Glycoscience

<p>Donor for Koenigs-Knorr type galactosylation and other anomeric substitutions</p>

<p>1,2-O-Isopropylidene-a-D-glucofuranose (IPDF) is a natural compound that has been isolated from the leaves of the plant Cinnamomum camphora. IPDF has been shown to have biological properties such as inhibiting hl-60 cells and inducing apoptosis in leukemia cells. The metabolic rate of IPDF was studied in isolated hearts and it was found that the compound slows fatty acid oxidation. The enzyme substrate specificity of IPDF was also tested by adding trifluoroacetic acid, which yielded no reaction.</p>

<p>5-O-tert-Butyldiphenylsilyl-2,3-O-isopropylidene-D-ribofuranose is a synthetic compound that is an inhibitor of adenosine deaminase. This drug has been shown to inhibit the synthesis of nucleic acids and other biological molecules such as amino acids and proteins. 5-O-tert-Butyldiphenylsilyl-2,3-O-isopropylidene ribofuranose is used in organic chemistry as a chiral analog for naturally occurring compounds such as adenosine. 5BPSSIROdR inhibits the enzyme adenosine deaminase by binding to its active site and preventing it from converting adenosine into inosine.</p>

<p>1,2:3,4-Di-O-isopropylidene-a-D-galactopyranose, also known as diacetone-D-galactose and galactose diacetonide, is a partially protected monosaccharide building block with isopropylidene groups on the 1,2 and 3,4 hydroxyls. The 6-hydroxyl is unprotected and able to undergo a variety of chemical transformations, such as glycosylation acting as a glycosyl acceptor to form 1,6-linked disaccharides.</p>

<p>Tri-b-GalNAc-amine formate salt is an ASGPR-targeted ligand for therapeutics and diagnostics. With three terminal beta-GalNAc (N-acetylgalactosamine) sugars in a trivalent configuration, its high-affinity permits binding to the asialoglycoprotein receptor (ASGPR) on hepatocytes. Notably, the presence of a protonated primary amine group allows for chemoselective bioconjugation with various functional moieties via established amide bond formation techniques. Its salt form (TFA salt) enhances the water solubility of the molecule, facilitating its use in aqueous reaction buffers commonly employed in bioconjugation protocols. This combination of specific ASGPR targeting and a readily available conjugation site makes tri-b-GalNAc-amine TFA a valuable tool for developing customized and targeted drug-GalNAc conjugates, siRNA delivery vehicles, or ASGPR-specific probes. The use of TFA as a counterion ensures efficient deprotonation of the amine during conjugation, potentially improving reaction efficiency.</p>

<p>This peracetylated tri-b-GalNAcAc3-NHCbz, a triantennary N-acetylgalactosamine (GalNAc) ligand with protected functionalities, serves as a valuable building block for ASGPR-targeted therapies. Its three branches or arms, each ending in a GalNAc sugar, ensure strong binding to hepatocyte ASGPR. However, the key feature lies in its protective groups: acetylated sugars allow for controlled removal to expose reactive sites for conjugation, while the Cbz-protected amine provides stability and can be selectively cleaved to introduce a reactive amine group for further biomolecule attachment, ultimately enabling researchers to tailor Tri-b-GalNAcAc3-NHCbz into customized conjugates for specific therapeutic applications.</p>

<p>Nonyl b-D-thiomaltopyranoside is a custom synthesis of an oligosaccharide and polysaccharide. It is prepared by the modification of saccharides with methylation, glycosylation and carbamylation. The compound has CAS No. 148565-55-3 and can be used as a fluorescent probe for carbohydrate binding proteins. Nonyl b-D-thiomaltopyranoside is a high purity synthetic sugar that has been fluorinated. Click modification has been performed on this sugar to create a fluorescent probe for carbohydrate binding proteins. This sugar has also been synthesized using the technique of glycosylation, which involves the addition of monosaccharides to form disaccharides or polysaccharides.</p>

<p>Cyanidin-3-O-lathyroside chloride is a synthetic compound with antioxidant and anti-inflammatory effects. It is activated by the chloride ion, leading to increased bioavailability of the molecule. Cyanidin-3-O-lathyroside chloride has been shown to have anticancer properties, as well as an ability to activate calcium metabolism in cells. This compound also has a low bioavailability, which may be due to its hydrophobic nature and the fact that it is not orally active. This compound has been shown to be beneficial for cancer therapy because of its ability to inhibit cancer growth, induce apoptosis in cancer cells, and reduce tumor size. Cyanidin-3-O-lathyroside chloride has also been shown to have positive effects on fertility when taken at high doses orally.</p>

<p>Dodecyl maltoside (DDM) is a non-ionic detergent that consists of a hydrophilic maltose head and a hydrophobic long chain alkyl tail. It has a relatively low critical micelle concentration of 0.17 mM and is considered a gentle but powerful detergent. DDM is often the best tool for solubilising/crystallising membrane proteins. Membrane proteins usually have α-helical structures that are easily destroyed when the protein is released from its membrane environment. DDM can often preserve these structures during the solubilisation. In addition, membrane proteins can often be renatured when isolated with DDM.</p>

