Carboxylic Acids

<p>Applications A metabolite of pyrethroid insecticides such as: Deltamethrin, Permethrin, Cypermethrin, Fenvalerate, Decamethrin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Woollen, B., et al.: Xenobiotica, 22, 983 (1992), Saito, K., et al.: Toxicol. Sci., 57, 54 (2000), Fang, H., et al.: Chem. Res. Toxicol., 14, 280 (2001), Andersen, H., et al.: Toxicol. Appl. Pharmacol., 179, 1 (2002),<br></p>

<p>Applications 2-(2-ethoxyethoxy)acetic acid (cas# 7743-94-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethyl Acetate is generally used as a solvent in organic reactions.Environmental contaminants; Food contaminants<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reyes L et al. J Org Chem. 2013 Mar 15;78(6):2327-35.<br></p>

<p>Applications ethyl 2-cyclopropyl-2-hydroxyacetate (cas# 1185387-66-9) is a useful research chemical.<br></p>

<p>Applications Repaglinide intermediate.<br>References Wolfenbuttel, B., et al.: Eur. J. Clin. Pharmacol., 45, 113 (1993), Grell, W., et al.: J. Med. Chem., 41, 5219 (1998), Anon., et al.: Drugs Future, 24, 815 (1999),<br></p>

<p>Applications 3,4,9,10-Perylenetetracarboxylic diimide (cas# 81-33-4) is a useful research chemical.<br></p>

<p>Applications 3,5-DINITRO-4-HYDROXYBENZOIC ACID (cas# 1019-52-9) is a useful research chemical.<br></p>

<p>Applications 2-Ethylhexanoic Acid is used in biological studies as flavor precursor extraction from different grape varieties and its effect on wine aroma during alcohol fermentation<br>References Loscos, N., et al.: J. Agric. Food Chem., 55, 6674 (2007)<br></p>

<p>Applications Phenylglyoxylic Acid (cas# 611-73-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 7-Benzothiazolecarboxylic Acid is an intermediate used in the synthesis of pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1). It is also used to prepare aminofuro-pyridine derivatives as inhibitors of TAK1.<br>References Huynh, T., et al.: Bioorg. Med. Chem. Lett., 19, 2924 (2009); Horneberger, K., et al.: Bioorg. Med. Chem. Lett., 23, 4517 (2013)<br></p>

<p>Applications (±)-Jasmonic Acid can be used as reactant/reagent for synthetic preparation of fluorescent-labeled jasmonate and application to fluorescent imaging in cabbage seedlings.<br>References Liu, S., et al.: Tetrahedron Lett., 53, 4235-4239 (2012)<br></p>

<p>Applications Reagent used in the synthesis of cyhalothric pesticides and fungicides.<br>References Sun, C., et al.: Bioorg. Med. Chem., 14, 8574 (2006),<br></p>

<p>Applications 3-Azidopropionic Acid is a mutagenic substance.<br>References LaVelle, J. M., et al.: Mutat. Res., 177, 27 (1987); Carlsson, L., et al.: J. Chem. Inf. Model., 49, 2551 (2009)<br></p>

<p>Impurity Sulfadimethoxine EP Impurity D/ Mesalazine EP Impurity O<br>Applications Sulfanilic Acid (Sulfadimethoxine EP Impurity D) is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.<br>References Collins, T., et al.: Food Chem. Toxic., 28, 821 (1990), Levine, W., et al.: Drug Metab. Rev., 23, 235 (1991), Sasaki, Y., et al.: Mutat. .Res., 519, 103 (2002),<br></p>

<p>Applications Methyl cyclopropane carboxylate is used as a reagent in the synthesis of N’-thiazole and N-pyrazole based inhibitors of MAP kinase p38α.<br>References Getlik, M. et al.: Eur. J. Med. Chem., 48, 1 (2012);<br></p>

<p>Applications A benzoic acid derivative used in photolysis reactions and biomaterial studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wetzels, G.M. et al.: Biomaterials., 20, 1879 (1999); Mao, C. et al.: Adv. Coll. Int. Sci., 110, 5 (2004);<br></p>

<p>Applications Di-β,β'-Chloroethylphosphoric Acid, is a dialkyl hydrogen phosphates, that can undergo the electrophilic trifluor- omethylation to produce trifluoromethyl phosphates in order to increase the lipophilicity of functional groups.<br>References Santschi, N., et al.: J. Fluorine Chem., 135, 83 (2012);<br></p>

