Carboxylic Acids

<p>Applications 3,4-Dimethyl-3-cyclopentene-1-carboxylic Acid is a useful intermediate for organic synthesis.<br>References Otake, K., et al.: Chem. Pharm. Bull., 63, 998 (2015); Bartlett, P. D., et al.: J. Am. Chem. Soc., 87, 1297 (1965)<br></p>

<p>Stability Hygroscopic<br>Applications 4-Benzyl-morpholine-2-carboxylic is used in the synthesis of novel morpholine conjugated benzophenone analogs and evaluation of antagonistic role against neoplastic development.<br>References Al-Ghorbani, Mohammed. et al., Bioorg. Chem. 71, 55-66(2017);<br></p>

<p>Applications 4-​Chloro-​3-​sulfobenzoic acid is a useful chemical for the preparation of pyridinylbiphenylcarboxamide derivatives for the use as nervous system agents.<br>References Wei, Z.L., et al.: PCT Int. Appl. 199pp. Patent 2009 CODEN:PIXXD2;<br></p>

<p>Applications (2S)-2-acetamido-5-(diaminomethylideneamino)pentanoic Acid (cas# 155-84-0) is a useful research chemical.<br></p>

<p>Applications 5-Formylfuran-2-boronic Acid Pinacol Ester could be useful for the diastereoselective synthesis of cyclic peptide macrocycles via Petasis borono-Mannich reaction<br>References Yamaguchi, A., et al.: Chem. Commun. (Cambridge, U. K.), 55, 10567 (2019)<br></p>

<p>Applications tert-Butyl 2-(diethylphosphono)acetate is a chemical reagent used in the synthesis of pharmaceuticals such as Clopidogrel (C587250), s prodrug anticoagulant.<br>References Shaw, S. et al.: J. Org. Chem., 80, 7019 (2015);<br></p>

<p>Applications 2-Phenoxypropionic Acid is used in organic chemistry reduction reactions. Used in the synthesis of PPAR (peroxisome proliferator-activated receptor (PPAR) ligands.<br>References Brown, P. et al.: Synthesis., 7, 778 (1997);<br></p>

<p>Applications m-Tolylacetic acid is used as a reactant in the diastereoselective preparation of arylmethylene-isoindolinones.<br>References Anamimoghadam, Ommid, et al.: Beilstein J. of Org. Chem., 13, 2833-2841 (2017)<br></p>

<p>Applications Methyl Dimethylbenzeneacetate (cas# 57625-74-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 4-Oxo-5-hexanoic Acid Ester is used in the synthesis of analogs of 5-aminolevulinic acid (ALA), which are potential inhibitors of ALA dehydratase (porphobilinogen synthase), an early enzyme of tetrapyrrole biosynthesis;Also, it is an intermediate of 4-Oxo-6-(2-oxo-5-vinylpyrrolidin-1-yl)hexanoic Acid (O858780), which is derived from Ethyl Succinoyl Chloride (E818230), which is used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones. Vigabatrin Impurity 2<br>References Appleton, D., et al.: J. Chem. Soc., Perkin Trans., 89-101 (1998); Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012)<br></p>

<p>Applications 9-Hydroxydecanoic Acid is an intermediate in the synthesis of Monocarboxyisodecyl Phthalate (M525575), a metabolite of Dibutyl phthalate (DBP) (D429495), which is found widely in consumer products.<br>References Weber, A. E., et al.: J. Med. Chem., 35, 3755 (1992);<br></p>

<p>Applications 2-Acetylthioisobutyric Acid (cas# 135937-96-1) is a compound useful in organic synthesis.<br>References Souers, A., et al.: Bioorg. Med. Chem. Lett., 8, 2297 (1998), Deaton, D., et al.: Bioorg. Med. Chem. Lett., 18, 732 (2008),<br></p>

<p>Applications Useful in the preparation of substances with antiinflammatory activity.<br></p>

