Pharmaceutical Standards

Applications Ethyl Cyano(2-nitrophenyl)acetate (cas# 65548-02-9) is a compound useful in organic synthesis.

Applications Used in the synthesis of phenacetin metabolites.
References Focella, A. et al.: Can. J. Chem. 50, 2025 (1972)

Applications 2’,3’,5’-Tri-O-acetyladenosine (cas# 7387-57-7) is a compound useful in organic synthesis.

Applications 2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione (cas# 31267-07-9) is a useful research chemical.

Applications Cyclobutanecarboxylic Acid, can be used as an organic building block in the chemical synthesis. It is also an Antiinflammatory agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Grassy, G. et al.: Euro. J. Med. Chem., 14, 493, (1979);

Applications 2-Amino-4-chloro-3-nitropyridine (cas# 6980-08-1) is a compound useful in organic synthesis.
References Bavetsias, V., et al.: Bioorg. Med. Chem. Lett., 17, 6567 (2007), Niculescu-Duvaz, D., et al.: J. Med. Chem., 52, 2255 (2009),

Applications The sex pheromone of the currant shoot borer Lampronia capitella.
References Ochiai, M., et al.: Chem. Pharm. Bull., 31, 1641 (1983), Ando, T., et al.: Agric. Biol. Chem., 52, 1415 (1988), Kozlov, M., et al.: J. Chem. Ecol., 22, 431 (1996),

Applications Uridine 5’-Diphospho-N-Acetylquinovosamine is an analogue of FlaA1, a bifunctional UDP-​GlcNAc C6 dehydratase​/C4 reductase from Helicobacter pylori.
References Creuzenet, C., et al.: J. Biol. Chem., 275, 34873 (2000)

Applications 2-Chloro-5-nitropyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).
References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)

Impurity Fulvestrant Impurity E;
Applications Fulvestrant (F862500) impurity E.

Impurity Atorvastatin 2-Hydroxy Lactone
Stability Hygroscopic
Applications A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Applications 2-Methyl-6-vinyl-pyrazine can be found in the aroma of beef muscle, popcorn, coffee, and malted barley. It can also be utilized to analyze the thermal behaviour of pyridine esters.
References Beal, A. D. and Mottram, D. S. J. Agric. Food Chem. 42, 2880 (1994); Lai, M., et al.: J. Therm. Anal. Calorim. 123, 479 (2016)

Applications 4-Bromo-1,8-naphthalic Anhydride is used as a starting material in the synthesis of a fluorescent probe for the detection of copper ions in living human LO-2 cell lines.
References He, Guangjie, et al.: PLoS One, 12(10), e0186994/1-e0186994/11 (2017)

Impurity Everolimus Impurity
Stability Light and temperature Sensitive
Applications Everolimus Retroaldol Degradation Product is an impurity of Everolimus (E945400). Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. Everolimus Impurity D
References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),

Stability Acid Sensitive
Applications 17β-(Trimethylsiloxy)testosterone is an anabolic steriod, and a derivative compound of Testosterone (T155000), Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol.Testerone is a controlled substance (anabolic steroid). Androgen.
References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001),

Impurity Valproic Acid USP Related Compound A
Applications Diallylacetic Acid (Valproic Acid USP Related Compound A), is a metabolite of Valproic Acid (V094750) as anticonvulsant agents. It can also be used for the synthesis of Velbanamine.
References Liu, H., et al.: Beilstein J. Org. Chem., 9, 983 (2013); Loscher, W., Prog. Neurobiol., 58, 31 (1999); Netzeva, T., et al.: Pharmac. Res., 17, 727 (2000);

Applications A short-chain haloalkene isotope.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Benzyl N-(4-nitrophenyl)carbamate

Applications 17β-neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. It can also work as an inhibitor of hERG channel trafficking.
References Zhao, Q., et al.:Fitoterapia, 82, 735 (2011); Wang, L., et al.: J. Pharmacol. Exper. Ther., 320, 525 (2007)

