Naphthalenes

1,2-Naphthoquinone is a reactive chemical that binds to DNA. It has been shown to inhibit the growth of cultured tumor cells in a genotoxic and cytotoxic manner. 1,2-Naphthoquinone inhibits the activity of many enzymes and has been used in pharmacological experiments on animal models. It is also used as a reagent for organic synthesis and as an intermediate for the production of other chemicals. The redox potential of 1,2-naphthoquinone can be determined by titration calorimetry.

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2-(Bromomethyl)naphthalene is a chemical that has been studied extensively for its ability to inhibit the growth of cancer cells. It binds with high affinity to the mitochondrial membrane potential and inhibits the production of ATP, leading to cell death. 2-(Bromomethyl)naphthalene has also been shown to produce reactive oxygen species (ROS), which can also induce tumor cell death. This compound has been used in a variety of biological samples, including urine samples, which have shown promising results. A potential target for this drug is an enzyme called hydrolysis, which may be found at higher concentrations in tumor cells. The proposed reaction mechanism is shown below: 2- (bromomethyl) naphthalene + H 2 O → bromide ion + 2- (hydroxymethyl) naphthalene The kinetic data and diphenyl sulfoxide are unknown at this time.

4-Amino-5-hydroxy-2,7-naphthalenedisulfonic acid (4-AHNDS) is a hydroxyl group and nitrogen containing molecule. It is a reactive compound that can be used to extract anions from water. 4-AHNDS has been shown to react with sodium ions in the presence of water, forming a salt that is soluble in water. This chemical also reacts with organic molecules and forms stable complexes. The reaction mechanism of 4-AHNDS has been studied by kinetic analysis and surface methodology measurements.

2-Naphthol-6,8-disulfonic acid is a synthetic organic compound that was identified as an impurity in the glyphosate formulation, Roundup. 2-Naphthol-6,8-disulfonic acid has been shown to have good analytical properties and can be used for the analysis of glyphosate in wastewater samples. It is thermally stable with a melting point of about 220°C. The UV detection wavelength ranges from 220nm to 240nm and the chloride ion is detectable at concentrations greater than 0.1 ppm. 2-Naphthol-6,8-disulfonic acid can also be used for the analysis of fatty acids in plants and animals.

6-Hydroxy-1-naphthoic acid is a synthetic carboxylate compound with an analog structure that has been shown to be cytotoxic to cancer cells. It inhibits the activity of protein kinases by binding to ATP, which blocks the phosphorylation of tyrosine residues on proteins. 6-Hydroxy-1-naphthoic acid has been shown to inhibit growth factor receptors and induce apoptosis in tumor cells. The mechanism of action for this drug is believed to be through ring opening and hydrolysis of the naphthalene ring, followed by reaction with p-hydroxybenzoic acid. This results in inhibition of histone deacetylase activity, leading to decreased expression of genes involved in cell proliferation.

Disodium 8-amino-1,3,6-naphthalenetrisulfonate is a fluorescent sensor that can detect albumin in human serum. Disodium 8-amino-1,3,6-naphthalenetrisulfonate selectively detects the molecule albumin in blood with a sensitivity of approximately 1.5 nmol/L and a selectivity of nearly 100%. The fluorescent sensor consists of an immobilized nanometer sized molecule of 8-aminonaphthalene trisulfonic acid on hydrotalcite. The sensor has been shown to be selective for albumin and does not react with other serum proteins such as immunoglobulins or fibrinogen.