<p>Applications 2,2-Diethylhexanoic Acid is a pollutant that is found in anaerobic environment of river sediments,<br>References Chau, H., et al.: Appl. Biochem. Biotechnol., 70, 853 (1998); McInerney, M., et al.: Appl. Env. Microbiol., 41, 1029 (1981)<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester<br></p>

<p>Applications 4,5-dimethylthiophene-3-carboxylic acid (cas# 19156-52-6) is a useful research chemical.<br></p>

<p>Applications 4-Oxooctanoic Acid is one of mid-chain oxocarboxylic acids detected in Antarctic aerosols and possible precursors to the production of low molecular weight diacids such as succinic acid.Also, it is derived from 4-Octanolide (O239723), which is one of the fine organic aerosol emitted from meat cooking operations that was examined by high-resolution gas chromatography.<br>References Nishikiori, M., et al.: Chikyu Kagaku, 30, 27-34 (1996); Rogge, W., et al.: Environ. Sci. Technol., 25, 1112 (1992)<br></p>

<p>Stability Light Sensitive<br>Applications Ethyl 1-Bromocyclobutanecarboxylate is a reactant in the preparation of aroylindole-substituted phenoxyacetic acid derivatives, which has PPARγ and PPARα agonist activity, pharmacokinetics, and glucose and triglyceride lowering properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, W., et al.: J. Med. Chem., 52, 14 (2009)<br></p>

<p>Applications 2-​Hydroxy-​3-​phenyl-​acrylic Acid is a chemical reagent in the synthesis of an atropos biphenyl biphosphine ligand as well as in the synthesis of novel cinnamanilides as potential immunosuppressive agents.<br>References Shi, L. et al.: Eur. J. Med. Chem., 47, 585 (2012);<br></p>

<p>Applications 6-Acrylamidohexanoic Acid is a useful research chemical for organic synthesis and other chemical processes.<br>References Yamada, K., et al.: Tetrahedron Lett., 36, 9493 (1995); Park, W. K. C., et al.: Methods Enzymol., 242, 294 (1994); Nishimura, S., et al.: Tetrahedron Lett., 35, 5657 (1994)<br></p>

<p>Stability Moisture Sensitive<br>Applications Propylphosphonic Anhydride is used to prepare aryloxybenzylmorpholines as dual serotonin and noradrenaline reuptake inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fish, P., et al.: Bioorg. Med. Chem. Lett., 18, 2562 (2008)<br></p>

<p>Applications A reagent used in the synthesis of glycidol, a stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br>References Palomo, J.M. et al.: Tetrahedron Asymm., 16, 869 (2005); Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981); Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984);<br></p>

<p>Applications 4-Hydroxy-3,5-dimethylbenzoic Acid is used in the synthesis of Mexiletine (M340800) derivatives as orally bioavailable inhibitors. Also, used as a chemical reagent in the preparation of potent transthyretin (TTR) amyloidogenesis inhibitors affecting thyroid hormone.<br>References Frederickson, M. et al.: J. Med. Chem., 51, 183 (2008); Johnson, S. et al.: J. Med. Chem., 51, 260 (2008);<br></p>

<p>Applications Cyclopentylacetic acid is a reagent the synthesis of Cyclopentamine (C988355), which is a vasoconstrictor that acts as a releasing agent of the neurotransmitters norepinephrine, epinephrine and dopamine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmidt, J.L. et al.: J. Pharmacol. Exp. Ther., 145, 83 (1964); Iversen, L.L.: J. Pharm. Pharmacol., 16, 435 (1964);<br></p>

<p>Applications 5-Chloropentyl acetate is a Friedel-Crafts haloalkyl ester with antibacterial properties.<br></p>

<p>Applications 2-Aminobenzeneboronic acid pinacol ester is a reagent used to synthesize regiospecific quinolines. It can also be used to synthesize (±)-Epimeloscine and (±)-Meloscine.<br>References Zhang, H., et al.: J. Am. Chem. Soc. 133, 10376 (2011); Horn, J., et al.: Org. Lett 10, 4117 (2008)<br></p>

