Pharmaceutical Standards

Applications N-Nitro-S-methylisothiourea is used as a reactant in the preparation of 1,5-substituted-1,3,5-hexahydrotriazine-2-N-nitroimines with insecticidal activity.
References Xue, S., et. al.: J Heterocyciic Chem., 50, 1067 (2013)

Applications (4S-cis)-4-(1-Hydroxy-1-methylethyl)-2,2,5-trimethyl-1,3-dioxolane-4-carboxylic Acid is an intermediate in the synthesis of (+)-Echimidine N-Oxide, which is a hepatotoxic pyrrolizidine alkaloid. Different extracts and echimidine-N-oxide from Symphytum sylvaticum Boiss. Subsp. sepulcrale, has been shown to have Antifungal activity.
References Kartal, M., et al.: Turkish, J. Med. Sci., 31, 487 (2001); Cao, Y., J. Food Comp. Anal., 29, 106 (2013);

Applications 7-​[[4-​[Bis(3-​amino-​3-​oxopropyl)​amino]​-​6-​chloro-​1,​3,​5-​triazin-​2-​yl]​amino]​-​4-​hydroxy-​3-​[2-​(4-​methoxyphenyl)​diazenyl]​-2-​naphthalenesulfonic Acid 1-​Methylethyl Ester is an intermediate in synthesizing 7-[[4-[Bis(3-Amino-3-oxopropyl)amino]-6-chloro-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(4-methoxyphenyl)azo]-2-naphthalenesulfonic Acid (B426265), which acts as a non-peptide hormone receptor antagonist affecting physiological homeostasis and reproduction. Hormone antagonist.
References Arey, B. et al.: Endocrinol., 143, 3822 (2002); Wrobel, J. et al.: Synth. Comm., 32, 2695 (2002)

Applications 5-Acetamidonaphthalene-1-sulfonamide (cas# 32327-48-3) is a compound useful in organic synthesis.

Applications (+)-2-Hydroxypinocamphone is an essential oil of inflorescence and leaf of various species of Thymus L. These essential oils were shown to be useful for medical, flavoring and food preservation purposes.
References Hoeferi, M., et al.: Ernahrung., 37, 197 (2013);

Applications N,N'-Dimethylurea

Applications Intermediate used in the addition of protected Glucopyranuronic Acid.

Applications tert-Butyldimethylsilyloxy-5-aza-2'-deoxycytidine is an intermediate in the synthesis of metabolites of Azadeoxycytidine (A796950), as neoplasm inhibitor.
References Cihak, A., et al.: Eur. J. Cancer, 14, 117 (1978),

Applications DL-10-Camphorsulfonyl Chloride is used as a the starting material in the synthesis of 10-Camphorsulfonic Acid Ethyl Ester (C175040). It is also used as a reagent in the synthesis of 1-benzhydrylpiperazine derivatives which can exhibit antiproliferative activity in vitro against human cancer cell lines.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ananda Kumar, C.S., et al.: Eur. J. Med. Chem., 44, 1223 (2009)

Applications 5’-Deoxy-2’,3’-O-isopropylidene-5-fluorouridine-13C,15N2 is a compound useful in organic synthesis.

Applications Oxidizing reagent.

Applications Intermediate for the synthesis of glucuronide conjugates of trans-Resveratrol
References Learmonth, D.A., et al.: Bioconjug. Chem., 14, 262 (2003),

Applications p-Chloroacetophenone is a chemical reagent used in the synthesis of various pharmaceutically and biologically active compounds such as COX-2 inhibitors.
References Penning, T. et al.: J. Med. CHem., 40, 1347 (1997); Wolfe, J. et al.: Angew. Chem. Int. Ed., 38, 2413 (1999);

Applications Can be used in the preparation of CCR5 antagonists, for treatment of HIV-1.
References Tallant, M. et al., Bioorg. Med. Chem. 21, 1394 (2011)

Applications 2,3-Dichlorobenzoic Acid-13C,d3 is an intermediate in synthesizing Lamotrigine-13C3,d3 (L173253), an isotopically labelled Lamotrigine (L173250), an anticonvulsant. Inhibits glutamate release, possible through inhibition of Sodium, Potassium and Calcium currents. Used in treatment of bipolar depression.
References Miller, A.A., et al.: Epilepsia, 27, 483 (1986); Grunze, et al.: Neuropsychobiology, 38, 131 (1998); Calabrese, J.R., et al.: J. Clin. Psychiatry, 60, 79 (1999)

Applications Intermediate in the synthesis of polycyclic aromatic systems.

Applications N-​(Methoxycarbonyl)​-L-​glutamic Acid 5-​Ethyl Ester is an intermediate in synthesizing (S)-Vigabatrin (V253000), a novel anti-epileptic drug. Antidepressant; antipsychotic; anxiolytic.
References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000); Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004); Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006);

Applications Intermediate in the preparation of olefins, butenolides and nitro butyrolactones.
References Beugelmans, R. et al.; B. Soc. Chim. Fr. 131, 1019 (1994)

Applications N'-[(2-Chloro-5-thiazolyl)methyl]-N-nitro-carbamimidothioic Acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1(C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.
References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications 1,2-Dimethylisothiourea-HI (cas# 41306-45-0) is a useful research chemical.