<p>Applications Fumaric Acid is a compound that occurs in many plants. It is essential to vegetable and tissue respiration and also used as an antioxidant. Fumaric Acid is also a metabolite of Dimethyl Fumarate (D464965), a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.<br>References Jelitto, T., et al.: Planta, 188, 238 (1992); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Son, H., et al.: J. Agric. Food Chem., 56, 8007 (2008);<br></p>

<p>Applications 2,3-Dihydroxypropanoic acid(20% in water) (cas# 473-81-4) is a useful research chemical.<br></p>

<p>Applications Phosphoric acid, ammonium salt (1:1) is a useful reagent for organic synthesis.<br></p>

<p>Applications 4-Sulfamoylbenzoic Acid is used as a reagent in the synthesis of carbonic anhydrase inhibitors anticonvulsant agents.<br>References Singh, S. et al.: J. Enz. Inhib. Med. Chem., 31, 417 (2016);<br></p>

<p>Applications (3E,7E)-4,8,12-Trimethyl-3,7,11-tridecatrienoic Acid is a compound involved in a study on ligand-controlled regiodivergent Ni-catalyzed reductive carboxylation of allyl esters with CO2.<br>References Moragas, T., et al.: J. Am. Chem. Soc., 136, 17702-17705 (2014)<br></p>

<p>Applications Magnesium Monoperoxyphthalic Acid Hexahydrate is used as an oxidant in various synthetic reactions. For example: it is a mild and efficient oxidant for the synthesis of selenones which are useful synthetic intermediates in the synthesis of different heterocyclic compounds.<br>References Temperini, A., et al.: Beilstein J. Org. Chem., 10, 1267 (2014); Salvador, J.A.R., et al.: Beilstein J. Org. Chem., 8, 164 (2012); Carvalho, J.F.S., et al.: Tetrahedron, 65, 2773 (2009)<br></p>

<p>Applications Bromochloroacetic acid is a halogenated disinfection byproduct commonly found in drinking water, fruit juice, and cheese. Bromochloroacetic acid has been shown to cause mesothelioma, fibroadenomas, and adenomas in rats<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hang, C., et al.: Sci Total Environ. 543, 425 (2016); Cardador, M. J. and Gallego, M.: Food Chem. 173, 685 (2015); Natl Toxicol Program Tech Rep Ser. 549, 1 (2009)<br></p>

<p>Applications o-Arsanilic Acid is an organoarsenic compound. o-Arsanilic Acid is a highly toxic contaminant and can be found in plants growing in contaminated soil.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmidt, A.-C. et al.: Chemosphere, 73, 1781 (2008);<br></p>

<p>Applications Hexacosanoic acid ((1S,2S,3R)-2,3-dihydroxy-1-hydroxymethyl-heptadecyl)-amide is a ceramide found in the moro blood orange (Citrus sinensis). It is a useful building block used in the preparation of 5-thio-α-GalCers as immunostimulators for IFN-​γ production stimulation in mouse NKT cells.<br>References Bi, J.; et al.: ACS Med. Chem. Lett., 6, 476 (2015); Valsecchi, M.; et al.: J. Agric. Food Chem., 60, 10103 (2012).<br></p>

<p>Applications Morpholin-​4-​yl Acetic Acid was used in preparation of pyrrolidine-fused fullerene multicarboxylates by photoreaction.<br>References Gan, L., et al.: J. Org. Chem., 63, 4240 (1998).<br></p>

<p>Applications An effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells.<br>References Yang, T. et al.: J. Med. Chem., 50, 6458 (2007);<br></p>

<p>Applications A metabolite of aldehydes.<br>References Shiobara, Y., et al.: Xenobiotica, 9, 157 (1979),<br></p>

<p>Applications Boric Acid, Pinacol Ester was a useful reagent in the study of hydrogen peroxide inducible DNA croslsinking agents as anticancer prodrugs.<br>References Kuang, Y., et al.: J. Am. Chem. Soc., 133, 19278 (2011);<br></p>

<p>Applications 2-(4-((1-(Methoxycarbonyl)-2-oxocyclopentyl)methyl)phenyl)propanoic Acid is a reagent used in the preparation of Loxoprofen Sodium<br>References Liu, Q., et al.: Faming Zhuanli Shenqing (2016), CN 105218351 A 20160106<br></p>