<p>Applications 3,4-Epoxycyclohexanecarboxylate Methyl Ester is a useful reagent for organic synthesis.<br></p>

<p>Applications 3-Isopropylbenzoic acid<br></p>

<p>Applications Ethyl 4-bromoacetoacetate<br></p>

<p>Applications 2-CYCLOPENTYL-2-PHENYLACETIC ACID (cas# 3900-93-4) is a useful research chemical.<br></p>

<p>Applications tert-Butyl (5-Chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate is used as a reactant in the synthesis of BRAF-kinase inhibitors.<br>References Repik, Alexey E., et al.: PCT Int. Appl., WO 2017146604 A1 20170831 (2017)<br></p>

<p>Applications methyl 2,4-dichlorothiazole-5-carboxylate (cas# 861708-66-9) is a useful research chemical.<br></p>

<p>Applications 5-(Benzyloxy)-2-((benzyloxy)carbonyl)-3-hydroxy-5-oxopentanoic Acid is an intermediate used in the synthesis of 2-[2-[(5-carboxypentyl)amino]-2-oxoethyl]-2-hydroxybutanedioic Acid (C181175), which is derived from Methyl 6-Aminohexanoate Hydrochloride (M287100), which is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.<br>References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)<br></p>

<p>Applications 5-Ethyl-2-fluorophenylboronic acid<br></p>

<p>Applications 2-PHENOXYBENZOIC ACID (cas# 2243-42-7) is a useful research chemical.<br></p>

<p>Applications 4-tert-Butoxyphenylboronic Acid is a compound used in the preparation of nitrophenylphenol via cross-coupling reaction of nitrohalobenzenes with phenylboronic acids and deprotection.<br>References Kumamoto, N., et al.: Preparation of nitrophenylphenol, JP 2001055360 (2001);<br></p>

<p>Applications tert-Butyl ((2S,3R,E)-3-hydroxy-1-((2-oxido-1,3,2-dioxaphospholan-2-yl)oxy)octadec-4-en-2-yl)carbamat is an intermediate for the synthesis of D-erythro-Sphingosylphosphorylcholine (S681700), which is involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction.<br>References Kratzer, B. and Schmidt, R.R.: Liebigs Ann., 955-963 (1995)<br></p>

<p>Applications tert-Butyl Methylcarbamate is an substituent in the synthetic preparation of PF-06463922, a macrocyclic inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1).<br>References Johnson, T. W., et al.: J. Med. Chem., 57, 4720 (2014);<br></p>

<p>Applications 3-(2,3-Dihydroxyphenyl)propionic acid is a degradation product of the aromatic compound Phenylpropionate (PP).<br>References Provencher, S., et al.: Biochemistry, 20, 33 (1981), Ferrandez, A., et al.: J. Bacteriol., 179, 2573 (1997), Torres, B., et al.: J. Biol. Chem., 278, 27575 (2003),<br></p>

<p>Applications 2-(bis(2-(tert-butoxy)-2-oxoethyl)amino)acetic acid (cas# 171557-31-6) is a useful research chemical.<br></p>

<p>Applications 5-Ethyl-6-hydroxyhexanoic Acid is an intermediate in the synthesis of metabolites of Bis(2-ethylhexyl) Phthalate (DEHP) (B433850).<br>References Kaulen, J., et al.: Tetrahedron., 38, 3299 (1982);<br></p>

<p>Applications 3-PHENYLISONICOTINIC ACID (cas# 104096-15-3) is a useful research chemical.<br></p>

<p>Applications Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate, is a building block used in various chemicla synthesis. It can be used for the preparation of six stereoisomers of diaminocyclohexane carboxamide as key intermediates for synthesis of factor Xa inhibitors.<br>References Wang, X. et al.: Tetrahedron, Vol.73, Iss.11, P1381-1388 (2017);<br></p>

