Pharmaceutical Standards

<p>Applications Labelled Vanillin. Occurs naturally in a wide variety of foods and plants such as orchids; major commercial source of natural vanillin is from vanilla bean extract. Synthetically produced in-bulk from lignin-based byproduct of paper processes or from guaicol.<br>References Jenner, P.M., et al.: Food Cosmet. Toxicol., 2, 327 (1964), Clark, G.S., et al.: Perfum. Flavor., 15, 45 (1990),<br></p>

<p>Applications Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.<br>References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),<br></p>

<p>Simvastatin is a hydrated, acylated statin that is used as a lipid-lowering drug. It inhibits HMG-CoA reductase, an enzyme that plays a central role in cholesterol biosynthesis. The reaction solution can be activated by mixing with an acyltransferase and the desired acyl group. Simvastatin has a toxicity profile that includes myopathy, rhabdomyolysis, and liver failure. Simvastatin also inhibits lipoprotein lipase and prevents the hydrolysis of triglycerides to fatty acids and glycerol. This leads to reduced levels of low-density lipoproteins (LDLs) and increased levels of high-density lipoproteins (HDLs). Simvastatin is converted into an amide form by enzymatic cleavage, which may lead to metabolic inhibition.</p>

<p>1-(3,4-Methylenedioxyphenyl) 2-nitropropene (1-MPNP) is a phosphatase inhibitor that is active against gram-negative bacteria by inhibiting enterotoxins and chlamydia. 1-MPNP inhibits the activity of tyrosine phosphatases, which are enzymes that play a major role in bacterial virulence. 1-MPNP competitively inhibits the activity of tyrosine phosphatases and prevents them from catalyzing the hydrolysis of polyphosphate substrates. This inhibition leads to an accumulation of polyphosphates in the bacterial cell membrane, which disrupts its permeability and leads to cell death.</p>

<p>4-N-Butoxycinnamic acid is a chemical compound with the molecular formula CH3(CH2)7COCH=CH(COOH). It belongs to the group of cinnamic acid derivatives, which are organic compounds that may be synthesized by condensation of malonic acid and benzene. 4-N-Butoxycinnamic acid has been shown to have anti-inflammatory properties in animal models. This compound inhibits inflammatory cytokines and their signaling pathways, thereby preventing the translocation of neutrophils into inflamed tissues.</p>

<p>3,3',4',5,5',8-Hexahydroxyflavone is a naturally occurring flavonoid, which is a type of polyphenolic compound. It is derived from various plant sources, including fruits, vegetables, and certain medicinal herbs. The compound is characterized by its chemical structure, which includes multiple hydroxyl groups, contributing to its biological activity.<br><br>The mode of action of 3,3',4',5,5',8-Hexahydroxyflavone involves its interaction with various cellular pathways and enzymes. Primarily, it is known for its antioxidant properties, where it scavenges free radicals and reactive oxygen species, thereby reducing oxidative stress. Additionally, it may exhibit anti-inflammatory effects by modulating signaling pathways involved in inflammation.<br><br>In terms of uses and applications, 3,3',4',5,5',8-Hexahydroxyflavone is primarily explored in scientific research focusing on its potential health benefits. Studies investigate its role in disease prevention, particularly conditions associated with oxidative stress and inflammation, such as cardiovascular diseases and neurodegenerative disorders. While it holds promise in these areas, further research is necessary to fully understand its mechanisms and therapeutic potential.</p>

<p>Fluorescent probe for AMC-based labelling of oligosaccharides or peptides</p>

<p>Applications N-Acetylethylene Urea-d4 (cas# 1189701-94-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Guanosine-5'-triphosphate disodium salt (CAS# 56001-37-7) is a nucleotide used in the preparation of photoreactive GTP affinity probes, and in inhibitors of eukaryotic initiation factor eIF-4E.<br>References George Cisar, E. A.; J. Am. Chem. Soc., 135, 4676 (2013); Ghosh, P.; et al.: Bioorg. Med. Chem. Lett., 16, 750 (2006).<br></p>

<p>Applications Triethylborane reacted with 8-hydroxyquinoline to synthesize three 8--​hydroxyquinolato (q) boron compounds B(C2H5)​2q (1)​, BPh2q (2)​, and B(2-​naph)​2q (3).<br>References Wu, Q., et al.: Chem. Mater., 12, 79 (2000).<br></p>

<p>Rengasin-3'-O-glucoside is a fine chemical, useful building block, and research chemical. It is a versatile building block that can be used in the synthesis of complex compounds. Rengasin-3'-O-glucoside is also a useful intermediate or scaffold for reactions. This compound has been shown to react with 1,2-ethanediol and form an ester, which can be hydrolyzed to release glycerol and the original rengasin-3'-O-glucoside.</p>

<p>Please enquire for more information about (4-nitrophenyl)-N-(3-(trifluoromethyl)phenyl)formamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Applications The formation of p-Cresol-(methyl-13C) via phenol methylation at higher temperature from the deactivation of basic catalyst.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Borodina, I. B., et al.: Russ. J. Phys. Chem., 80, 892-898 (2006)<br></p>