Glycoscience

<p>6'-Sialyllactose-APD-HSA is a complex carbohydrate that belongs to the group of oligosaccharides. It has a CAS number of 102600-80-4 and it is a polysaccharide. This compound is modified with methylation, glycosylation, and click modification. It is also fluorinated and synthesized.</p>

<p>1,3,5-Tri-O-acetyl-2-deoxy-a-D-ribofuranose is a monosaccharide with a modified sugar residue that is obtained by the fluorination of 1,3,5-triacetyl-2,6'-dideoxyglucose. It is a complex carbohydrate that can be used as an additive in food and beverage products. The chemical formula for 1,3,5-triacetyl-2,6'-dideoxyglucose is C10H14O8 and the molecular weight is 392.24 g/mol.</p>

<p>Ulvans are structural polysaccharides present in the cell walls of green algae such as Ulva armoricana, Ulva rotondata, Ulva rigida, Ulva lacterca and Ulva pertusa. They are highly sulphated and contain rhamnose 3-sulphate, xylose, xylose 2-sulphate, glucuronic acid and iduronic acid residues. Ulvan has several potentially valuable functionalities such as gel formation for agricultural and food applications and possible anticoagulant, antioxidant, antihyperlipidemic and antitumoral activities for pharmaceutical applications.<br>The image was kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.</p>

<p>D-Glucose-4-D is a deuterated form of glucose. It is a halophilic sugar that is used in the biosynthesis of lipids. D-Glucose-4-D can be synthesized chemically or by isotope effect by using d-glucose as the starting material. This compound can be used to study lipid synthesis and lipid metabolism in bacteria, such as E. coli, because it has been shown to inhibit the enzyme glycerol dehydratase, which catalyzes the conversion of glycerol to dihydroxyacetone phosphate, an intermediate in lipid biosynthesis. D-Glucose-4-D also inhibits the enzyme phosphatidate phosphohydrolase, which converts phosphatidic acid to diacylglycerol. These compounds are important for membrane lipid formation and are involved in cellular signalling pathways.</p>

<p>Methyl 2-acetamido-4,6-O-benzylidene-2-deoxy-b-D-glucopyranoside is a custom synthesis of an oligosaccharide that can be modified with methylation, glycosylation, or fluorination. It is a complex carbohydrate that has been synthesized using a click modification and high purity. This product is available for purchase as a white to off white powder.</p>

<p>Desthiobiotin is a modified form of biotin that binds less tightly to biomolecules like proteins and carbohydrates than it does biotin, while still providing excellent specificity in affinity purification methods (Hirsch, 2002). The structure of GD2-oligosaccharide-desthiobiotin (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) of its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). The desthiobiotin is attached β to position 1 of the reducing glucose moiety. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentration on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).</p>

<p>Laninamivir is an antiviral drug that inhibits the neuraminidase activity of influenza A and B viruses. It is a prodrug that is activated by esterases to form the active metabolite laninamivir carboxylate, which inhibits virus replication. Laninamivir has been shown to be effective against oseltamivir-resistant mutants and has been used in combination with oseltamivir as a treatment for pandemic influenza. Laninamivir has also been studied in pediatric patients with influenza-like symptoms, with significant reductions in symptom severity, duration of symptoms, and viral load.</p>

<p>Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. A number of publications have suggested that agaroheptaose has properties that include: anti-microbial, antiviral, prebiotic, anti-tumoral, immunomodulatory, anti-inflammatory, glucosidase inhibitory, and hepatoprotective properties.</p>

<p>4-Aminophenyl 2-acetamido-2-deoxy-b-D-glucopyranoside is a monosaccharide that belongs to the group of complex carbohydrates. It is a synthetic compound that has been modified by fluorination and methylation. 4-Aminophenyl 2-acetamido-2-deoxy-b-D-glucopyranoside has been used in the synthesis of polysaccharides and saccharides for various purposes, including as a fluorescence probe for carbohydrate binding proteins. It has also been used as an intermediate in the synthesis of oligosaccharides or polysaccharides.</p>

<p>Neocarrahexadecaose-41,3,5,7,9,11,13,15-octa-O-sulfate sodium salt is a carbohydrate that belongs to the group of modified saccharides. It is synthesized by modifying a sugar with fluorine and methylation. Neocarrahexadecaose-41,3,5,7,9,11,13,15-octa-O-sulfate sodium salt is an oligosaccharide with a high purity and custom synthesis. It is a synthetic compound that has been modified in order to create methylated and glycosylated sugars as well as a click modification. This carbohydrate has not yet been tested for toxicity or side effects in humans.</p>