<p>Esculin is a natural product obtained from the plant Aesculus hippocastanum. Esculin has been shown to have anti-inflammatory properties in experimental models. It also has been shown to inhibit the activity of both human and animal renin, suppressing kidney fibrosis. Esculin was found to be more effective than indomethacin in preventing the progression of renal disease induced by the model system of chronic kidney disease. Esculin also has antioxidant properties and can reduce oxidative stress caused by free radicals, which may contribute to its anti-inflammatory effects. Esculin is a coumarin derivative that can be used as a chromatographic stationary phase for separation and identification of various chemical compounds.</p>

<p>Amphiphilic detergent</p>

<p>N-Decanoyl-N-methylglucamine is a fatty acid that is used as a cationic surfactant in detergents and cleaning products. It has been shown to have conformational properties that can be influenced by the acyl chain length. N-Decanoyl-N-methylglucamine has also been shown to bind to antibodies and other proteins, which may lead to antibody response or changes in their conformation. N-Decanoyl-N-methylglucamine binds to receptors on cells, triggering cell lysis and monoclonal antibody production. The optimum pH for this chemical is between 5 and 6, and it has been shown to undergo titration calorimetry at temperatures greater than 100°C.</p>

<p>2-((4,4,5,5,5-Pentafluoropentyl)oxy)octyl ?-D-maltopyranoside is a fluorinated surfactant that can be used as a substitute for traditional detergents in holding membranes proteins in the soluble fraction and improve their stability.</p>

<p>Custom synthesis, Modification, Fluorination, Methylation, Monosaccharide, CAS No. 160168-40-1, Click modification, Oligosaccharide, Synthetic, saccharide, Polysaccharide, Glycosylation, sugar</p>

<p>Octanoyl D-glucopyranoside is a potent inhibitor of histidine-mediated endocytosis and the activation of NF-κB signaling in human osteoarthritic chondrocytes. It has also been shown to inhibit viral replication by adenovirus. Octanoyl D-glucopyranoside inhibits the activity of several enzymes, including protein kinase C (PKC), nf-kappa B (NF-κB), and photolyase, which are all involved in inflammation. This compound also inhibits transcription, polymerization, and genotype expression. Octanoyl D-glucopyranoside has been shown to be effective against necrosis factor alpha (TNFα) and interleukin 1 beta (IL1β).</p>

<p>Myo-inositol 1,3,4,5,6-pentakisphosphate decasodium salt is a complex carbohydrate that has been modified with fluorine. This modification has been shown to increase the solubility of myo-inositol 1,3,4,5,6-pentakisphosphate decasodium salt in organic solvents. Myo-inositol 1,3,4,5,6-pentakisphosphate decasodium salt is used in the synthesis of oligosaccharides and polysaccharides. It also serves as a substrate for methylation and glycosylation reactions. The synthesis of this compound can be achieved by a Click reaction.</p>

<p>Please enquire for more information about 6-O-Desmethyl donepezil glucuronide sodium (Mixture of Diastereomers) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-O-Benzyl-2-deoxy-1,6-di-O-methoxyphenyl-2-phthalimido-b-D-glucopyranoside is a synthetic glycosylation agent. It is a sugar with an Oligosaccharide structure. 3-O-Benzyl--2'-deoxy--1,6'-di--O--methoxyphenyl--2'-phthalimido--b--D--glucopyranoside has been synthesized by fluorination of the sugar and methylation of the benzyl group. Click modification can be used to modify the carbohydrate to create complex carbohydrates. This compound is made from natural ingredients and has a high purity level.<br>Molecular weight: 592.24 g/mol<br>CAS Number: 251300<br>EINECS Number: 208–831–3<br>Melting Point: 130°C (dec</p>

<p>Octyl 2,3,4,6-tetra-O-acetyl-b-D-glucopyranoside is an analog of 6-(trifluoromethyl)indoxyl beta-D-galactopyranoside. It is a potent antituberculosis agent that inhibits the growth of Mycobacterium tuberculosis and has been shown to be active against other bacteria in vitro. Octyl 2,3,4,6-tetra-O-acetyl-b-D-glucopyranoside inhibits bacterial growth by binding to DNA dependent RNA polymerase and prevents transcription and replication. This compound has been tested for its ability to inhibit neoplastic cell proliferation in humans.</p>

<p>Decyl maltose neopentyl glycol is a model system for studying the interaction of light with carotenoids. The decyl maltose neopentyl glycol molecule has been shown to react with light to produce reactive molecules, such as singlet oxygen and superoxide, which are responsible for tissue damage caused by exposure to sunlight. Decyl maltose neopentyl glycol is also a non-heme iron compound that can be used in x-ray crystal structures to study protein-ligase interactions. Decyl maltose neopentyl glycol is synthesized from fatty acids, which are present in the membrane of cells and play an important role in their interactions with proteins. Decyl maltose neopentyl glycol is used as a model system for plant physiology and sample preparation and has been shown to inhibit protein synthesis in vitro.</p>