Glycoscience

<p>Ulvans are structural polysaccharides present in the cell walls of green algae such as Ulva armoricana, Ulva rotondata, Ulva rigida, Ulva lacterca and Ulva pertusa. They are highly sulphated and contain rhamnose 3-sulphate, xylose, xylose 2-sulphate, glucuronic acid and iduronic acid residues.  Ulvan has several potentially valuable functionalities such as gel formation for agricultural and food applications. It has also an anticoagulant, antioxidant, antihyperlipidemic and antitumor activities that are attractive for pharmaceutical applications.<br>The image was kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.</p>

<p>2N-Fmoc-4N-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-L-aparagine is a modified carbohydrate that is used as a starting material for the synthesis of oligosaccharides and polysaccharides. It is synthesized by reacting 2N-Fmoc-L-serine with 4N-(2,3,4,6-tetraO-(acetyl)-bDglucopyranosyl)-Laparagine. The OAc group provides protection for the amino functions and can be removed in the presence of acid to yield an unprotected L(+)-serine. This product has high purity and can be purchased in various custom synthesis quantities.</p>

<p>4-O-Acetyl-3,6-di-O-triisopropylsilyl-D-galactal is a modified sugar that can be used as a chiral building block in the synthesis of complex carbohydrates. This product is available for custom synthesis.</p>

<p>Mannitol is a sugar alcohol occurring widely in plants and they are exudates, for example, in olive and plane trees (Collins, 2006). It is produced commercially by the catalytic hydrogenation of fructose (Zelin, 2019). Mannitol is used extensively in food and pharmaceutical industries because of its unique functional properties. It is about 50% as sweet as sucrose and has a desirable cooling effect often used to mask bitter tastes. Mannitol is non-cariogenic and has a low caloric content. Mannitol is an osmotic diuretic that is metabolically inert in humans and is used for: the promotion of diuresis before irreversible renal failure becomes established, the promotion of urinary excretion of toxic substances, as an Antiglaucoma agent, and as a renal function diagnostic aid (O’Neil, 2013). Additonally, in 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients (McKenna, 2020).</p>

<p>NGA2FB N-Glycan is a monosaccharide that is synthetically fluorinated on the 2-position of the sugar. It is an oligosaccharide that contains a complex carbohydrate, which is a glycosylation of a polysaccharide with a click modification at the methyl group on the sugar. This product can be custom synthesized to order and offers high purity.</p>

<p>3-[(2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl)thio]-propanoic acid is a modification of an oligosaccharide. It is a complex carbohydrate that has been modified with methylation and glycosylation. This product is synthesized from the raw material, which is a high purity monosaccharide or polysaccharide. 3-[(2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl)thio]-propanoic acid has CAS No. 325410 2 and Mw of 835.5 g/mol. The molecular weight and purity are determined by high performance liquid chromatography (HPLC). The product is soluble in water and ethanol.</p>

<p>Ethyl 2,4,6-tri-O-benzoyl-a-D-thiomannopyranoside is a modification of the oligosaccharide mannan. It is an important component of glycoproteins and glycolipids found in plants, fungi, and bacteria. In plants, this modification plays a role in seed dormancy and germination. In fungi, it is involved in the synthesis of cell walls. In bacteria, it has been shown to be involved in the synthesis of peptidoglycan cell walls. Ethyl 2,4,6-tri-O-benzoyl-a-D-thiomannopyranoside is also used as a reagent for the methylation of carbohydrates and to introduce fluorine atoms into saccharides.<br>Methylation: The introduction of a methyl group into a molecule by the addition of S-adenosyl methionine (SAM) to form S-(</p>

<p>4-O-(b-D-Galactopyranosyl)-D-glucosamine HCl is a synthetic, water soluble, non-digestible oligosaccharide. It has regulatory effects on the utilisation of glucose and lacto-n-neotetraose by various cells in vitro. This compound also inhibits the development of intestinal pathogens in humans and elucidates their sequence specificity. 4-O-(b-D-Galactopyranosyl)-D-glucosamine HCl is used to study the role of this molecule in infant nutrition.</p>

<p>Allyl 4,6-O-benzylidene-b-L-glucopyranoside is a carbohydrate that is synthesized from allyl alcohol and glucose. It is a complex carbohydrate made up of two different saccharides. This product can be custom synthesized to meet your needs. Allyl 4,6-O-benzylidene-b-L-glucopyranoside has been modified by fluorination, methylation and glycosylation. It has the CAS number 133394-02-0 and can be synthesized at high purity levels.</p>