<p>Applications Butyl Acetate, can be used as a synthetic fruit flavoring in foods such as candy, ice cream, cheeses, and baked goods.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ullman's encyclopedia of industrial chemistry, 6th Ed., 1, 170 (2003);<br></p>

<p>Applications Z-2-Fluoro-3-(3-pyridyl)acrylic Acid (cas# 359435-42-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope labelled Trifluoroacetic Acid used as a solvent in a variety of organic synthesis and chemical processes. Used in the synthesis of anticancer agents as well as phospholipase D inhibitors.<br> E0<br>References Scott, S. et al.: Nat. Chem. Biol., 5, 108 (2009); Minko, T. et al.: Cancer. Chemother. Pharmacol., 50, 143 (2002);<br></p>

<p>Applications butyl carbamate (cas# 592-35-8) is a useful research chemical.<br></p>

<p>Applications DL-3-Aminoisobutyric acid (cas# 144-90-1) is a useful research chemical.<br></p>

<p>Applications Phthalic Acid Bis(3,7-dimethyloctyl) Ester is a diester derivative of Phthalic Acid (P384480) and can be used as a plasticizer for PVC-type compositions.<br>References Takeuchi, H., et al. Jpn. Kokai Tokkyo Koho. JP 2001002829 A 20010109. Jan 9, 2001<br></p>

<p>Applications Reagent used in the addition of Phenothiazine (P318040).<br>References Zhang, Y., et al.: Bioorg. Med. Chem. Lett., 17, 707 (2007), Bansode, T., et al.: Pharm. Chem. J., 43, 311 (2009), Chelikani, R., et al.: App. Biochem. Biotechnol., 157, 263 (2009),<br></p>

<p>Applications Methyl 2-Cyano-2-oximinoacetate is an intermediate in synthesizing 2-Cyano-2-(methoxyimino)acetic Acid (C989423), which is a cyano-oxime derivative used as a fungicide.<br>References Tellier, F., et al.: Pestic Biochem Physiol., 78, 151-160 (2004)<br></p>

<p>Applications (8Z,11Z,14Z)-8,11,14-Heptadecatrienoic Acid, is a naturally occurring hydroxylated fatty acid that is found in Acinetobacter species. It acts as a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40) and GPR84 receptors in vitro. It also inhibits bovine hepatic ligase (Ki = 4.4 μM) and mouse kidney mitochondrial medium-chain acyl-CoA synthetase by 48% at a concentration of 40 μM.<br>References Moss, C.W., et al.: J. Clin. Microbiol. 26(3), 484-492 (1988).; Kaspersen, M.H., et al.: Med. Chem. Commun. 8(6), 1360-1365 (2017).<br></p>

<p>Stability Hygroscopic<br>Applications Heptafluorobutyric Acid (HFBA) is used in reversed-phase chromatography.<br> E0<br>References Satake, I., et al.: Biopolymers, 15, 2263 (1976), Aso, K., et al.: Biosci. Biotech. Biochem., 56, 755 (1992), Cecchi, T., et al.: J. Chromatogr., 1216, 1789 (2009),<br></p>

<p>Applications 2-Hydroxyphenylacetic Acid (cas# 614-75-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Phenyl N-​(2-​Chloro-​4-​hydroxyphenyl)​carbamate is a reagent used in the prepartion of quinoline-carboxamide compounds including Lenvatinib (L329400), an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.<br>References Wang, N. et al.: Faming Zhuanli Shenqing (2017), CN 106632033 A 20170510.<br></p>

<p>Applications Isobutylsuccinic Acid was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.<br>References Groutas, W., et al.: Bioorg. Med. Chem., 3, 375 (1995);<br></p>

<p>Applications Used for the preparation of bisphosphonic acid derivatives as anti-osteoporosis agents.<br>References Amin, D., et al.: Drug Res., 46, 759 (1996), Martin, M., et al.: J. Med. Chem., 45, 2904 (2002),<br></p>

<p>Applications 1-Cyclohexenylcarboxylic Acid is a reagent used in the synthesis and optimization of small-molecule HIV-1 entry inhibitors. Also used in the stereoselective synthesis of diazabicyclic β-lactams for antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tuyishime, M. et al.: Bioorg. Med. Chem. Lett., 24, 5439 (2014); Zhang, S. et al.: J. Org. Chem., 81, 956 (2016);<br></p>

<p>Applications Urocanic acid (cas# 104-98-3) is a useful research chemical.<br></p>