<p>C-(2,3,4-Tri-O-acetyl-1-hydroxy-b-D-galactopyranosyl)formamide (TRIGAL) is a methylated saccharide that is used to modify polysaccharides. It has been shown to be an effective sugar donor for glycosylation reactions and can be used for the synthesis of complex carbohydrates. TRIGAL is also fluorinated and provides a convenient way to modify oligosaccharides. This product has a high degree of purity and can be custom synthesized with any desired modification.</p>

<p>N-[(e-N-Benzyloxycarbonylamino)caproyl]-b-D-galactopyranosylamine is a synthetic glycosaminoglycan. It is an oligosaccharide, which consists of sugar molecules linked together by glycosidic bonds. This product is custom synthesized and the purity is high. It can be used for various purposes, including research, medicine, and food production.</p>

<p>Butyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside is a custom synthesis that can be used for glycosylation. It has CAS No. 155197-37-8 and it is a fluorination of a monosaccharide with an acetamide group. This product is an oligosaccharide that contains a complex carbohydrate consisting of many sugar residues linked together by glycosidic bonds. The modification of this product includes methylation and sugar substitution.</p>

<p>4'-O-(b-D-Glucopyranosyl)-D-pantothenic acid is a glycosylated, fluorinated, and methylated complex carbohydrate. It has been synthesized by Click chemistry. 4'-O-(b-D-Glucopyranosyl)-D-pantothenic acid has been shown to be a potent inhibitor of the production of proinflammatory cytokines in mouse macrophages. This compound also inhibits the synthesis of bacterial cell wall polysaccharides by inhibiting glycosyltransferases and depolymerizing the sugar backbone.</p>

<p>4-Aminophenyl b-D-thioglucopyranoside is a compound that belongs to the group of small molecules and has been studied for its potential use as a drug to treat brain tumours. It has been shown that 4-Aminophenyl b-D-thioglucopyranoside binds to centromeric DNA sequences in mammalian cells, which can lead to inhibition of transcription and replication. This inhibitory effect on transcription and replication is due to the inhibition of acetyltransferase enzymes by 4-Aminophenyl b-D-thioglucopyranoside.</p>

<p>3-O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-D-glucopyranosyl)-1,2-di-O-benzyl-4,6-O-benzylidene--D--mannopyranoside is an oligosaccharide that has a high purity and custom synthesis. This compound is synthesized by Click modification of the sugar with fluorination. The glycosylation and methylation reactions are then carried out to obtain the final product. 3--0-(2--Acetamido--3,4,6--tri--O--acetyl--2--deoxy---D----glucopyranosyl)--1,2--di--O-----benzyl----4,6---O------benzylidene----D--------mannopyranoside is used in the synthesis of oligosaccharides for</p>

<p>4,6-O-Benzylidene-N-Boc-2-O-p-toluenesulfonyl-1,5-imino-D-glucitol is a monosaccharide that is used in the synthesis of complex carbohydrates. This compound can be custom synthesized and has a high purity. It is also available as a CAS number 1219116-88-7. 4,6-O-Benzylidene can be modified with methylation, click modification, fluorination, saccharide modification, or polysaccharide modification.</p>

<p>Tween 40 is a non-ionic surfactant that has been used in the reaction mechanism of lipolytic enzymes. It has been shown to have metabolic effects on fatty acids, with an increase in the rate at which they are metabolized. Tween 40 is also a component of particle suspensions and may be used as a medium for chemiluminescence reactions. Sodium salts such as sodium benzoate or sodium chloride may be added to the solution to produce light emission. Tween 40 has also been shown to provide linear calibration curves for quantitative measurement of glutamate levels in biological fluids by fluorescence photometry. The use of Tween 40 can prevent eye disorders, such as dry eye syndrome, due to its lubricating properties. Tween 40 is synthesized by the esterification of sorbitol and oleic acid with ethylene oxide.</p>

<p>Ivermectin monosaccharide is a molecule that has been shown to have an inhibitory effect on the uptake of glucose by cyathostomes. This molecule does not bind to inulin, but it does bind to the receptor binding site for ivermectin. Ivermectin monosaccharide has been shown to have a high affinity for the receptor binding site and can be used as an alternative method for detecting low concentrations of ivermectin.</p>

<p>Man-2a N-glycan is a modification of the oligosaccharide mannose that is an important component of many glycoproteins. This product can be custom synthesized, and has been shown to have high purity. It is a carbohydrate that contains a monosaccharide and a polysaccharide. The glycan may also contain methylation, glycosylation, or fluorination. It has CAS No. 491845-49-9, which is the number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society to identify substances.</p>