<p>Applications 2-(1,3-BENZOTHIAZOL-2-YLTHIO)SUCCINIC ACID (cas# 95154-01-1) is a useful research chemical.<br></p>

<p>Applications 5-[2-(Trifluoromethoxy)phenyl]-2-furancarboxylic Acid is a reactant used in the preparation of (phenyl)-N-[(mercapto)(pyrrolyl)triazolyl]furancarboxamide and (phenoxy)-N-[(mercapto)(pyrrolyl)triazolyl]acetamide derivatives as herbicides.<br>References Xue, S., Lu, C.: Youji Huaxue, 28, 1083 (2008)<br></p>

<p>Applications 2-(5-formylfuran-2-yl)benzoic Acid (cas# 88460-72-4) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxy-3-nitrobenzoic acid<br></p>

<p>Applications Dimethyl-1,3-acetonedicarboxylate is used in the preparation of optically active lycorane. It has also been substituted into bispidone derivatives for their use as ligands in PET imaging.<br>References Yoshizaki, H. et al.: J. Org. Chem., 60, 2016 (1995); Legdali, T. et al.: J. Org. Chem., 77, 11167 (2012);<br></p>

<p>Applications Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br></p>

<p>Applications trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.<br>References Dossetter, A.G., et al.: J. Med. Chem., 55, 6363 (2012); Shao, P.P., et al.: Bioorg. Med. Chem. Lett., 15, 1901 (2005)<br></p>

<p>Applications Benzyl Acetoacetic Amide (cas# 882-36-0) is a compound useful in organic synthesis.<br>References Sakaki, J., et al.: Chem. Pharm. Bull., 37, 2952 (1989),<br></p>

<p>Applications Dimethyl cyclopentane-1,3-dicarboxylate (cas# 2435-36-1) is a useful research chemical.<br></p>

<p>Applications 6-cyano-2-oxaspiro[3.3]heptane-6-carboxylic acid (cas# 1934971-05-7) is a useful research chemical.<br></p>

<p>Applications Used in the preparation of (+)-Lysergic acid and α-Ergocryptine (E597500).<br></p>

<p>Applications 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid is used for preparation of glutamic acid-containing acylating reagents for selective acylation of amino group(s) in peptides or proteins.<br>References Christensen, C., et al.: PCT Int. Appl. (2010), WO 2010084169 A2 20100729.<br></p>

<p>Applications 3,4-Bis(phenylmethoxy)-benzoic Acid is a useful synthetic intermediate. It is an intermediate used to synthesize Jaboticabin (J210370) which is minor bioactive depside potent to treat chronic obstructive pulmonary disease.<br>References Wu, S., et al.: J. Agri. Food Chem., 61, 4035 (2013); Reynertson, K., et al.: J. Nat. Prod., 69, 1228 (2006)<br></p>

<p>Applications Triethyl Orthoacetate is used in the preparation of potent and selective human A3 adenosine receptor antagonists. Also used in the preparation of 1,3,4-oxadiazoles for potential antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Squarcialupi, L. et al.: J. Med. Chem., 56, 2256 (2013); Vodela, S. et al.: Chin. Chem. Lett., 24, 625 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Propylphosphonic Acid, is an alkylphosphonic acid, and a building block used in the synthesis of chemical compounds such as extremely toxic nerve agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deepak P. et al.: J. of Cherom. A. 1141(2), 151-157 (2007);<br></p>

<p>Stability Light Sensitive<br>Applications 3-(3-Hydroxyphenyl)acrylic acid (cas# 588-30-7) is a useful research chemical.<br></p>

<p>Applications 2-Mercapto-succinic acid diethyl ester (cas# 23060-14-2) is a useful research chemical.<br></p>

<p>Applications Diethyl Iminodiacetate<br></p>