Impurity Beclomethasone Dipropionate EP Impurity I
Applications (16β)-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4,9(11)-triene-3,20-dione (Beclomethasone Dipropionate EP Impurity I) is an impurity of Beclomethasone (B131000), a glucocorticoid. Used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant). Anti-inflammatory (topical).
References Malfitan, V.A., et al.: Clin. Ther., 4, 472 (1982), Rao, M., et al.: J. Asthma, 19, 21 (1982), Small, P., et al.: Ann. Allergy, 49, 127 (1982), Brogden, R.N., et al.: Drugs, 28, 99 (1984),

Applications Labelled 3-(3,4-Dimethoxyphenyl)propanoic Acid (D460730), one of the novel circulating coffee metabolites in human plasma.
References Clifford, M., et al.: J. Sci. Food Agric., 80, 1033 (2000), Mateos, R., et al.: J. Agric. Food Chem., 54, 8724 (2006), Wong, C., et al.: J. Nutr. Biochem., 21, 1060 (2010),

Applications cis-7,10,13,16-Docosatetraenoic Acid Methyl Ester-d3 is a labelled analog of cis-7,10,13,16-Docosatetraenoic Acid Methyl Ester. cis-7,10,13,16-Docosatetraenoic Acid Methyl Ester is used in oregano essential oil as an inhibitor of higher fatty acid oxidation.
References Terenina, M.B., et al.: Appl. Biochem. Microbiol., 47, 445 (2011)

Applications 6-Bromo-3-fluoro-2-nitrophenol is an intermediate to prepare modulators of metabotropic glutamate receptors.
References Bessis, A., et al.: PCT Int. Appl., WO 2005123703 A2 20051229 (2005)

Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid is an impurity of Rabeprazole. It is also a degradation product formed in stressed tablets of Rabeprazole sodium.
References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999); Carswel, C., et al.: Drugs, 61, 2327 (2001); Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008)

Applications 1-Formylcyclohexanecarboxylic Acid Methyl Ester (cas# 84393-05-5) is a useful research chemical.

Applications Cyclo (-RGDfK) Trifluoroacetic Acid Salt is a potent inhibitor of αvβ3 integrin. Used in tumor therapy due to the targeting of the VEGFR2 gene by sRNA.
References Liu, L. et al.: Int. J. Nanomed., 9, 3509 (2014);

Applications Methyl 3'-Amino-1,1'-biphenyl-3-carboxylate is a useful reagent for organic synthesis and other chemical processes.
References Uehling, D. E., et al.: J. Med. Chem., 49, 2758 (2006); Kuppusamy, R., et al.: Eur. J. Med. Chem., 143, 1702 (2018)

Applications Dibutyl Carbonate-d18 is the deuterated form of Dibutyl Carbonate (D427995), which is a potential fuel substitute due to the observed decrease in CO2 emissions. Also used in CO2 catalytic activation.
References Hellier, P. et al.: Energy Fuel, 27, 5222 (2013); Shang, J. et al.: Green Che,., 14, 2899 (2012);

Applications Methyl 3,4,5-trimethoxycinnamate (cas# 7560-49-8) is a useful research chemical.

Stability Hygroscopic
Applications Halogenated nucleoside.
References Sodum, R., et al.: Chem. Res. Toxicol., 11, 1453 (1998),

Applications 4-Nitrophenyl 1H-Indole-3-acetic Acid Ester is an intermediate used in the synthesis of Indole-3-acetyl-L-aspartic Acid (I577370), which is an indole-3-acetyl-amino acid conjugate involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses.
References Ostrowski, M., et al.: J Plant Physiol, 191, 63-72 (2016)

Applications 4-Chlorobiphenyl-2',3',4',5',6'-d5 (CAS# 51624-37-4) is a useful isotopically labeled research compound.

Applications 6-Methyl-2,3'-bipyridine (cas# 78210-78-3) is a useful research chemical.

Applications 2’,3’,5’-Tri-O-benzoyl Xanthine-13C5 is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.
References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);

Applications 2,6-Dimethylnaphthalene-d12 (CAS# 350820-12-1) is a useful isotopically labeled research compound.