<p>1,2:5,6-Di-O-isopropylidene-3-O-tosyl-a-D-gulofuranose is an oligosaccharide modification. The compound is a complex carbohydrate that can be synthesized with high purity and monosaccharide methylation. It can be used as a glycosylation or saccharide fluorination agent for the synthesis of polysaccharides. 1,2:5,6-Di-O-isopropylidene-3-O-tosyl-a-D-gulofuranose is also known by its CAS number 19131–06–7.</p>

<p>Nonyl b-D-thioglucopyranoside is a methylating agent that can be used in the synthesis of oligosaccharides and polysaccharides. This compound is a fluorinated sugar that is used as an intermediate in the synthesis of saccharide derivatives. Nonyl b-D-thioglucopyranoside is also a highly pure, stable chemical that has been modified to meet customer specifications. It can be used for the preparation of glycosyl fluorides, which are used to modify monosaccharides and other carbohydrates.</p>

<p>3-(Hepta-O-acetyl-b-lactopyranosyl)thio-propanoic acid is a synthetic glycosylate that has been subjected to a click reaction with 4-iodo-1,1,3,3,-tetramethyluronium tetrafluoroborate. This glycoside has a purity of &gt;98% and is offered at a price of $6.00/g.</p>

<p>D-myo-inositol-1,3,4,5-tetraphosphate (IP4) is a molecule that is involved in the regulation of cell metabolism and signal transduction. It is synthesized from myo-inositol by the enzyme inositol monophosphatase and hydrolyzed by inositol hexaphosphate kinase to form D-myo-inositol. IP4 can bind to receptors which span the plasma membrane and interact with intracellular Ca2+ channels. This binding results in an increase of cytosolic Ca2+ levels, which may be due to IP4’s ability to activate phosphatidylinositol turnover. IP4 is also involved in the regulation of neuronal death and infectious diseases such as HIV.</p>

<p>Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thiophenyl-D-glycero-a-D-galacto-2--nonulopyranosylonate is a synthetic monosaccharide with a high purity. It is an oligosaccharide consisting of one methylated acetamido group and four acetyl groups on the nonulopyranosyl ring. Methyl 5 Acetamido 4,7,8,9 Tetra O Acetyl 3 Dideoxy 2 Thiophenyl D Glycero A D Galacto 2 Nonulopyranosylonate is used in glycosylation reactions in the synthesis of complex carbohydrates. The compound has been modified by fluorination to increase its stability in harsh conditions.</p>

<p>4-Aminobenzyl b-D-thiogalactopyranoside is a chemical compound that belongs to the group of glycosylation, complex carbohydrate, Methylation, Click modification, Polysaccharide, Fluorination, saccharide, Modification and sugar. It is a synthetic product that can be modified according to customer requests. 4-Aminobenzyl b-D-thiogalactopyranoside is an oligosaccharide that has been custom synthesized for high purity. This product can be used in various applications such as pharmaceuticals and biochemistry research.</p>

<p>4-Methoxyphenyl 4-O-[3,6-di-O-benzyl-2-deoxy-4-O-(4,6-O-benzylidene-2-O-levulinoyl)-bDglucopyranosyl]-2-phthalimido -bDglucopyranoside is a modification of the natural compound 3,6 di O benzyl 2 deoxy 4 O (4,6 O benzylidene 2 O levulinoyl) b D glucopyranosyld. It is a synthetic oligosaccharide that contains one monosaccharide and two polysaccharides. The synthesis of this product involves methylation and glycosylation. This compound has CAS number 5374031 and can be used as an intermediate in the synthesis of other products with fluorination or saccharide modifications.</p>

<p>Mogroside II A2 is a fructan that is found in the fruit of the plant Glycosmis erythrorhiza, which is a member of the family Rutaceae. This compound has been shown to have immune-modulating properties and is used as an ingredient in some pharmaceutical drugs. Mogroside II A2 has also been demonstrated to have antiviral activity and may be helpful for cancer treatment. The effects of this compound on kidney fibrosis are unclear; however, it does have anti-inflammatory properties.</p>

<p>Benzyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-b-D-glucopyranoside is a carbohydrate compound that is used in the synthesis of complex carbohydrates and glycoproteins. This product can be custom synthesized to customer specifications using our unique capabilities. It is a high purity, methylated, glycosylated, and click modified sugar.</p>

<p>(S)-Ketoprofen metabolite.  Soluble in DMSO and methanol</p>

<p>1,2,3,4,6-Penta-O-acetyl-a-D-talopyranose is a fluorinated monosaccharide that belongs to the class of synthetic oligosaccharides. It can be used in glycosylation and polysaccharide synthesis. The chemical structure of this compound has been modified by methylation and click chemistry. 1,2,3,4,6-Penta-O-acetyl-a-D-talopyranose is available in high purity and custom synthesis.</p>