraction, or elimination. NCBCH can be synthesized from methyl ether and benzonitrile in the presence of benzamidine. The product is then treated with methanol to give a tautomeric mixture of benzyl and methyl ether.

<p>2-Chloro-N-(2-oxotetrahydro-3-thienyl)acetamide is a chemical compound that is used as an intermediate in the synthesis of other organic compounds. The impurities are minimized by using organic solvents such as acetone, pyridine, and tetrahydrofuran. The product can be precipitated by adding sodium carbonate or potassium carbonate to the solution, or it can be crystallized from a mixture of methanol and water. 2-Chloro-N-(2-oxotetrahydro-3-thienyl)acetamide is also soluble in ethers such as erdosteine and acetonitrile, which can be used to remove the last traces of water.</p>

<p>3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide (AMIS) is an intermediate in the preparation of medicaments. It is a stable process and can be used as an intermediate for other compounds. AMIS is prepared by reacting methanesulfonic acid with methanol and ammonium carbonate, which produces methanesulfonamide, succinic acid and ammonium hydroxide. The reaction liquid is then heated to produce a crystalline solid. The crystals are then recrystallized to yield AMIS as a white solid.</p>